6rt2 - Revision history

OCA at 12:27, 24 January 2024

2024-01-24T12:27:46Z

← Older revision		Revision as of 12:27, 24 January 2024
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	<StructureSection load='6rt2' size='340' side='right'caption='[[6rt2]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='6rt2' size='340' side='right'caption='[[6rt2]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rt2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rt2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CV5:(3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic+acid'>CV5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5oml\|5oml]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CV5:(3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic+acid'>CV5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt2 OCA], [https://pdbe.org/6rt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rt2 RCSB], [https://www.ebi.ac.uk/pdbsum/6rt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt2 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt2 OCA], [~~http~~://pdbe.org/6rt2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rt2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rt2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8IEW2_TRYBB Q8IEW2_TRYBB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Trybb~~]]		[[Category: Trypanosoma brucei brucei]]
	[[Category: Dawidowski, M]]		[[Category: Dawidowski M]]
	[[Category: Dubin, G]]		[[Category: Dubin G]]
	[[Category: Fino, R]]		[[Category: Fino R]]
	[[Category: Napolitano, V]]		[[Category: Napolitano V]]
	[[Category: Popowicz, G]]		[[Category: Popowicz G]]
	[[Category: Ratkova~~, E L~~]]		[[Category: Ratkova EL]]
	[[Category: Sattler, M]]		[[Category: Sattler M]]
	[[Category: Tetko~~, I V]]~~		[[Category: Tetko IV]]
	~~[[Category: Peroxisomal translocation]]~~
	~~[[Category: Ppi inhibition]]~~
	~~[[Category: Protein-inhibitor complex]]~~
	~~[[Category: Signaling protein~~]]

OCA at 07:04, 29 April 2020

2020-04-29T07:04:23Z

← Older revision		Revision as of 07:04, 29 April 2020
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	<StructureSection load='6rt2' size='340' side='right'caption='[[6rt2]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='6rt2' size='340' side='right'caption='[[6rt2]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rt2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rt2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CV5:(3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic+acid'>CV5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CV5:(3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic+acid'>CV5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5oml\|5oml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5oml\|5oml]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt2 OCA], [http://pdbe.org/6rt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rt2 RCSB], [http://www.ebi.ac.uk/pdbsum/6rt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt2 OCA], [http://pdbe.org/6rt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rt2 RCSB], [http://www.ebi.ac.uk/pdbsum/6rt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt2 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
			[[Category: Trybb]]
	[[Category: Dawidowski, M]]		[[Category: Dawidowski, M]]
	[[Category: Dubin, G]]		[[Category: Dubin, G]]

OCA at 06:52, 8 April 2020

2020-04-08T06:52:56Z

@@ Line 1: / Line 1: @@
-The entry 6rt2 is ON HOLD
+==Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules designed to investigate the water envelope==
-Authors: Napolitano, V., Ratkova, E.L., Dawidowski, M., Dubin, G., Fino, R., Popowicz, G., Sattler, M., Tetko, I.V.
+Water envelope has a critical impact on the design of protein-protein interaction inhibitors.,Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV Chem Commun (Camb). 2020 Mar 20. doi: 10.1039/c9cc07714f. PMID:32195483<ref>PMID:32195483</ref>
-Description: Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules designed to investigate the water envelope
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Dawidowski, M]]
 [[Category: Dubin, G]]
 [[Category: Fino, R]]
 [[Category: Sattler, M]]
-[[Category: Popowicz, G]]
+[[Category: Tetko, I V]]

OCA: Protected "6rt2" [edit=sysop:move=sysop]

2019-05-29T04:47:59Z

Protected "6rt2" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:47, 29 May 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6rt2 is ON HOLD Authors: Napolitano, V., Ratkova, E.L., Dawidowski, M., Dubin, G., Fino, R., Popowicz, G., Sattler, M., Tetko, I.V. Description: Cr...

2019-05-29T04:47:57Z

New page: '''Unreleased structure''' The entry 6rt2 is ON HOLD Authors: Napolitano, V., Ratkova, E.L., Dawidowski, M., Dubin, G., Fino, R., Popowicz, G., Sattler, M., Tetko, I.V. Description: Cr...

New page

'''Unreleased structure'''

The entry 6rt2 is ON HOLD

Authors: Napolitano, V., Ratkova, E.L., Dawidowski, M., Dubin, G., Fino, R., Popowicz, G., Sattler, M., Tetko, I.V.

Description: Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules designed to investigate the water envelope
[[Category: Unreleased Structures]]
[[Category: Dawidowski, M]]
[[Category: Ratkova, E.L]]
[[Category: Napolitano, V]]
[[Category: Tetko, I.V]]
[[Category: Dubin, G]]
[[Category: Fino, R]]
[[Category: Sattler, M]]
[[Category: Popowicz, G]]