6rmy - Revision history

OCA at 12:24, 24 January 2024

2024-01-24T12:24:07Z

← Older revision		Revision as of 12:24, 24 January 2024
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	==Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide==		==Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide==
	<StructureSection load='6rmy' size='340' side='right'caption='[[6rmy]]' scene=''>		<StructureSection load='6rmy' size='340' side='right'caption='[[6rmy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RMY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [https://pdbe.org/6rmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [https://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=V14:3-(CYCLOOCTYLAMINO)-2,5,6-TRIFLUORO-4-[(2-HYDROXYETHYL)SULFONYL]BENZENESULFONAMIDE'>V14</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [https://pdbe.org/6rmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [https://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>

	==See Also==		==See Also==
	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]		*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Smirnov, A~~, Paketuryte, V, Manakova, E, Grazulis, S~~]]		[[Category: Grazulis S]]
			[[Category: Manakova E]]
			[[Category: Paketuryte V]]
			[[Category: Smirnov A]]

OCA at 15:17, 8 June 2021

2021-06-08T15:17:52Z

← Older revision		Revision as of 15:17, 8 June 2021
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	<StructureSection load='6rmy' size='340' side='right'caption='[[6rmy]]' scene=''>		<StructureSection load='6rmy' size='340' side='right'caption='[[6rmy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RMY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RMY FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RMY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [~~http~~://pdbe.org/6rmy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [https://pdbe.org/6rmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [https://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:55, 20 July 2020

2020-07-20T08:55:06Z

← Older revision		Revision as of 08:55, 20 July 2020
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [http://pdbe.org/6rmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [http://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [http://pdbe.org/6rmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [http://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>
	</table>		</table>

			==See Also==
			*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Smirnov, A, Paketuryte, V, Manakova, E, Grazulis, S]]		[[Category: Smirnov, A, Paketuryte, V, Manakova, E, Grazulis, S]]

OCA at 06:27, 3 June 2020

2020-06-03T06:27:34Z

← Older revision		Revision as of 06:27, 3 June 2020
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	~~'''Unreleased structure'''~~

	~~The entry 6rmy is ON HOLD~~		==Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide==
			<StructureSection load='6rmy' size='340' side='right'caption='[[6rmy]]' scene=''>
	~~Authors: Smirnov, A., Paketuryte, V., Manakova, E., Grazulis, S.~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RMY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RMY FirstGlance]. <br>
	~~Description:~~ Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rmy OCA], [http://pdbe.org/6rmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rmy RCSB], [http://www.ebi.ac.uk/pdbsum/6rmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rmy ProSAT]</span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		</table>
	[[~~Category~~: ~~Manakova~~, E]]		__TOC__
	[[~~Category~~: ~~Grazulis, S]~~]		</StructureSection>
	[[Category: ~~Paketuryte, V~~]]		[[Category: Large Structures]]
	[[Category: Smirnov, A]]		[[Category: Smirnov, A, Paketuryte, V, Manakova, E, Grazulis, S]]

OCA: Protected "6rmy" [edit=sysop:move=sysop]

2019-05-21T06:00:42Z

Protected "6rmy" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:00, 21 May 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6rmy is ON HOLD Authors: Smirnov, A., Paketuryte, V., Manakova, E., Grazulis, S. Description: Human Carbonic anhydrase II mutant T199V bound by 3-(...

2019-05-21T06:00:40Z

New page: '''Unreleased structure''' The entry 6rmy is ON HOLD Authors: Smirnov, A., Paketuryte, V., Manakova, E., Grazulis, S. Description: Human Carbonic anhydrase II mutant T199V bound by 3-(...

New page

'''Unreleased structure'''

The entry 6rmy is ON HOLD

Authors: Smirnov, A., Paketuryte, V., Manakova, E., Grazulis, S.

Description: Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
[[Category: Unreleased Structures]]
[[Category: Manakova, E]]
[[Category: Grazulis, S]]
[[Category: Paketuryte, V]]
[[Category: Smirnov, A]]