6rtb - Revision history

OCA at 10:12, 22 May 2024

2024-05-22T10:12:59Z

← Older revision		Revision as of 10:12, 22 May 2024
Line 3:		Line 3:
	<SX load='6rtb' size='340' side='right' viewer='molstar' caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>		<SX load='6rtb' size='340' side='right' viewer='molstar' caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RTB FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6rt0\|6rt0]]</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.46Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SNCA, NACP, PARK1 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [https://pdbe.org/6rtb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [https://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [~~http~~://pdbe.org/6rtb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN]] Note=Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer disease amyloid plaque, and a major component of Lewy body inclusions. They are also found within Lewy body (LB)-like intraneuronal inclusions, glial inclusions and axonal spheroids in neurodegeneration with brain iron accumulation type 1. Defects in SNCA are the cause of Parkinson disease type 1 (PARK1) [MIM:[~~http~~://omim.org/entry/168601 168601]]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.<ref>PMID:9197268</ref> <ref>PMID:9462735</ref> <ref>PMID:14755719</ref> Defects in SNCA are the cause of Parkinson disease type 4 (PARK4) [MIM:[~~http~~://omim.org/entry/605543 605543]]. A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Defects in SNCA are the cause of dementia Lewy body (DLB) [MIM:[~~http~~://omim.org/entry/127750 127750]]. A neurodegenerative disorder clinically characterized by mental impairment leading to dementia, parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Brainstem or cortical intraneuronal accumulations of aggregated proteins (Lewy bodies) are the only essential pathologic features. Patients may also have hippocampal and neocortical senile plaques, sometimes in sufficient number to fulfill the diagnostic criteria for Alzheimer disease.		[https://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN] Note=Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer disease amyloid plaque, and a major component of Lewy body inclusions. They are also found within Lewy body (LB)-like intraneuronal inclusions, glial inclusions and axonal spheroids in neurodegeneration with brain iron accumulation type 1. Defects in SNCA are the cause of Parkinson disease type 1 (PARK1) [MIM:[https://omim.org/entry/168601 168601]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.<ref>PMID:9197268</ref> <ref>PMID:9462735</ref> <ref>PMID:14755719</ref> Defects in SNCA are the cause of Parkinson disease type 4 (PARK4) [MIM:[https://omim.org/entry/605543 605543]. A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Defects in SNCA are the cause of dementia Lewy body (DLB) [MIM:[https://omim.org/entry/127750 127750]. A neurodegenerative disorder clinically characterized by mental impairment leading to dementia, parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Brainstem or cortical intraneuronal accumulations of aggregated proteins (Lewy bodies) are the only essential pathologic features. Patients may also have hippocampal and neocortical senile plaques, sometimes in sufficient number to fulfill the diagnostic criteria for Alzheimer disease.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN]] May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.		[https://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN] May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arteni~~, A A~~]]		[[Category: Arteni AA]]
	[[Category: Bockmann, A]]		[[Category: Bockmann A]]
	[[Category: Bousset, L]]		[[Category: Bousset L]]
	[[Category: Guerrero-Ferreira, R]]		[[Category: Guerrero-Ferreira R]]
	[[Category: Meier~~, B H~~]]		[[Category: Meier BH]]
	[[Category: Melki, R]]		[[Category: Melki R]]
	[[Category: Stahlberg, H]]		[[Category: Stahlberg H]]
	[[Category: Taylor~~, N M.I]]~~		[[Category: Taylor NMI]]
	~~[[Category: Amyloid]]~~
	~~[[Category: Parkinson]]~~
	~~[[Category: Protein fibril~~]]

OCA at 05:49, 11 April 2020

2020-04-11T05:49:54Z

← Older revision		Revision as of 05:49, 11 April 2020
Line 3:		Line 3:
	<SX load='6rtb' size='340' side='right' viewer='molstar' caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>		<SX load='6rtb' size='340' side='right' viewer='molstar' caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RTB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rt0\|6rt0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rt0\|6rt0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNCA, NACP, PARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNCA, NACP, PARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [http://pdbe.org/6rtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [http://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [http://pdbe.org/6rtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [http://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 6rtb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rtb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Alpha-synuclein\|Alpha-synuclein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:24, 7 March 2020

2020-03-07T00:24:16Z

← Older revision		Revision as of 00:24, 7 March 2020
Line 1:		Line 1:

	==cryo-em structure of alpha-synuclein fibril polymorph 2B==		==cryo-em structure of alpha-synuclein fibril polymorph 2B==
	<~~StructureSection~~ load='6rtb' size='340' side='right'caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>		<SX load='6rtb' size='340' side='right' viewer='molstar' caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTB FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
	</~~StructureSection~~>		</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 13:07, 18 December 2019

2019-12-18T13:07:45Z

← Older revision		Revision as of 13:07, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6rtb' size='340' side='right'caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>		<StructureSection load='6rtb' size='340' side='right'caption='[[6rtb]], [[Resolution\|resolution]] 3.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rt0\|6rt0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6rt0\|6rt0]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNCA, NACP, PARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [http://pdbe.org/6rtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [http://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [http://pdbe.org/6rtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [http://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN]] May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.		[[http://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN]] May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha-synuclein fibrils (residues 1-121), composed of two protofibrils that are connected via a densely-packed interface formed by residues 50-57 (Guerrero-Ferreira, eLife 218;7:e36402). We here report two new polymorphic atomic structures of alpha-synuclein fibrils termed polymorphs 2a and 2b, at 3.0 A and 3.4 A resolution, respectively. These polymorphs show a radically different structure compared to previously reported polymorphs. The new structures have a 10 nm fibril diameter and are composed of two protofilaments which interact via intermolecular salt-bridges between amino acids K45, E57 (polymorph 2a) or E46 (polymorph 2b). The non-amyloid component (NAC) region of alpha-synuclein is fully buried by previously non-described interactions with the N-terminus. A hydrophobic cleft, the location of familial PD mutation sites, and the nature of the protofilament interface now invite to formulate hypotheses about fibril formation, growth and stability.

			Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.,Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Bockmann A, Bousset L, Stahlberg H Elife. 2019 Dec 9;8. pii: 48907. doi: 10.7554/eLife.48907. PMID:31815671<ref>PMID:31815671</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6rtb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arteni, A A]]		[[Category: Arteni, A A]]

OCA at 07:11, 26 June 2019

2019-06-26T07:11:08Z

@@ Line 1: / Line 1: @@
-The entry 6rtb is ON HOLD
+==cryo-em structure of alpha-synuclein fibril polymorph 2B==
+<StructureSection load='6rtb' size='340' side='right'caption='[[6rtb]], [[Resolution|resolution]] 3.46&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rtb]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTB FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rt0|6rt0]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtb OCA], [http://pdbe.org/6rtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtb RCSB], [http://www.ebi.ac.uk/pdbsum/6rtb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtb ProSAT]</span></td></tr>

OCA: Protected "6rtb" [edit=sysop:move=sysop]

2019-05-29T04:48:52Z

Protected "6rtb" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:48, 29 May 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6rtb is ON HOLD Authors: Description: Category: Unreleased Structures

2019-05-29T04:48:50Z

New page: '''Unreleased structure''' The entry 6rtb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rtb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]