6rob - Revision history

OCA at 18:32, 8 September 2026

2026-09-08T18:32:16Z

← Older revision		Revision as of 18:32, 8 September 2026
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	<StructureSection load='6rob' size='340' side='right'caption='[[6rob]], [[Resolution\|resolution]] 0.93Å' scene=''>		<StructureSection load='6rob' size='340' side='right'caption='[[6rob]], [[Resolution\|resolution]] 0.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[6rob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROB FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROB FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.929Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.929Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE7:(4-CARBOXYPHENYL)(CHLORO)MERCURY'>BE7</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=KBZ:4-cyanobenzenesulfonamide'>KBZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE7:(4-CARBOXYPHENYL)(CHLORO)MERCURY'>BE7</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=KBZ:4-cyanobenzenesulfonamide'>KBZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rob OCA], [https://pdbe.org/6rob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rob RCSB], [https://www.ebi.ac.uk/pdbsum/6rob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rob ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rob OCA], [https://pdbe.org/6rob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rob RCSB], [https://www.ebi.ac.uk/pdbsum/6rob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rob ProSAT]</span></td></tr>
	</table>		</table>
	~~== Disease ==~~
	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	~~== Function ==~~
	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Homo sapiens]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gloeckner S]]		[[Category: Gloeckner S]]
	[[Category: Heine A]]		[[Category: Heine A]]
	[[Category: Klebe G]]		[[Category: Klebe G]]

OCA at 12:25, 24 January 2024

2024-01-24T12:25:02Z

← Older revision		Revision as of 12:25, 24 January 2024
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	==Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide==		==Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide==
	<StructureSection load='6rob' size='340' side='right'caption='[[6rob]]' scene=''>		<StructureSection load='6rob' size='340' side='right'caption='[[6rob]], [[Resolution\|resolution]] 0.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ROB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rob OCA], [~~http~~://pdbe.org/6rob PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rob RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rob PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rob ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.929Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE7:(4-CARBOXYPHENYL)(CHLORO)MERCURY'>BE7</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=KBZ:4-cyanobenzenesulfonamide'>KBZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rob OCA], [https://pdbe.org/6rob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rob RCSB], [https://www.ebi.ac.uk/pdbsum/6rob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rob ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The fluorination of lead-like compounds is a common tool in medicinal chemistry to alter molecular properties in various ways and with different goals. We herein present a detailed study of the binding of fluorinated benzenesulfonamides to human Carbonic Anhydrase II by complementing macromolecular X-ray crystallographic observations with thermodynamic and kinetic data collected with the novel method of kinITC. Our findings comprise so far unknown alternative binding modes in the crystalline state for some of the investigated compounds as well as complex thermodynamic and kinetic structure-activity relationships. They suggest that fluorination of the benzenesulfonamide core is especially advantageous in one position with respect to the kinetic signatures of binding and that a higher degree of fluorination does not necessarily provide for a higher affinity or more favorable kinetic binding profiles. Lastly, we propose a relationship between the kinetics of binding and ligand acidity based on a small set of compounds with similar substitution patterns.

			The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II.,Glockner S, Ngo K, Wagner B, Heine A, Klebe G Biomolecules. 2020 Mar 27;10(4). pii: biom10040509. doi: 10.3390/biom10040509. PMID:32230853<ref>PMID:32230853</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6rob" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gloeckner S]]		[[Category: Gloeckner S]]
	[[Category: Heine A]]		[[Category: Heine A]]
	[[Category: Klebe G]]		[[Category: Klebe G]]

OCA at 06:57, 15 April 2020

2020-04-15T06:57:26Z

← Older revision		Revision as of 06:57, 15 April 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6rob is ~~ON HOLD until Paper Publication~~		==Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide==
			<StructureSection load='6rob' size='340' side='right'caption='[[6rob]]' scene=''>
	~~Authors~~: ~~Gloeckner~~, S., ~~Heine~~, A., ~~Klebe~~, G.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ROB FirstGlance]. <br>
	~~Description: Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rob OCA], [http://pdbe.org/6rob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rob RCSB], [http://www.ebi.ac.uk/pdbsum/6rob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rob ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Gloeckner, S]]		__TOC__
	[[Category: Heine, A]]		</StructureSection>
	[[Category: Klebe, G]]		[[Category: Large Structures]]
			[[Category: Gloeckner S]]
			[[Category: Heine A]]
			[[Category: Klebe G]]

OCA: Protected "6rob" [edit=sysop:move=sysop]

2019-05-22T04:15:45Z

Protected "6rob" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:15, 22 May 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6rob is ON HOLD until Paper Publication Authors: Gloeckner, S., Heine, A., Klebe, G. Description: Human Carbonic Anhydrase II in complex with 4-cya...

2019-05-22T04:15:44Z

New page: '''Unreleased structure''' The entry 6rob is ON HOLD until Paper Publication Authors: Gloeckner, S., Heine, A., Klebe, G. Description: Human Carbonic Anhydrase II in complex with 4-cya...

New page

'''Unreleased structure'''

The entry 6rob is ON HOLD until Paper Publication

Authors: Gloeckner, S., Heine, A., Klebe, G.

Description: Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide
[[Category: Unreleased Structures]]
[[Category: Gloeckner, S]]
[[Category: Heine, A]]
[[Category: Klebe, G]]