7aaa - Revision history

OCA at 07:44, 1 May 2024

2024-05-01T07:44:02Z

← Older revision		Revision as of 07:44, 1 May 2024
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	==Crystal structure of the catalytic domain of human PARP1 (apo)==		==Crystal structure of the catalytic domain of human PARP1 (apo)==
	<StructureSection load='7aaa' size='340' side='right'caption='[[7aaa]]' scene=''>		<StructureSection load='7aaa' size='340' side='right'caption='[[7aaa]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[7aaa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AAA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aaa OCA], [https://pdbe.org/7aaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aaa RCSB], [https://www.ebi.ac.uk/pdbsum/7aaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aaa ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.74Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aaa OCA], [https://pdbe.org/7aaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aaa RCSB], [https://www.ebi.ac.uk/pdbsum/7aaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aaa ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

			==See Also==
			*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Easton LE]]		[[Category: Easton LE]]

OCA at 17:53, 10 March 2021

2021-03-10T17:53:54Z

← Older revision		Revision as of 17:53, 10 March 2021
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	<StructureSection load='7aaa' size='340' side='right'caption='[[7aaa]]' scene=''>		<StructureSection load='7aaa' size='340' side='right'caption='[[7aaa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AAA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7AAA FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AAA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aaa OCA], [~~http~~://pdbe.org/7aaa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7aaa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7aaa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7aaa ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aaa OCA], [https://pdbe.org/7aaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aaa RCSB], [https://www.ebi.ac.uk/pdbsum/7aaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aaa ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 05:52, 20 January 2021

2021-01-20T05:52:09Z

← Older revision		Revision as of 05:52, 20 January 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7aaa is ~~ON HOLD until Paper Publication~~		==Crystal structure of the catalytic domain of human PARP1 (apo)==
			<StructureSection load='7aaa' size='340' side='right'caption='[[7aaa]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AAA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7AAA FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aaa OCA], [http://pdbe.org/7aaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7aaa RCSB], [http://www.ebi.ac.uk/pdbsum/7aaa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7aaa ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Easton LE]]
			[[Category: Embrey KJ]]
			[[Category: Johannes JW]]
			[[Category: Neuhaus D]]
			[[Category: Ogden TEH]]
			[[Category: Rawlins PB]]
			[[Category: Schimpl M]]
			[[Category: Underwood E]]
			[[Category: Yang J-C]]

OCA at 04:22, 7 October 2020

2020-10-07T04:22:10Z

← Older revision		Revision as of 04:22, 7 October 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7aaa is ON HOLD		The entry 7aaa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7aaa" [edit=sysop:move=sysop]

2020-09-09T07:23:53Z

Protected "7aaa" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:23, 9 September 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7aaa is ON HOLD Authors: Description: Category: Unreleased Structures

2020-09-09T07:23:52Z

New page: '''Unreleased structure''' The entry 7aaa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7aaa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]