6rix - Revision history

OCA at 12:21, 24 January 2024

2024-01-24T12:21:20Z

← Older revision		Revision as of 12:21, 24 January 2024
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	<StructureSection load='6rix' size='340' side='right'caption='[[6rix]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='6rix' size='340' side='right'caption='[[6rix]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rix]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ccug_50989 Ccug 50989~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RIX FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_intracellulare_subsp._chimaera Mycobacterium intracellulare subsp. chimaera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RIX FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.655Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CSX~~:~~S-OXY~~+~~CYSTEINE~~'>~~CSX~~</scene>~~</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BWK49_00400~~, ~~MYCOZU1_00080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=222805 CCUG 50989])~~<~~/td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rix OCA], [https://pdbe.org/6rix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rix RCSB], [https://www.ebi.ac.uk/pdbsum/6rix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rix ProSAT]</span></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rix OCA], [~~http~~://pdbe.org/6rix PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rix RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rix PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rix ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	[[http://www.uniprot.org/uniprot/A0A220Y4A5_9MYCO A0A220Y4A5_9MYCO]] Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.[ARBA:ARBA00002835][RuleBase:RU362085]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Ccug 50989]]~~
	~~[[Category: DNA helicase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Beyer~~, H M~~]]		[[Category: Mycobacterium intracellulare subsp. chimaera]]
	[[Category: Iwai, H]]		[[Category: Beyer HM]]
	[[Category: Lountos~~, G T~~]]		[[Category: Iwai H]]
	[[Category: Mikula~~, M K~~]]		[[Category: Lountos GT]]
	[[Category: Wlodawer, A]]		[[Category: Mikula MK]]
	~~[[Category: Hydrolase]]~~		[[Category: Wlodawer A]]
	~~[[Category: Intein]]~~
	~~[[Category: Protein-splicing]]~~
	~~[[Category: Splicing~~]]

OCA at 10:51, 24 December 2020

2020-12-24T10:51:03Z

← Older revision		Revision as of 10:51, 24 December 2020
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	==Crystal structure of MchDnaB-1 intein==		==Crystal structure of MchDnaB-1 intein==
	<StructureSection load='6rix' size='340' side='right'caption='[[6rix]]' scene=''>		<StructureSection load='6rix' size='340' side='right'caption='[[6rix]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RIX FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rix]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ccug_50989 Ccug 50989]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RIX FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rix OCA], [http://pdbe.org/6rix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rix RCSB], [http://www.ebi.ac.uk/pdbsum/6rix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rix ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BWK49_00400, MYCOZU1_00080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=222805 CCUG 50989])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rix OCA], [http://pdbe.org/6rix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rix RCSB], [http://www.ebi.ac.uk/pdbsum/6rix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rix ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/A0A220Y4A5_9MYCO A0A220Y4A5_9MYCO]] Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.[ARBA:ARBA00002835][RuleBase:RU362085]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes based on their characteristic sequences. We investigated the structural basis of the protein splicing mechanism of class 3 inteins by determining crystal structures of variants of a class 3 intein from Mycobacterium chimaera and molecular dynamics simulations, which suggested that the class 3 intein utilizes a different splicing mechanism from that of class 1 and 2 inteins. The class 3 intein uses a bond cleavage strategy reminiscent of proteases but share the same Hedgehog/INTein (HINT) fold of other intein classes. Engineering of class 3 inteins from a class 1 intein indicated that a class 3 intein would unlikely evolve directly from a class 1 or 2 intein. The HINT fold appears as structural and functional solution for trans-peptidyl and trans-esterification reactions commonly exploited by diverse mechanisms using different combinations of amino-acid types for the active-site residues.

			The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms.,Beyer HM, Virtanen SI, Aranko AS, Mikula KM, Lountos GT, Wlodawer A, Ollila OHS, Iwai H Int J Mol Sci. 2020 Nov 7;21(21). pii: ijms21218367. doi: 10.3390/ijms21218367. PMID:33171880<ref>PMID:33171880</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6rix" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Helicase 3D structures\|Helicase 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Ccug 50989]]
			[[Category: DNA helicase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Beyer HM]]		[[Category: Beyer, H M]]
	[[Category: Iwai H]]		[[Category: Iwai, H]]
	[[Category: Lountos GT]]		[[Category: Lountos, G T]]
	[[Category: Mikula MK]]		[[Category: Mikula, M K]]
	[[Category: Wlodawer A]]		[[Category: Wlodawer, A]]
			[[Category: Hydrolase]]
			[[Category: Intein]]
			[[Category: Protein-splicing]]
			[[Category: Splicing]]

OCA at 05:29, 13 May 2020

2020-05-13T05:29:27Z

← Older revision		Revision as of 05:29, 13 May 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6rix is ~~ON HOLD~~		==Crystal structure of MchDnaB-1 intein==
			<StructureSection load='6rix' size='340' side='right'caption='[[6rix]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RIX FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rix OCA], [http://pdbe.org/6rix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rix RCSB], [http://www.ebi.ac.uk/pdbsum/6rix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rix ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Beyer HM]]
			[[Category: Iwai H]]
			[[Category: Lountos GT]]
			[[Category: Mikula MK]]
			[[Category: Wlodawer A]]

OCA at 09:13, 17 July 2019

2019-07-17T09:13:04Z

← Older revision		Revision as of 09:13, 17 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6rix is ON HOLD ~~until Paper Publication~~		The entry 6rix is ON HOLD

	Authors:		Authors:

OCA: Protected "6rix" [edit=sysop:move=sysop]

2019-05-01T07:26:37Z

Protected "6rix" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:26, 1 May 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6rix is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-05-01T07:26:36Z

New page: '''Unreleased structure''' The entry 6rix is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rix is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]