6pg3 - Revision history

OCA at 07:28, 11 October 2023

2023-10-11T07:28:47Z

← Older revision		Revision as of 07:28, 11 October 2023
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	<StructureSection load='6pg3' size='340' side='right'caption='[[6pg3]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='6pg3' size='340' side='right'caption='[[6pg3]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6pg3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PG3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PG3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6pg3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PG3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHJ:(2-butyl-1H-imidazol-4-yl)methanol'>OHJ</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.04Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pg3 OCA], [~~http~~://pdbe.org/6pg3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pg3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pg3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pg3 ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHJ:(2-butyl-1H-imidazol-4-yl)methanol'>OHJ</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pg3 OCA], [https://pdbe.org/6pg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6pg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pg3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>		[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6pg3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6pg3" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[WD-repeat protein 3D structures\|WD-repeat protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dennis~~, M L~~]]		[[Category: Dennis ML]]
	[[Category: Peat~~, T S]]~~		[[Category: Peat TS]]
	~~[[Category: B-propellor]]~~
	~~[[Category: Chromatin regulator]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Protein binding-inhibitor complex]]~~
	~~[[Category: Scaffolding protein~~]]

OCA at 15:11, 11 December 2019

2019-12-11T15:11:27Z

@@ Line 1: / Line 1: @@
-The entry 6pg3 is ON HOLD  until Paper Publication
+==WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol==
-Authors:
+Fragment screening for a protein-protein interaction inhibitor to WDR5.,Dennis ML, Morrow BJ, Dolezal O, Cuzzupe AN, Stupple AE, Newman J, Bentley J, Hattarki M, Nuttall SD, Foitzik RC, Street IP, Stupple PA, Monahan BJ, Peat TS Struct Dyn. 2019 Nov 14;6(6):064701. doi: 10.1063/1.5122849. eCollection 2019, Nov. PMID:31768400<ref>PMID:31768400</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "6pg3" [edit=sysop:move=sysop]

2019-07-03T04:17:19Z

Protected "6pg3" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:17, 3 July 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6pg3 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-07-03T04:17:17Z

New page: '''Unreleased structure''' The entry 6pg3 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pg3 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]