7be2 - Revision history

OCA at 06:07, 21 November 2024

2024-11-21T06:07:47Z

← Older revision		Revision as of 06:07, 21 November 2024
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	<StructureSection load='7be2' size='340' side='right'caption='[[7be2]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='7be2' size='340' side='right'caption='[[7be2]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[7be2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BE2 FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BE2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RH:RHODIUM'>RH</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RH:RHODIUM'>RH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7be2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7be2 OCA], [https://pdbe.org/7be2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7be2 RCSB], [https://www.ebi.ac.uk/pdbsum/7be2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7be2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7be2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7be2 OCA], [https://pdbe.org/7be2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7be2 RCSB], [https://www.ebi.ac.uk/pdbsum/7be2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7be2 ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Gallus gallus]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ferraro G]]		[[Category: Ferraro G]]
	[[Category: Loreto D]]		[[Category: Loreto D]]
	[[Category: Merlino A]]		[[Category: Merlino A]]

OCA at 12:26, 1 February 2024

2024-02-01T12:26:37Z

← Older revision		Revision as of 12:26, 1 February 2024
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	==X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6)==		==X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6)==
	<StructureSection load='7be2' size='340' side='right'caption='[[7be2]]' scene=''>		<StructureSection load='7be2' size='340' side='right'caption='[[7be2]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BE2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7be2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BE2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7be2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7be2 OCA], [https://pdbe.org/7be2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7be2 RCSB], [https://www.ebi.ac.uk/pdbsum/7be2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7be2 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RH:RHODIUM'>RH</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7be2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7be2 OCA], [https://pdbe.org/7be2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7be2 RCSB], [https://www.ebi.ac.uk/pdbsum/7be2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7be2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The structures of the adducts formed upon reaction of the cytotoxic paddlewheel dirhodium complex [Rh2(mu-O2CCH3)4] with the model protein hen egg white lysozyme (HEWL) under different experimental conditions are reported. Results indicate that [Rh2(mu-O2CCH3)4] extensively reacts with HEWL:it in part breaks down, at variance with what happens in reactions with other proteins. A Rh center coordinates the side chains of Arg14 and His15. Dimeric Rh-Rh units with Rh-Rh distances between 2.3 and 2.5 A are bound to the side chains of Asp18, Asp101, Asn93, and Lys96, while a dirhodium unit with a Rh-Rh distance of 3.2-3.4 A binds the C-terminal carboxylate and the side chain of Lys13 at the interface between two symmetry-related molecules. An additional monometallic fragment binds the side chain of Lys33. These data, which are supported by replicated structural determinations, shed light on the reactivity of dirhodium tetracarboxylates with proteins, providing useful information for the design of new Rh-containing biomaterials with an array of potential applications in the field of catalysis or of medicinal chemistry and valuable insight into the mechanism of action of these potential anticancer agents.

			Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme.,Loreto D, Ferraro G, Merlino A Int J Mol Sci. 2021 Feb 2;22(3). pii: ijms22031496. doi: 10.3390/ijms22031496. PMID:33540880<ref>PMID:33540880</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7be2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ferraro G]]		[[Category: Ferraro G]]
	[[Category: Loreto D]]		[[Category: Loreto D]]
	[[Category: Merlino A]]		[[Category: Merlino A]]

OCA at 06:39, 24 February 2021

2021-02-24T06:39:52Z

← Older revision		Revision as of 06:39, 24 February 2021
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	~~'''Unreleased structure'''~~

	~~The entry 7be2 is ON HOLD until Paper Publication~~		==X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6)==
			<StructureSection load='7be2' size='340' side='right'caption='[[7be2]]' scene=''>
	~~Authors: Loreto, D., Merlino, A., Ferraro, G.~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BE2 FirstGlance]. <br>
	~~Description:~~ X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6)		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7be2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7be2 OCA], [https://pdbe.org/7be2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7be2 RCSB], [https://www.ebi.ac.uk/pdbsum/7be2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7be2 ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Ferraro, G]]		__TOC__
	[[Category: Loreto, D]]		</StructureSection>
	[[Category: Merlino, A]]		[[Category: Large Structures]]
			[[Category: Ferraro G]]
			[[Category: Loreto D]]
			[[Category: Merlino A]]

OCA at 06:37, 20 January 2021

2021-01-20T06:37:29Z

← Older revision		Revision as of 06:37, 20 January 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7be2 is ON HOLD		The entry 7be2 is ON HOLD until Paper Publication

	Authors: Loreto, D., Merlino, A., Ferraro, G.		Authors: Loreto, D., Merlino, A., Ferraro, G.

OCA: Protected "7be2" [edit=sysop:move=sysop]

2020-12-30T05:18:51Z

Protected "7be2" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:18, 30 December 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7be2 is ON HOLD Authors: Loreto, D., Merlino, A., Ferraro, G. Description: X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6...

2020-12-30T05:18:50Z

New page: '''Unreleased structure''' The entry 7be2 is ON HOLD Authors: Loreto, D., Merlino, A., Ferraro, G. Description: X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6...

New page

'''Unreleased structure'''

The entry 7be2 is ON HOLD

Authors: Loreto, D., Merlino, A., Ferraro, G.

Description: X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6)
[[Category: Unreleased Structures]]
[[Category: Ferraro, G]]
[[Category: Loreto, D]]
[[Category: Merlino, A]]