6sys - Revision history

OCA at 12:50, 24 January 2024

2024-01-24T12:50:41Z

← Older revision		Revision as of 12:50, 24 January 2024
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	==Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2==		==Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2==
	<StructureSection load='6sys' size='340' side='right'caption='[[6sys]]' scene=''>		<StructureSection load='6sys' size='340' side='right'caption='[[6sys]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sys]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SYS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sys OCA], [~~http~~://pdbe.org/6sys PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sys RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sys PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sys ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LZW:(4~{S})-4-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1~{H}-cyclopenta[c]quinoline-8-sulfonamide'>LZW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sys OCA], [https://pdbe.org/6sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sys RCSB], [https://www.ebi.ac.uk/pdbsum/6sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sys ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>

			==See Also==
			*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Angeli A]]		[[Category: Angeli A]]
	[[Category: Ferraroni M]]		[[Category: Ferraroni M]]

OCA at 05:45, 14 October 2020

2020-10-14T05:45:30Z

← Older revision		Revision as of 05:45, 14 October 2020
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	~~'''Unreleased structure'''~~

	~~The entry 6sys is ON HOLD until Paper Publication~~		==Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2==
			<StructureSection load='6sys' size='340' side='right'caption='[[6sys]]' scene=''>
	~~Authors: Angeli, A., Ferraroni, M.~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SYS FirstGlance]. <br>
	~~Description:~~ Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sys OCA], [http://pdbe.org/6sys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sys RCSB], [http://www.ebi.ac.uk/pdbsum/6sys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sys ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Ferraroni, M~~]]		__TOC__
	[[Category: ~~Angeli, A~~]]		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Angeli A]]
			[[Category: Ferraroni M]]

OCA at 06:02, 22 July 2020

2020-07-22T06:02:47Z

← Older revision		Revision as of 06:02, 22 July 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6sys is ON HOLD		The entry 6sys is ON HOLD until Paper Publication

	Authors: Angeli, A., Ferraroni, M.		Authors: Angeli, A., Ferraroni, M.
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	Description: Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2		Description: Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Ferraroni, M]]
	[[Category: Angeli, A]]		[[Category: Angeli, A]]
	~~[[Category: Ferraroni, M]]~~

OCA: Protected "6sys" [edit=sysop:move=sysop]

2019-10-10T03:43:42Z

Protected "6sys" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:43, 10 October 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6sys is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclo...

2019-10-10T03:43:41Z

New page: '''Unreleased structure''' The entry 6sys is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclo...

New page

'''Unreleased structure'''

The entry 6sys is ON HOLD

Authors: Angeli, A., Ferraroni, M.

Description: Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2
[[Category: Unreleased Structures]]
[[Category: Angeli, A]]
[[Category: Ferraroni, M]]