6suf - Revision history

OCA at 10:16, 22 May 2024

2024-05-22T10:16:47Z

← Older revision		Revision as of 10:16, 22 May 2024
Line 3:		Line 3:
	<SX load='6suf' size='340' side='right' viewer='molstar' caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6suf' size='340' side='right' viewer='molstar' caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_29999 Atcc 29999~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SUF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SUF FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6sue\|6sue]]</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.4Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999]), TccC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.~~cgi?mode=Info&srchmode=5~~&~~id=29488 ATCC 29999])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [https://pdbe.org/6suf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [https://www.ebi.ac.uk/pdbsum/6suf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [~~http~~://pdbe.org/6suf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6suf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9RN43_PHOLU Q9RN43_PHOLU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</SX>		</SX>
	~~[[Category: Atcc 29999]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Raunser, S]]~~		[[Category: Photorhabdus luminescens]]
	~~[[Category: Roderer, D]]~~		[[Category: Raunser S]]
	~~[[Category: Complex]]~~		[[Category: Roderer D]]
	~~[[Category: Holotoxin]]~~
	~~[[Category: Insecticidal]]~~
	[[Category: Photorhabdus]]
	[[Category: ~~Toxin~~]]
	[[Category: ~~Translocation~~]]

OCA at 06:18, 11 April 2020

2020-04-11T06:18:25Z

← Older revision		Revision as of 06:18, 11 April 2020
Line 3:		Line 3:
	<SX load='6suf' size='340' side='right' viewer='molstar' caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6suf' size='340' side='right' viewer='molstar' caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SUF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SUF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sue\|6sue]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sue\|6sue]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999]), TccC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999]), TccC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [http://pdbe.org/6suf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [http://www.ebi.ac.uk/pdbsum/6suf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [http://pdbe.org/6suf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [http://www.ebi.ac.uk/pdbsum/6suf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:55, 7 March 2020

2020-03-07T00:55:31Z

← Older revision		Revision as of 00:55, 7 March 2020
Line 1:		Line 1:

	==Structure of Photorhabdus luminescens Tc holotoxin pore==		==Structure of Photorhabdus luminescens Tc holotoxin pore==
	<~~StructureSection~~ load='6suf' size='340' side='right'caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6suf' size='340' side='right' viewer='molstar' caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SUF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SUF FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
	</~~StructureSection~~>		</SX>
	[[Category: Atcc 29999]]		[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:52, 13 November 2019

2019-11-13T11:52:29Z

← Older revision		Revision as of 11:52, 13 November 2019
Line 3:		Line 3:
	<StructureSection load='6suf' size='340' side='right'caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='6suf' size='340' side='right'caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SUF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29999 Atcc 29999]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SUF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sue\|6sue]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sue\|6sue]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcdA, tcdA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999]), TccC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29488 ATCC 29999])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [http://pdbe.org/6suf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [http://www.ebi.ac.uk/pdbsum/6suf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [http://pdbe.org/6suf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [http://www.ebi.ac.uk/pdbsum/6suf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Tc toxins are modular toxin systems of insect and human pathogenic bacteria. They are composed of a 1.4-MDa pentameric membrane translocator (TcA) and a 250-kDa cocoon (TcB and TcC) encapsulating the 30-kDa toxic enzyme (C terminus of TcC). Binding of Tc toxins to target cells and a pH shift trigger the conformational transition from the soluble prepore state to the membrane-embedded pore. Subsequently, the toxic enzyme is translocated and released into the cytoplasm. A high-resolution structure of a holotoxin embedded in membranes is missing, leaving open the question of whether TcB-TcC has an influence on the conformational transition of TcA. Here we show in atomic detail a fully assembled 1.7-MDa Tc holotoxin complex from Photorhabdus luminescens in the membrane. We find that the 5 TcA protomers conformationally adapt to fit around the cocoon during the prepore-to-pore transition. The architecture of the Tc toxin complex allows TcB-TcC to bind to an already membrane-embedded TcA pore to form a holotoxin. Importantly, assembly of the holotoxin at the membrane results in spontaneous translocation of the toxic enzyme, indicating that this process is not driven by a proton gradient or other energy source. Mammalian lipids with zwitterionic head groups are preferred over other lipids for the integration of Tc toxins. In a nontoxic Tc toxin variant, we can visualize part of the translocating toxic enzyme, which transiently interacts with alternating negative charges and hydrophobic stretches of the translocation channel, providing insights into the mechanism of action of Tc toxins.

			Structure of a Tc holotoxin pore provides insights into the translocation mechanism.,Roderer D, Hofnagel O, Benz R, Raunser S Proc Natl Acad Sci U S A. 2019 Oct 30. pii: 1909821116. doi:, 10.1073/pnas.1909821116. PMID:31666324<ref>PMID:31666324</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6suf" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Atcc 29999]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Raunser, S]]		[[Category: Raunser, S]]

OCA at 06:53, 6 November 2019

2019-11-06T06:53:28Z

← Older revision		Revision as of 06:53, 6 November 2019
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 6suf is ~~ON HOLD~~		==Structure of Photorhabdus luminescens Tc holotoxin pore==
			<StructureSection load='6suf' size='340' side='right'caption='[[6suf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[6suf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SUF FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sue\|6sue]]</td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6suf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6suf OCA], [http://pdbe.org/6suf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6suf RCSB], [http://www.ebi.ac.uk/pdbsum/6suf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6suf ProSAT]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Raunser, S]]
			[[Category: Roderer, D]]
			[[Category: Complex]]
			[[Category: Holotoxin]]
			[[Category: Insecticidal]]
			[[Category: Photorhabdus]]
			[[Category: Toxin]]
			[[Category: Translocation]]

OCA: Protected "6suf" [edit=sysop:move=sysop]

2019-10-02T07:49:12Z

Protected "6suf" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:49, 2 October 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6suf is ON HOLD Authors: Description: Category: Unreleased Structures

2019-10-02T07:49:10Z

New page: '''Unreleased structure''' The entry 6suf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6suf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]