6rss - Revision history

OCA at 06:07, 19 June 2024

2024-06-19T06:07:49Z

← Older revision		Revision as of 06:07, 19 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rss]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rss]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RSS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rss OCA], [https://pdbe.org/6rss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rss RCSB], [https://www.ebi.ac.uk/pdbsum/6rss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rss ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rss OCA], [https://pdbe.org/6rss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rss RCSB], [https://www.ebi.ac.uk/pdbsum/6rss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rss ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:01, 14 June 2023

2023-06-14T11:01:48Z

← Older revision		Revision as of 11:01, 14 June 2023
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	==Solution structure of the fourth WW domain of WWP2 with GB1-tag==		==Solution structure of the fourth WW domain of WWP2 with GB1-tag==
	<StructureSection load='6rss' size='340' side='right'caption='[[6rss~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='6rss' size='340' side='right'caption='[[6rss]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rss]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rss]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RSS FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.26 2.3.2.26] </span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rss OCA], [https://pdbe.org/6rss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rss RCSB], [https://www.ebi.ac.uk/pdbsum/6rss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rss ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rss OCA], [~~http~~://pdbe.org/6rss PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rss RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rss PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rss ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/WWP2_HUMAN WWP2_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.<ref>PMID:19274063</ref> <ref>PMID:19651900</ref>		[https://www.uniprot.org/uniprot/WWP2_HUMAN WWP2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.<ref>PMID:19274063</ref> <ref>PMID:19651900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6rss" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rss" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Transferase]]~~		[[Category: Blumenschein TMA]]
	[[Category: Blumenschein~~, T M.A~~]]		[[Category: Chantry A]]
	[[Category: Chantry, A]]		[[Category: Tolchard J]]
	[[Category: Tolchard, J]]		[[Category: Wahl LC]]
	[[Category: Wahl~~, L C~~]]		[[Category: Watt JE]]
	[[Category: Watt~~, J E]]~~
	~~[[Category: E3 ubiquitin ligase]]~~
	~~[[Category: Nedd4]]~~
	~~[[Category: Ppxy motif binding]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Three-stranded antiparallel beta-sheet~~]]

OCA at 05:25, 10 October 2019

2019-10-10T05:25:34Z

@@ Line 1: / Line 1: @@
-The entry 6rss is ON HOLD  until Paper Publication
+==Solution structure of the fourth WW domain of WWP2 with GB1-tag==
-Authors:
+Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms.,Wahl LC, Watt JE, Yim HTT, De Bourcier D, Tolchard J, Soond SM, Blumenschein TMA, Chantry A Int J Mol Sci. 2019 Sep 21;20(19). pii: ijms20194682. doi: 10.3390/ijms20194682. PMID:31546607<ref>PMID:31546607</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 21:17, 5 June 2019

2019-06-05T21:17:47Z

← Older revision		Revision as of 21:17, 5 June 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6rss is ON HOLD		The entry 6rss is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6rss" [edit=sysop:move=sysop]

2019-05-29T04:47:12Z

Protected "6rss" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:47, 29 May 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6rss is ON HOLD Authors: Description: Category: Unreleased Structures

2019-05-29T04:47:11Z

New page: '''Unreleased structure''' The entry 6rss is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rss is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]