6sci - Revision history

OCA at 12:39, 24 January 2024

2024-01-24T12:39:31Z

← Older revision		Revision as of 12:39, 24 January 2024
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	<StructureSection load='6sci' size='340' side='right'caption='[[6sci]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6sci' size='340' side='right'caption='[[6sci]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SCI FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SCI FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[6scg\|6scg]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~adhE, ana, b1241, JW1228 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sci OCA], [https://pdbe.org/6sci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sci RCSB], [https://www.ebi.ac.uk/pdbsum/6sci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sci ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sci OCA], [https://pdbe.org/6sci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sci RCSB], [https://www.ebi.ac.uk/pdbsum/6sci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sci ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ADHE_ECOLI ADHE_ECOLI]] This enzyme has three activities: ADH, ACDH, and PFL-deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction.		[https://www.uniprot.org/uniprot/ADHE_ECOLI ADHE_ECOLI] This enzyme has three activities: ADH, ACDH, and PFL-deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecoli~~]]		[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bragginton, E]]		[[Category: Bragginton E]]
	[[Category: Lovering~~, A L]]~~		[[Category: Lovering AL]]
	~~[[Category: Aldehyde alcohol dehydrogenase]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 06:52, 17 March 2021

2021-03-17T06:52:18Z

← Older revision		Revision as of 06:52, 17 March 2021
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	==Structure of AdhE form 1==		==Structure of AdhE form 1==
	<StructureSection load='6sci' size='340' side='right'caption='[[6sci]]' scene=''>		<StructureSection load='6sci' size='340' side='right'caption='[[6sci]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SCI FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SCI FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sci OCA], [~~http~~://pdbe.org/6sci PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sci RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sci PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sci ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6scg\|6scg]]</div></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">adhE, ana, b1241, JW1228 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sci OCA], [https://pdbe.org/6sci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sci RCSB], [https://www.ebi.ac.uk/pdbsum/6sci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sci ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/ADHE_ECOLI ADHE_ECOLI]] This enzyme has three activities: ADH, ACDH, and PFL-deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The bifunctional alcohol/aldehyde dehydrogenase (AdhE) comprises both an N-terminal aldehyde dehydrogenase (AldDH) and a C-terminal alcohol dehydrogenase (ADH). In vivo, full-length AdhE oligomerizes into long oligomers known as spirosomes. However, structural analysis of AdhE is challenging owing to the heterogeneity of the spirosomes. Therefore, the domains of AdhE are best characterized separately. Here, the structure of ADH from the pathogenic Escherichia coli O157:H7 was determined to 1.65 A resolution. The dimeric crystal structure was confirmed in solution by small-angle X-ray scattering.

			High-resolution structure of the alcohol dehydrogenase domain of the bifunctional bacterial enzyme AdhE.,Azmi L, Bragginton EC, Cadby IT, Byron O, Roe AJ, Lovering AL, Gabrielsen M Acta Crystallogr F Struct Biol Commun. 2020 Sep 1;76(Pt 9):414-421. doi:, 10.1107/S2053230X20010237. Epub 2020 Aug 19. PMID:32880589<ref>PMID:32880589</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6sci" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Ecoli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bragginton E]]		[[Category: Bragginton, E]]
	[[Category: Lovering AL]]		[[Category: Lovering, A L]]
			[[Category: Aldehyde alcohol dehydrogenase]]
			[[Category: Oxidoreductase]]

OCA at 11:13, 26 August 2020

2020-08-26T11:13:05Z

← Older revision		Revision as of 11:13, 26 August 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6sci is ~~ON HOLD until Paper Publication~~		==Structure of AdhE form 1==
			<StructureSection load='6sci' size='340' side='right'caption='[[6sci]]' scene=''>
	~~Authors~~: ~~Lovering~~, A.L., ~~Bragginton~~, E.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SCI FirstGlance]. <br>
	~~Description: Structure of AdhE form 1~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sci OCA], [http://pdbe.org/6sci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sci RCSB], [http://www.ebi.ac.uk/pdbsum/6sci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sci ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Bragginton, E]]		__TOC__
	[[Category: Lovering~~, A.L~~]]		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Bragginton E]]
			[[Category: Lovering AL]]

OCA at 09:18, 29 July 2020

2020-07-29T09:18:07Z

← Older revision		Revision as of 09:18, 29 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6sci is ON HOLD		The entry 6sci is ON HOLD until Paper Publication

	Authors: Lovering, A.L., Bragginton, E.		Authors: Lovering, A.L., Bragginton, E.

OCA: Protected "6sci" [edit=sysop:move=sysop]

2019-07-31T04:57:52Z

Protected "6sci" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:57, 31 July 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6sci is ON HOLD Authors: Lovering, A.L., Bragginton, E. Description: Structure of AdhE form 1 Category: Unreleased Structures [[Category: Bragg...

2019-07-31T04:57:50Z

New page: '''Unreleased structure''' The entry 6sci is ON HOLD Authors: Lovering, A.L., Bragginton, E. Description: Structure of AdhE form 1 Category: Unreleased Structures [[Category: Bragg...

New page

'''Unreleased structure'''

The entry 6sci is ON HOLD

Authors: Lovering, A.L., Bragginton, E.

Description: Structure of AdhE form 1
[[Category: Unreleased Structures]]
[[Category: Bragginton, E]]
[[Category: Lovering, A.L]]