6tle - Revision history

OCA at 13:04, 24 January 2024

2024-01-24T13:04:45Z

← Older revision		Revision as of 13:04, 24 January 2024
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	==Human Eg5 motor domain mutant E344K==		==Human Eg5 motor domain mutant E344K==
	<StructureSection load='6tle' size='340' side='right'caption='[[6tle]]' scene=''>		<StructureSection load='6tle' size='340' side='right'caption='[[6tle]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TLE FirstGlance]. <br>		<table><tr><td colspan='2'>[[6tle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TLE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tle OCA], [https://pdbe.org/6tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tle RCSB], [https://www.ebi.ac.uk/pdbsum/6tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tle ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tle OCA], [https://pdbe.org/6tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tle RCSB], [https://www.ebi.ac.uk/pdbsum/6tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tle ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>

			==See Also==
			*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Garcia-Saez I]]		[[Category: Garcia-Saez I]]
	[[Category: Skoufias DA]]		[[Category: Skoufias DA]]

OCA at 03:30, 2 July 2021

2021-07-02T03:30:32Z

← Older revision		Revision as of 03:30, 2 July 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6tle is ~~ON HOLD until Paper Publication~~		==Human Eg5 motor domain mutant E344K==
			<StructureSection load='6tle' size='340' side='right'caption='[[6tle]]' scene=''>
	~~Authors~~: ~~Garcia~~-~~Saez~~, I., ~~Skoufias~~, D.A.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TLE FirstGlance]. <br>
	~~Description: Human Eg5 motor domain mutant E344K~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tle OCA], [https://pdbe.org/6tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tle RCSB], [https://www.ebi.ac.uk/pdbsum/6tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tle ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Skoufias, D.A~~]]		__TOC__
	[[Category: ~~Garcia-Saez, I~~]]		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Garcia-Saez I]]
			[[Category: Skoufias DA]]

OCA: Protected "6tle" [edit=sysop:move=sysop]

2019-12-11T13:36:32Z

Protected "6tle" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:36, 11 December 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6tle is ON HOLD until Paper Publication Authors: Garcia-Saez, I., Skoufias, D.A. Description: Human Eg5 motor domain mutant E344K [[Category: Unrel...

2019-12-11T13:36:30Z

New page: '''Unreleased structure''' The entry 6tle is ON HOLD until Paper Publication Authors: Garcia-Saez, I., Skoufias, D.A. Description: Human Eg5 motor domain mutant E344K [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 6tle is ON HOLD until Paper Publication

Authors: Garcia-Saez, I., Skoufias, D.A.

Description: Human Eg5 motor domain mutant E344K
[[Category: Unreleased Structures]]
[[Category: Skoufias, D.A]]
[[Category: Garcia-Saez, I]]