6uff - Revision history

OCA at 07:50, 11 October 2023

2023-10-11T07:50:18Z

← Older revision		Revision as of 07:50, 11 October 2023
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	<StructureSection load='6uff' size='340' side='right'caption='[[6uff]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='6uff' size='340' side='right'caption='[[6uff]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6uff]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anabaena_7120 Anabaena~~ 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6UFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6uff]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_sp._PCC_7120_=_FACHB-418 Nostoc sp. PCC 7120 = FACHB-418]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UFF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.007Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~all1865 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=103690 Anabaena 7120])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uff OCA], [~~http~~://pdbe.org/6uff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6uff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6uff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6uff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uff OCA], [https://pdbe.org/6uff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uff RCSB], [https://www.ebi.ac.uk/pdbsum/6uff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uff ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8YVV8_NOSS1 Q8YVV8_NOSS1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Anabaena 7120]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Hyster, T~~]]		[[Category: Nostoc sp. PCC 7120 = FACHB-418]]
	[[Category: ~~Jeffrey, P D~~]]		[[Category: Hyster T]]
	[[Category: ~~Sandoval, B~~]]		[[Category: Jeffrey PD]]
	[[Category: ~~Alkene reductase]]~~		[[Category: Sandoval B]]
	~~[[Category: Cyanobacteria]]~~
	~~[[Category: Ene reductase]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 09:47, 1 April 2020

2020-04-01T09:47:25Z

← Older revision		Revision as of 09:47, 1 April 2020
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	<StructureSection load='6uff' size='340' side='right'caption='[[6uff]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='6uff' size='340' side='right'caption='[[6uff]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6uff]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6uff]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_7120 Anabaena 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">all1865 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=103690 Anabaena 7120])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uff OCA], [http://pdbe.org/6uff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uff RCSB], [http://www.ebi.ac.uk/pdbsum/6uff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uff OCA], [http://pdbe.org/6uff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uff RCSB], [http://www.ebi.ac.uk/pdbsum/6uff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uff ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Flavin-dependent 'ene'-reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Experimental evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution. DFT calculations reveal this radical to be "dynamically stable", suggesting it is sufficiently long lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic paradigms.

			Photoenzymatic Hydrogenation of Heteroaromatic Olefins using 'Ene'-Reductases with Photoredox Catalysts.,Hyster T, Nakano Y, Black MJ, Meichan AJ, Sandoval BA, Chung M, Biegasiewicz K, Zhu T Angew Chem Int Ed Engl. 2020 Mar 17. doi: 10.1002/anie.202003125. PMID:32181943<ref>PMID:32181943</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6uff" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Anabaena 7120]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hyster, T]]		[[Category: Hyster, T]]

OCA at 10:23, 27 March 2020

2020-03-27T10:23:04Z

← Older revision		Revision as of 10:23, 27 March 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6uff is ~~ON HOLD until Paper Publication~~		==Structure of Ene-reductase 1 NostocER1 from cyanobacteria==
			<StructureSection load='6uff' size='340' side='right'caption='[[6uff]], [[Resolution\|resolution]] 2.01Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[6uff]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFF FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uff OCA], [http://pdbe.org/6uff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uff RCSB], [http://www.ebi.ac.uk/pdbsum/6uff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uff ProSAT]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Hyster, T]]
			[[Category: Jeffrey, P D]]
			[[Category: Sandoval, B]]
			[[Category: Alkene reductase]]
			[[Category: Cyanobacteria]]
			[[Category: Ene reductase]]
			[[Category: Oxidoreductase]]

OCA at 13:22, 29 January 2020

2020-01-29T13:22:16Z

← Older revision		Revision as of 13:22, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6uff is ON HOLD		The entry 6uff is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6uff" [edit=sysop:move=sysop]

2019-10-02T08:46:13Z

Protected "6uff" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:46, 2 October 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6uff is ON HOLD Authors: Description: Category: Unreleased Structures

2019-10-02T08:46:12Z

New page: '''Unreleased structure''' The entry 6uff is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6uff is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]