6q04 - Revision history

OCA at 10:21, 23 October 2024

2024-10-23T10:21:37Z

← Older revision		Revision as of 10:21, 23 October 2024
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	<SX load='6q04' size='340' side='right' viewer='molstar' caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>		<SX load='6q04' size='340' side='right' viewer='molstar' caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human_betacoronavirus_2c_emc~~/2012 Human betacoronavirus 2c ~~emc~~/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [~~http~~://pdbe.org/6q04 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [https://pdbe.org/6q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [https://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 21:

	==See Also==		==See Also==
	*[[Spike protein\|Spike protein]]		*[[Sandbox 3001\|Sandbox 3001]]
			*[[Spike protein 3D structures\|Spike protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Human betacoronavirus 2c ~~emc~~/2012]]		[[Category: Human betacoronavirus 2c EMC/2012]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bosch~~, B J~~]]		[[Category: Bosch BJ]]
	[[Category: DiMaio~~, F D~~]]		[[Category: DiMaio FD]]
	[[Category: Li, W]]		[[Category: Li W]]
	[[Category: Park~~, Y J]]~~		[[Category: Park YJ]]
	~~[[Category: Structural genomic~~]]		[[Category: Sauer M]]
	[[Category: Sauer, M]]		[[Category: Tortorici MA]]
	[[Category: Tortorici~~, M A~~]]		[[Category: Veesler D]]
	[[Category: Veesler, D]]		[[Category: Walls AC]]
	[[Category: Walls~~, A C~~]]		[[Category: Wang Z]]
	[[Category: Wang, Z]]
	~~[[Category: Coronavirus]]~~
	~~[[Category: Membrane fusion]]~~
	~~[[Category: Mers-cov]]~~
	~~[[Category: Spike glycoprotein]]~~
	~~[[Category: Ssgcid]]~~
	~~[[Category: Viral protein~~]]

OCA at 04:45, 11 April 2020

2020-04-11T04:45:57Z

← Older revision		Revision as of 04:45, 11 April 2020
Line 3:		Line 3:
	<SX load='6q04' size='340' side='right' viewer='molstar' caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>		<SX load='6q04' size='340' side='right' viewer='molstar' caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [http://pdbe.org/6q04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [http://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [http://pdbe.org/6q04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [http://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 6q04" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6q04" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:32, 6 March 2020

2020-03-06T23:32:10Z

← Older revision		Revision as of 23:32, 6 March 2020
Line 1:		Line 1:

	==MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid==		==MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid==
	<~~StructureSection~~ load='6q04' size='340' side='right'caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>		<SX load='6q04' size='340' side='right' viewer='molstar' caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
	</~~StructureSection~~>		</SX>
	[[Category: Human betacoronavirus 2c emc/2012]]		[[Category: Human betacoronavirus 2c emc/2012]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 12:35, 18 December 2019

2019-12-18T12:35:56Z

← Older revision		Revision as of 12:35, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6q04' size='340' side='right'caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6q04' size='340' side='right'caption='[[6q04]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [http://pdbe.org/6q04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [http://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [http://pdbe.org/6q04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [http://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to sialosides and dipeptidyl-peptidase 4 (the attachment and entry receptors, respectively). To understand MERS-CoV engagement of sialylated receptors, we determined the cryo-EM structures of S in complex with 5-N-acetyl neuraminic acid, 5-N-glycolyl neuraminic acid, sialyl-Lewis(X), alpha2,3-sialyl-N-acetyl-lactosamine and alpha2,6-sialyl-N-acetyl-lactosamine at 2.7-3.0 A resolution. We show that recognition occurs via a conserved groove that is essential for MERS-CoV S-mediated attachment to sialosides and entry into human airway epithelial cells. Our data illuminate MERS-CoV S sialoside specificity and suggest that selectivity for alpha2,3-linked over alpha2,6-linked receptors results from enhanced interactions with the former class of oligosaccharides. This study provides a structural framework explaining MERS-CoV attachment to sialoside receptors and identifies a site of potential vulnerability to inhibitors of viral entry.

			Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.,Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D Nat Struct Mol Biol. 2019 Dec;26(12):1151-1157. doi: 10.1038/s41594-019-0334-7., Epub 2019 Dec 2. PMID:31792450<ref>PMID:31792450</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6q04" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human betacoronavirus 2c emc/2012]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bosch, B J]]		[[Category: Bosch, B J]]

OCA at 15:13, 11 December 2019

2019-12-11T15:13:06Z

@@ Line 1: / Line 1: @@
-The entry 6q04 is ON HOLD
+==MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid==
+<StructureSection load='6q04' size='340' side='right'caption='[[6q04]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6q04]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q04 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q04 OCA], [http://pdbe.org/6q04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q04 RCSB], [http://www.ebi.ac.uk/pdbsum/6q04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q04 ProSAT]</span></td></tr>

OCA: Protected "6q04" [edit=sysop:move=sysop]

2019-08-07T04:24:31Z

Protected "6q04" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:24, 7 August 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6q04 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-08-07T04:24:29Z

New page: '''Unreleased structure''' The entry 6q04 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6q04 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]