7bps - Revision history

OCA at 10:53, 23 October 2024

2024-10-23T10:53:43Z

← Older revision		Revision as of 10:53, 23 October 2024
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	<StructureSection load='7bps' size='340' side='right'caption='[[7bps]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='7bps' size='340' side='right'caption='[[7bps]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[7bps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BPS FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BPS FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bps OCA], [https://pdbe.org/7bps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bps RCSB], [https://www.ebi.ac.uk/pdbsum/7bps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bps OCA], [https://pdbe.org/7bps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bps RCSB], [https://www.ebi.ac.uk/pdbsum/7bps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bps ProSAT]</span></td></tr>
	</table>		</table>
	== ~~Function~~ ==		<div style="background-color:#fffaf0;">
	~~[https:~~/~~/www~~.~~uniprot~~.~~org/uniprot/TX101_MOUSE TX101_MOUSE] Plays a~~ role in fertilization ~~by controlling binding of sperm~~ to ~~zona pellucida~~ and ~~migration~~ of ~~spermatozoa into~~ the ~~oviduct probably through molecule adhesion ADAM3~~ (~~PubMed~~:~~23633567, PubMed~~:~~23969891)~~. ~~May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity)~~.~~[UniProtKB~~:~~Q924B5]~~<ref>PMID:~~23633567~~</ref> <~~ref~~>~~PMID~~:~~23969891~~</~~ref~~>		== Publication Abstract from PubMed ==
			Testis-expressed gene 101 (TEX101) is a glycosyl-phosphatidylinositol-anchored glycoprotein essential for sperm fertility and spermatogenesis. TEX101 interacts with lymphocyte antigen 6 complex, locus K (Ly6k) as well as a disintegrin and metallopeptidase domain 3 (ADAM3). Although these proteins are considered essential for fertility, the associated mechanisms remain uncharacterized. Herein, we determined the crystal structure of human and mouse TEX101, revealing that TEX101 contains two tandem Ly6/uPAR (LU) domains. Detailed structural analyses revealed characteristic surfaces of TEX101 that may be involved in the interactions with other proteins or membranes. These results provide the structural basis for the role of TEX101 in fertilization and could contribute to developing diagnostic methods and treatments for infertility or developing male contraceptives.

			Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains.,Masutani M, Sakurai S, Shimizu T, Ohto U FEBS Lett. 2020 Sep;594(18):3020-3031. doi: 10.1002/1873-3468.13875. Epub 2020, Jul 14. PMID:32608065<ref>PMID:32608065</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7bps" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Mus musculus]]~~
	[[Category: Masutani M]]		[[Category: Masutani M]]
	[[Category: Ohto U]]		[[Category: Ohto U]]
	[[Category: Sakurai S]]		[[Category: Sakurai S]]
	[[Category: Shimizu T]]		[[Category: Shimizu T]]

OCA at 07:11, 3 April 2024

2024-04-03T07:11:17Z

← Older revision		Revision as of 07:11, 3 April 2024
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	==Crystal structure of mouse TEX101==		==Crystal structure of mouse TEX101==
	<StructureSection load='7bps' size='340' side='right'caption='[[7bps]]' scene=''>		<StructureSection load='7bps' size='340' side='right'caption='[[7bps]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BPS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7BPS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7bps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BPS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7bps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bps OCA], [~~http~~://pdbe.org/7bps PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7bps RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7bps PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7bps ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bps OCA], [https://pdbe.org/7bps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bps RCSB], [https://www.ebi.ac.uk/pdbsum/7bps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bps ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/TX101_MOUSE TX101_MOUSE] Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct probably through molecule adhesion ADAM3 (PubMed:23633567, PubMed:23969891). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).[UniProtKB:Q924B5]<ref>PMID:23633567</ref> <ref>PMID:23969891</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
			[[Category: Mus musculus]]
	[[Category: Masutani M]]		[[Category: Masutani M]]
	[[Category: Ohto U]]		[[Category: Ohto U]]
	[[Category: Sakurai S]]		[[Category: Sakurai S]]
	[[Category: Shimizu T]]		[[Category: Shimizu T]]

OCA at 11:05, 24 December 2020

2020-12-24T11:05:20Z

← Older revision		Revision as of 11:05, 24 December 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7bps is ~~ON HOLD until Paper Publication~~		==Crystal structure of mouse TEX101==
			<StructureSection load='7bps' size='340' side='right'caption='[[7bps]]' scene=''>
	~~Authors~~: ~~Masutani~~, M., ~~Sakurai~~, S., ~~Shimizu~~, T.~~, Ohto, U~~.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BPS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BPS FirstGlance]. <br>
	~~Description: Crystal structure of mouse TEX101~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bps OCA], [http://pdbe.org/7bps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bps RCSB], [http://www.ebi.ac.uk/pdbsum/7bps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bps ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Ohto, U~~]]		__TOC__
	[[Category: ~~Masutani, M~~]]		</StructureSection>
	[[Category: ~~Shimizu, T~~]]		[[Category: Large Structures]]
	[[Category: ~~Sakurai, S~~]]		[[Category: Masutani M]]
			[[Category: Ohto U]]
			[[Category: Sakurai S]]
			[[Category: Shimizu T]]

OCA at 05:23, 3 June 2020

2020-06-03T05:23:05Z

← Older revision		Revision as of 05:23, 3 June 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7bps is ON HOLD		The entry 7bps is ON HOLD until Paper Publication

	Authors: Masutani, M., Sakurai, S., Shimizu, T., Ohto, U.		Authors: Masutani, M., Sakurai, S., Shimizu, T., Ohto, U.

OCA: Protected "7bps" [edit=sysop:move=sysop]

2020-04-01T07:52:42Z

Protected "7bps" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:52, 1 April 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7bps is ON HOLD Authors: Masutani, M., Sakurai, S., Shimizu, T., Ohto, U. Description: Crystal structure of mouse TEX101 [[Category: Unreleased Str...

2020-04-01T07:52:41Z

New page: '''Unreleased structure''' The entry 7bps is ON HOLD Authors: Masutani, M., Sakurai, S., Shimizu, T., Ohto, U. Description: Crystal structure of mouse TEX101 [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 7bps is ON HOLD

Authors: Masutani, M., Sakurai, S., Shimizu, T., Ohto, U.

Description: Crystal structure of mouse TEX101
[[Category: Unreleased Structures]]
[[Category: Ohto, U]]
[[Category: Masutani, M]]
[[Category: Shimizu, T]]
[[Category: Sakurai, S]]