6two - Revision history

OCA at 13:11, 24 January 2024

2024-01-24T13:11:03Z

← Older revision		Revision as of 13:11, 24 January 2024
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	<StructureSection load='6two' size='340' side='right'caption='[[6two]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='6two' size='340' side='right'caption='[[6two]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6two]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6two]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TWO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6two OCA], [~~http~~://pdbe.org/6two PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6two RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6two PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6two ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6two OCA], [https://pdbe.org/6two PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6two RCSB], [https://www.ebi.ac.uk/pdbsum/6two PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6two ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/C9WWY7_CLOBO C9WWY7_CLOBO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6two" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6two" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Botulinum neurotoxin 3D structures\|Botulinum neurotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus botulinus van ermengem 1896~~]]		[[Category: Clostridium botulinum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Acharya~~, K R~~]]		[[Category: Acharya KR]]
	[[Category: Britton, A]]		[[Category: Britton A]]
	[[Category: Davies~~, J R]]~~		[[Category: Davies JR]]
	~~[[Category: Binding domain]]~~
	~~[[Category: Botulinum neurotoxin]]~~
	~~[[Category: Toxin~~]]

OCA at 08:09, 2 December 2020

2020-12-02T08:09:55Z

← Older revision		Revision as of 08:09, 2 December 2020
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	==Binding domain of BoNT/A6==		==Binding domain of BoNT/A6==
	<StructureSection load='6two' size='340' side='right'caption='[[6two]]' scene=''>		<StructureSection load='6two' size='340' side='right'caption='[[6two]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6two]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TWO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6two OCA], [http://pdbe.org/6two PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6two RCSB], [http://www.ebi.ac.uk/pdbsum/6two PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6two ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6two OCA], [http://pdbe.org/6two PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6two RCSB], [http://www.ebi.ac.uk/pdbsum/6two PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6two ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding domain that targets neuronal cell membranes (HC ), a translocation domain (HN ), and a catalytic domain (LC). Here we present high-resolution crystal structures of the binding domains of BoNT subtypes /A5 (HC /A5) and /A6 (HC /A6). These structures show that the core fold identified in other subtypes is maintained, but with subtle differences at the expected receptor binding sites.

			High resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.,Davies JR, Britton A, Liu SM, Acharya KR FEBS Open Bio. 2020 Jul 11. doi: 10.1002/2211-5463.12931. PMID:32654405<ref>PMID:32654405</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6two" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus botulinus van ermengem 1896]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Acharya KR]]		[[Category: Acharya, K R]]
	[[Category: Britton A]]		[[Category: Britton, A]]
	[[Category: Davies JR]]		[[Category: Davies, J R]]
			[[Category: Binding domain]]
			[[Category: Botulinum neurotoxin]]
			[[Category: Toxin]]

OCA at 10:51, 22 July 2020

2020-07-22T10:51:13Z

← Older revision		Revision as of 10:51, 22 July 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6two is ~~ON HOLD~~		==Binding domain of BoNT/A6==
			<StructureSection load='6two' size='340' side='right'caption='[[6two]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TWO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TWO FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6two OCA], [http://pdbe.org/6two PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6two RCSB], [http://www.ebi.ac.uk/pdbsum/6two PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6two ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Acharya KR]]
			[[Category: Britton A]]
			[[Category: Davies JR]]

OCA: Protected "6two" [edit=sysop:move=sysop]

2020-01-22T14:02:30Z

Protected "6two" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:02, 22 January 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6two is ON HOLD Authors: Description: Category: Unreleased Structures

2020-01-22T14:02:27Z

New page: '''Unreleased structure''' The entry 6two is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6two is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]