7cus - Revision history

OCA at 10:56, 23 October 2024

2024-10-23T10:56:06Z

← Older revision		Revision as of 10:56, 23 October 2024
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	<StructureSection load='7cus' size='340' side='right'caption='[[7cus]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='7cus' size='340' side='right'caption='[[7cus]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[7cus]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [https://pdbe.org/7cus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [https://www.ebi.ac.uk/pdbsum/7cus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [https://pdbe.org/7cus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [https://www.ebi.ac.uk/pdbsum/7cus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	~~[https://www.uniprot.org/uniprot/Q87HP3_VIBPA Q87HP3_VIBPA]~~
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Vibrio parahaemolyticus]]~~
	[[Category: Cho SY]]		[[Category: Cho SY]]
	[[Category: Yoon SI]]		[[Category: Yoon SI]]

OCA at 16:16, 29 November 2023

2023-11-29T16:16:42Z

← Older revision		Revision as of 16:16, 29 November 2023
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	<StructureSection load='7cus' size='340' side='right'caption='[[7cus]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='7cus' size='340' side='right'caption='[[7cus]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7cus]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"oceanomonas_parahaemolytica"_(fujino_et_al._1951)_miyamoto_et_al._1961 "oceanomonas parahaemolytica" (fujino et al. 1951) miyamoto et al. 1961~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7cus]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~C1S91_03980~~, ~~CGH73_12765, CGI34_20575, CGI42_14745, E4P16_22270, F0L89_03255 (~~[~~http://www.ncbi~~.~~nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=670 "Oceanomonas parahaemolytica" (Fujino et al. 1951) Miyamoto et al. 1961])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [~~http~~://pdbe.org/7cus PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7cus PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [https://pdbe.org/7cus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [https://www.ebi.ac.uk/pdbsum/7cus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q87HP3_VIBPA Q87HP3_VIBPA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Cho, S Y~~]]		[[Category: Vibrio parahaemolyticus]]
	[[Category: ~~Yoon, S I~~]]		[[Category: Cho SY]]
	[[Category: ~~Beta-lactam antibiotic receptor]]~~		[[Category: Yoon SI]]
	~~[[Category: Sensor domain]]~~
	~~[[Category: Signaling protein~~]]

OCA at 20:55, 28 October 2020

2020-10-28T20:55:55Z

← Older revision		Revision as of 20:55, 28 October 2020
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	==Crystal structure of the sensor domain of VbrK from Vibrio parahaemolyticus==		==Crystal structure of the sensor domain of VbrK from Vibrio parahaemolyticus==
	<StructureSection load='7cus' size='340' side='right'caption='[[7cus]]' scene=''>		<StructureSection load='7cus' size='340' side='right'caption='[[7cus]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7cus]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"oceanomonas_parahaemolytica"_(fujino_et_al._1951)_miyamoto_et_al._1961 "oceanomonas parahaemolytica" (fujino et al. 1951) miyamoto et al. 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [http://pdbe.org/7cus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [http://www.ebi.ac.uk/pdbsum/7cus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S91_03980, CGH73_12765, CGI34_20575, CGI42_14745, E4P16_22270, F0L89_03255 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=670 "Oceanomonas parahaemolytica" (Fujino et al. 1951) Miyamoto et al. 1961])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [http://pdbe.org/7cus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [http://www.ebi.ac.uk/pdbsum/7cus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Bacteria express beta-lactamase to counteract the bactericidal effects of beta-lactam antibiotics, which are the most widely employed antibacterial drugs. In gram-negative bacteria, the expression of beta-lactamase is generally regulated in response to the muropeptide that is generated from the peptidoglycan of the cell wall during beta-lactam antibiotic challenge. The direct regulation of beta-lactamase expression by beta-lactams was recently reported in Vibrio parahaemolyticus, and this regulation is mediated by a two-component regulatory system that consists of the histidine kinase VbrK and the response regulator VbrR. VbrK directly recognizes beta-lactam antibiotics using the periplasmic sensor domain (VbrK(SD)), a PF11884 Pfam family member, and it delivers the beta-lactam signal to VbrR to induce the transcription of the beta-lactamase gene. To determine the structural features of VbrK(SD) as the prototype of the PF11884 family and provide insights into the beta-lactam antibiotic-binding mode of VbrK(SD), we determined the crystal structure of VbrK(SD) at 1.65 A resolution. VbrK(SD) folds into a unique curved rod-like structure that has not been previously reported in other families. VbrK(SD) consists of two domains (D1 and D2). The D1 domain contains two helix-decorated beta-sheets, and the D2 domain adopts a helix-rich structure. VbrK(SD) features two terminal disulfide bonds, which would be the canonical property of the PF11884 family. In the VbrK(SD) structure, the L82 residue, which was previously shown to play a key role in beta-lactam antibiotic recognition, forms a pocket along with its neighboring hydrophobic or positively charged residues.

			Structural analysis of the sensor domain of the beta-lactam antibiotic receptor VbrK from Vibrio parahaemolyticus.,Cho SY, Yoon SI Biochem Biophys Res Commun. 2020 Sep 14. pii: S0006-291X(20)31747-2. doi:, 10.1016/j.bbrc.2020.09.011. PMID:32943185<ref>PMID:32943185</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7cus" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cho SY]]		[[Category: Cho, S Y]]
	[[Category: Yoon SI]]		[[Category: Yoon, S I]]
			[[Category: Beta-lactam antibiotic receptor]]
			[[Category: Sensor domain]]
			[[Category: Signaling protein]]

OCA at 06:22, 7 October 2020

2020-10-07T06:22:50Z

← Older revision		Revision as of 06:22, 7 October 2020
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7cus is ~~ON HOLD until Paper Publication~~		==Crystal structure of the sensor domain of VbrK from Vibrio parahaemolyticus==
			<StructureSection load='7cus' size='340' side='right'caption='[[7cus]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CUS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CUS FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7cus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cus OCA], [http://pdbe.org/7cus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7cus RCSB], [http://www.ebi.ac.uk/pdbsum/7cus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7cus ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Cho SY]]
			[[Category: Yoon SI]]

OCA: Protected "7cus" [edit=sysop:move=sysop]

2020-09-02T05:14:09Z

Protected "7cus" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:14, 2 September 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7cus is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2020-09-02T05:14:08Z

New page: '''Unreleased structure''' The entry 7cus is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7cus is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]