6sql - Revision history

OCA at 12:45, 24 January 2024

2024-01-24T12:45:58Z

← Older revision		Revision as of 12:45, 24 January 2024
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	<StructureSection load='6sql' size='340' side='right'caption='[[6sql]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='6sql' size='340' side='right'caption='[[6sql]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sql]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SQL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SQL FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LTK:~{N}~~-[~~3-(aminomethyl)phenyl~~]~~-5-chloranyl-3-methyl-1-benzothiophene-~~2~~-sulfonamide'>LTK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>inhA, Rv1484, MTCY277.05 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=83332 MYCTU])</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LTK:~{N}-[3-(aminomethyl)phenyl]-5-chloranyl-3-methyl-1-benzothiophene-2-sulfonamide'>LTK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Enoyl~~-[~~acyl~~-~~carrier-protein]_reductase_~~(~~NADH~~) ~~Enoyl~~-~~[acyl~~-~~carrier~~-~~protein] reductase (NADH)]~~, ~~with EC number [http~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sql OCA], [https://pdbe.org/6sql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sql RCSB], [https://www.ebi.ac.uk/pdbsum/6sql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sql ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sql OCA], [~~http~~://pdbe.org/6sql PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sql RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sql PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sql ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6sql" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6sql" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Myctu~~]]		[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Abell, C]]		[[Category: Abell C]]
	[[Category: Blundell~~, T L~~]]		[[Category: Blundell TL]]
	[[Category: Coyne~~, A G~~]]		[[Category: Coyne AG]]
	[[Category: Mendes, V]]		[[Category: Mendes V]]
	[[Category: Sabbah, M]]		[[Category: Sabbah M]]
	~~[[Category: Inha]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 07:05, 29 April 2020

2020-04-29T07:05:40Z

← Older revision		Revision as of 07:05, 29 April 2020
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	==Crystal structure of M. tuberculosis InhA in complex with NAD+ and N-(3-(aminomethyl)phenyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide==		==Crystal structure of M. tuberculosis InhA in complex with NAD+ and N-(3-(aminomethyl)phenyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide==
	<StructureSection load='6sql' size='340' side='right'caption='[[6sql]]' scene=''>		<StructureSection load='6sql' size='340' side='right'caption='[[6sql]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sql]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SQL FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sql OCA], [http://pdbe.org/6sql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sql RCSB], [http://www.ebi.ac.uk/pdbsum/6sql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sql ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LTK:~{N}-[3-(aminomethyl)phenyl]-5-chloranyl-3-methyl-1-benzothiophene-2-sulfonamide'>LTK</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA, Rv1484, MTCY277.05 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sql OCA], [http://pdbe.org/6sql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sql RCSB], [http://www.ebi.ac.uk/pdbsum/6sql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sql ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Tuberculosis (TB) remains a leading cause of mortality among infectious diseases worldwide. InhA has been the focus of numerous drug discovery efforts as this is the target of the first line pro-drug isoniazid. However, with resistance to this drug becoming more common, the aim has been to find new clinical candidates that directly inhibit this enzyme and that do not require activation by the catalase peroxidase KatG, thus circumventing the majority of the resistance mechanisms. In this work, the screening and validation of a fragment library are described, and the development of the fragment hits using a fragment growing strategy was employed, which led to the development of InhA inhibitors with affinities of up to 250 nM.

			Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.,Sabbah M, Mendes V, Vistal RG, Dias DMG, Zahorszka M, Mikusova K, Kordulakova J, Coyne AG, Blundell TL, Abell C J Med Chem. 2020 Apr 15. doi: 10.1021/acs.jmedchem.0c00007. PMID:32240584<ref>PMID:32240584</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6sql" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Abell C]]		[[Category: Myctu]]
	[[Category: Blundell TL]]		[[Category: Abell, C]]
	[[Category: Coyne AG]]		[[Category: Blundell, T L]]
	[[Category: Mendes V]]		[[Category: Coyne, A G]]
	[[Category: Sabbah M]]		[[Category: Mendes, V]]
			[[Category: Sabbah, M]]
			[[Category: Inha]]
			[[Category: Oxidoreductase]]

OCA at 05:43, 22 April 2020

2020-04-22T05:43:28Z

← Older revision		Revision as of 05:43, 22 April 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6sql is ~~ON HOLD until Paper Publication~~		==Crystal structure of M. tuberculosis InhA in complex with NAD+ and N-(3-(aminomethyl)phenyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide==
			<StructureSection load='6sql' size='340' side='right'caption='[[6sql]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SQL FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sql OCA], [http://pdbe.org/6sql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sql RCSB], [http://www.ebi.ac.uk/pdbsum/6sql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sql ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Abell C]]
			[[Category: Blundell TL]]
			[[Category: Coyne AG]]
			[[Category: Mendes V]]
			[[Category: Sabbah M]]

OCA: Protected "6sql" [edit=sysop:move=sysop]

2019-10-02T07:36:31Z

Protected "6sql" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:36, 2 October 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6sql is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-10-02T07:36:29Z

New page: '''Unreleased structure''' The entry 6sql is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sql is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]