6ulz - Revision history

OCA at 07:54, 11 October 2023

2023-10-11T07:54:14Z

← Older revision		Revision as of 07:54, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_10027 Atcc 10027~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lgrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [~~http~~://pdbe.org/6ulz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [https://pdbe.org/6ulz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [https://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA]] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.		[https://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6ulz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ulz" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Linear gramicidin synthase\|Linear gramicidin synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 10027~~]]		[[Category: Brevibacillus parabrevis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Alonzo~~, D A~~]]		[[Category: Alonzo DA]]
	[[Category: Chiche-Lapierre, C]]		[[Category: Chiche-Lapierre C]]
	[[Category: Schmeing~~, T M]]~~		[[Category: Schmeing TM]]
	~~[[Category: Adenylate]]~~
	~~[[Category: Adenylation]]~~
	~~[[Category: Adenylation domain]]~~
	~~[[Category: Biosynthetic protein]]~~
	~~[[Category: Natural product]]~~
	~~[[Category: Non-ribosomal peptide synthetase]]~~
	~~[[Category: Nonribosomal peptide synthetase]]~~
	~~[[Category: Nrp~~]]

OCA at 06:37, 6 May 2020

2020-05-06T06:37:01Z

← Older revision		Revision as of 06:37, 6 May 2020
Line 3:		Line 3:
	<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10027 Atcc 10027]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10027 Atcc 10027]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lgrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lgrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [http://pdbe.org/6ulz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [http://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [http://pdbe.org/6ulz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [http://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:21, 4 March 2020

2020-03-04T07:21:47Z

← Older revision		Revision as of 07:21, 4 March 2020
Line 3:		Line 3:
	<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10027 Atcc 10027]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lgrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [http://pdbe.org/6ulz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [http://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [http://pdbe.org/6ulz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [http://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA]] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.		[[http://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA]] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Nonribosomal depsipeptides are natural products composed of amino and hydroxy acid residues. The hydroxy acid residues often derive from alpha-keto acids, reduced by ketoreductase domains in the depsipeptide synthetases. Biochemistry and structures reveal the mechanism of discrimination for alpha-keto acids and a remarkable architecture: flanking intact adenylation and ketoreductase domains are sequences separated by >1,100 residues that form a split 'pseudoAsub' domain, structurally important for the depsipeptide module's synthetic cycle.

			Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis.,Alonzo DA, Chiche-Lapierre C, Tarry MJ, Wang J, Schmeing TM Nat Chem Biol. 2020 Feb 17. pii: 10.1038/s41589-020-0481-5. doi:, 10.1038/s41589-020-0481-5. PMID:32066969<ref>PMID:32066969</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6ulz" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Atcc 10027]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Alonzo, D A]]		[[Category: Alonzo, D A]]

OCA at 06:43, 19 February 2020

2020-02-19T06:43:06Z

@@ Line 1: / Line 1: @@
-The entry 6ulz is ON HOLD  until Paper Publication
+==Adenylation domain of the initiation module of LgrA mutant P483M==
+<StructureSection load='6ulz' size='340' side='right'caption='[[6ulz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ulz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ULZ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulz OCA], [http://pdbe.org/6ulz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulz RCSB], [http://www.ebi.ac.uk/pdbsum/6ulz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulz ProSAT]</span></td></tr>

OCA at 07:36, 30 October 2019

2019-10-30T07:36:51Z

← Older revision		Revision as of 07:36, 30 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6ulz is ON HOLD		The entry 6ulz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ulz" [edit=sysop:move=sysop]

2019-10-16T04:40:18Z

Protected "6ulz" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:40, 16 October 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6ulz is ON HOLD Authors: Description: Category: Unreleased Structures

2019-10-16T04:40:16Z

New page: '''Unreleased structure''' The entry 6ulz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ulz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]