6usr - Revision history

OCA at 07:57, 11 October 2023

2023-10-11T07:57:37Z

← Older revision		Revision as of 07:57, 11 October 2023
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	<StructureSection load='6usr' size='340' side='right'caption='[[6usr]], [[Resolution\|resolution]] 2.93Å' scene=''>		<StructureSection load='6usr' size='340' side='right'caption='[[6usr]], [[Resolution\|resolution]] 2.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6usr]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Red_flour_beetle Red flour beetle~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6USR FirstGlance]. <br>		<table><tr><td colspan='2'>[[6usr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tribolium_castaneum Tribolium castaneum] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6USR FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>~~, ~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.93Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TERT, TcasGA2_TC010963 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=7070 Red flour beetle])</td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usr OCA], [https://pdbe.org/6usr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6usr RCSB], [https://www.ebi.ac.uk/pdbsum/6usr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6usr ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usr OCA], [~~http~~://pdbe.org/6usr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6usr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6usr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6usr ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q0QHL8_TRICA Q0QHL8_TRICA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Telomerase\|Telomerase]]		*[[Telomerase 3D structures\|Telomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~RNA-directed DNA polymerase~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Red flour beetle~~]]		[[Category: Tribolium castaneum]]
	[[Category: Freudenthal~~, B D~~]]		[[Category: Freudenthal BD]]
	[[Category: Schaich~~, M A]]~~		[[Category: Schaich MA]]
	~~[[Category: Nuclear protein]]~~
	~~[[Category: Polymerase]]~~
	~~[[Category: Reverse transcriptase]]~~
	~~[[Category: Telomerase]]~~
	~~[[Category: Transferase-rna-dna complex~~]]

OCA at 09:03, 6 January 2021

2021-01-06T09:03:53Z

← Older revision		Revision as of 09:03, 6 January 2021
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	==Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp==		==Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp==
	<StructureSection load='6usr' size='340' side='right'caption='[[6usr]]' scene=''>		<StructureSection load='6usr' size='340' side='right'caption='[[6usr]], [[Resolution\|resolution]] 2.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6USR FirstGlance]. <br>		<table><tr><td colspan='2'>[[6usr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Red_flour_beetle Red flour beetle]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6USR FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usr OCA], [http://pdbe.org/6usr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6usr RCSB], [http://www.ebi.ac.uk/pdbsum/6usr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6usr ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT, TcasGA2_TC010963 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7070 Red flour beetle])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usr OCA], [http://pdbe.org/6usr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6usr RCSB], [http://www.ebi.ac.uk/pdbsum/6usr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6usr ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for the proper capping of telomeric sequences by shelterin. Unfortunately, how telomerase selects correct nucleotides is unknown. Here, we determined structures of Tribolium castaneum telomerase reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coordination, triphosphate binding, and RNA template stabilization. We found that TERT inserts a mismatch or ribonucleotide ~1 in 10,000 and ~1 in 14,000 insertion events, respectively. At biological ribonucleotide concentrations, these rates translate to ~40 ribonucleotides inserted per 10 kilobases. Human telomerase assays determined a conserved tyrosine steric gate regulates ribonucleotide insertion into telomeres. Cumulatively, our work provides insight into how telomerase selects the proper nucleotide to maintain telomere integrity.

			Mechanisms of nucleotide selection by telomerase.,Schaich MA, Sanford SL, Welfer GA, Johnson SA, Khoang TH, Opresko PL, Freudenthal BD Elife. 2020 Jun 5;9. pii: 55438. doi: 10.7554/eLife.55438. PMID:32501800<ref>PMID:32501800</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6usr" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Telomerase\|Telomerase]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Freudenthal BD]]		[[Category: RNA-directed DNA polymerase]]
	[[Category: Schaich MA]]		[[Category: Red flour beetle]]
			[[Category: Freudenthal, B D]]
			[[Category: Schaich, M A]]
			[[Category: Nuclear protein]]
			[[Category: Polymerase]]
			[[Category: Reverse transcriptase]]
			[[Category: Telomerase]]
			[[Category: Transferase-rna-dna complex]]

OCA at 10:12, 17 June 2020

2020-06-17T10:12:43Z

← Older revision		Revision as of 10:12, 17 June 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6usr is ~~ON HOLD until Paper Publication~~		==Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp==
			<StructureSection load='6usr' size='340' side='right'caption='[[6usr]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6USR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6USR FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6usr OCA], [http://pdbe.org/6usr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6usr RCSB], [http://www.ebi.ac.uk/pdbsum/6usr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6usr ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Freudenthal BD]]
			[[Category: Schaich MA]]

OCA at 04:49, 10 June 2020

2020-06-10T04:49:05Z

← Older revision		Revision as of 04:49, 10 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6usr is ON HOLD		The entry 6usr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:07, 3 June 2020

2020-06-03T05:07:08Z

← Older revision		Revision as of 05:07, 3 June 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6usr is ON HOLD ~~until Paper Publication~~		The entry 6usr is ON HOLD

	Authors:		Authors:

OCA at 05:58, 18 December 2019

2019-12-18T05:58:46Z

← Older revision		Revision as of 05:58, 18 December 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6usr is ON HOLD		The entry 6usr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6usr" [edit=sysop:move=sysop]

2019-11-06T05:20:14Z

Protected "6usr" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:20, 6 November 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6usr is ON HOLD Authors: Description: Category: Unreleased Structures

2019-11-06T05:20:13Z

New page: '''Unreleased structure''' The entry 6usr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6usr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]