7csv - Revision history

OCA at 16:15, 29 November 2023

2023-11-29T16:15:44Z

← Older revision		Revision as of 16:15, 29 November 2023
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	<StructureSection load='7csv' size='340' side='right'caption='[[7csv]], [[Resolution\|resolution]] 1.71Å' scene=''>		<StructureSection load='7csv' size='340' side='right'caption='[[7csv]], [[Resolution\|resolution]] 1.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7csv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[7csv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSV FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PA4674 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=208964 PSEAE])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.71Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csv OCA], [https://pdbe.org/7csv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csv RCSB], [https://www.ebi.ac.uk/pdbsum/7csv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csv OCA], [https://pdbe.org/7csv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csv RCSB], [https://www.ebi.ac.uk/pdbsum/7csv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csv ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9HVC1_PSEAE Q9HVC1_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pseae~~]]		[[Category: Pseudomonas aeruginosa PAO1]]
	[[Category: Bao, R]]		[[Category: Bao R]]
	[[Category: Luo~~, G H~~]]		[[Category: Luo GH]]
	[[Category: Song~~, Y J]]~~		[[Category: Song YJ]]
	~~[[Category: Antitoxin]]~~
	~~[[Category: Dimer~~]]

OCA at 07:11, 7 April 2021

2021-04-07T07:11:48Z

← Older revision		Revision as of 07:11, 7 April 2021
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	==Pseudomonas aeruginosa antitoxin HigA==		==Pseudomonas aeruginosa antitoxin HigA==
	<StructureSection load='7csv' size='340' side='right'caption='[[7csv]]' scene=''>		<StructureSection load='7csv' size='340' side='right'caption='[[7csv]], [[Resolution\|resolution]] 1.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7CSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[7csv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSV FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csv OCA], [~~http~~://pdbe.org/7csv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7csv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7csv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7csv ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA4674 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csv OCA], [https://pdbe.org/7csv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csv RCSB], [https://www.ebi.ac.uk/pdbsum/7csv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csv ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Type II toxin-antitoxin (TA) systems modulate many essential cellular processes in prokaryotic organisms. Recent studies indicate certain type II antitoxins also transcriptionally regulate other genes, besides neutralizing toxin activity. Herein, we investigated the diverse transcriptional repression properties of type II TA antitoxin PaHigA from Pseudomonas aeruginosa. Biochemical and functional analyses showed that PaHigA recognized variable pseudopalindromic DNA sequences and repressed expression of multiple genes. Furthermore, we presented high resolution structures of apo-PaHigA, PaHigA-PhigBA and PaHigA-Ppa2440 complex, describing how the rearrangements of the HTH domain accounted for the different DNA-binding patterns among HigA homologues. Moreover, we demonstrated that the N-terminal loop motion of PaHigA was associated with its apo and DNA-bound states, reflecting a switch mechanism regulating HigA antitoxin function. Collectively, this work extends our understanding of how the PaHigB/HigA system regulates multiple metabolic pathways to balance the growth and stress response in P. aeruginosa and could guide further development of anti-TA oriented strategies for pathogen treatment.

			Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs.,Song Y, Luo G, Zhu Y, Li T, Li C, He L, Zhao N, Zhao C, Yang J, Huang Q, Mu X, Tang X, Kang M, Wu S, He Y, Bao R Environ Microbiol. 2020 Dec 21. doi: 10.1111/1462-2920.15365. PMID:33346387<ref>PMID:33346387</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7csv" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bao R]]		[[Category: Pseae]]
	[[Category: Luo GH]]		[[Category: Bao, R]]
	[[Category: Song YJ]]		[[Category: Luo, G H]]
			[[Category: Song, Y J]]
			[[Category: Antitoxin]]
			[[Category: Dimer]]

OCA at 05:55, 20 January 2021

2021-01-20T05:55:22Z

← Older revision		Revision as of 05:55, 20 January 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7csv is ~~ON HOLD until Aug 17 2022~~		==Pseudomonas aeruginosa antitoxin HigA==
			<StructureSection load='7csv' size='340' side='right'caption='[[7csv]]' scene=''>
	~~Authors~~: ~~Song~~, Y.J., ~~Luo~~, G.H., ~~Bao~~, R.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CSV FirstGlance]. <br>
	~~Description: Pseudomonas aeruginosa antitoxin HigA~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csv OCA], [http://pdbe.org/7csv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7csv RCSB], [http://www.ebi.ac.uk/pdbsum/7csv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7csv ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Luo, G.H~~]]		__TOC__
	[[Category: ~~Song, Y.J~~]]		</StructureSection>
	[[Category: ~~Bao, R~~]]		[[Category: Large Structures]]
			[[Category: Bao R]]
			[[Category: Luo GH]]
			[[Category: Song YJ]]

OCA at 05:11, 2 September 2020

2020-09-02T05:11:20Z

← Older revision		Revision as of 05:11, 2 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7csv is ON HOLD		The entry 7csv is ON HOLD until Aug 17 2022

	Authors: Song, Y.J., Luo, G.H., Bao, R.		Authors: Song, Y.J., Luo, G.H., Bao, R.
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	Description: Pseudomonas aeruginosa antitoxin HigA		Description: Pseudomonas aeruginosa antitoxin HigA
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Luo, G.H]]
	[[Category: Song, Y.J]]		[[Category: Song, Y.J]]
	[[Category: Bao, R]]		[[Category: Bao, R]]
	~~[[Category: Luo, G.H]]~~

OCA: Protected "7csv" [edit=sysop:move=sysop]

2020-08-26T09:26:26Z

Protected "7csv" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:26, 26 August 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7csv is ON HOLD Authors: Song, Y.J., Luo, G.H., Bao, R. Description: Pseudomonas aeruginosa antitoxin HigA Category: Unreleased Structures [[Ca...

2020-08-26T09:26:24Z

New page: '''Unreleased structure''' The entry 7csv is ON HOLD Authors: Song, Y.J., Luo, G.H., Bao, R. Description: Pseudomonas aeruginosa antitoxin HigA Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 7csv is ON HOLD

Authors: Song, Y.J., Luo, G.H., Bao, R.

Description: Pseudomonas aeruginosa antitoxin HigA
[[Category: Unreleased Structures]]
[[Category: Song, Y.J]]
[[Category: Bao, R]]
[[Category: Luo, G.H]]