7dpy - Revision history

OCA at 16:37, 29 November 2023

2023-11-29T16:37:49Z

← Older revision		Revision as of 16:37, 29 November 2023
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	<StructureSection load='7dpy' size='340' side='right'caption='[[7dpy]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='7dpy' size='340' side='right'caption='[[7dpy]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7dpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bruab Bruab~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[7dpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_bv._1_str._9-941 Brucella abortus bv. 1 str. 9-941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DPY FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BruAb1_0102 (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info&srchmode=5~~&~~id=262698 BRUAB])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dpy OCA], [https://pdbe.org/7dpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dpy RCSB], [https://www.ebi.ac.uk/pdbsum/7dpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dpy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dpy OCA], [https://pdbe.org/7dpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dpy RCSB], [https://www.ebi.ac.uk/pdbsum/7dpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dpy ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q57FR6_BRUAB Q57FR6_BRUAB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bruab~~]]		[[Category: Brucella abortus bv. 1 str. 9-941]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ha, N C]]		[[Category: Ha N-C]]
	[[Category: Hyun, Y]]		[[Category: Hyun Y]]
	~~[[Category: Lysozyme inhibitor]]~~
	~~[[Category: Plic]]~~
	~~[[Category: T4ss]]~~
	~~[[Category: Unknown function~~]]

OCA at 06:16, 11 August 2021

2021-08-11T06:16:11Z

← Older revision		Revision as of 06:16, 11 August 2021
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	==Structure of Brucella abortus PhiA==		==Structure of Brucella abortus PhiA==
	<StructureSection load='7dpy' size='340' side='right'caption='[[7dpy]]' scene=''>		<StructureSection load='7dpy' size='340' side='right'caption='[[7dpy]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DPY FirstGlance]. <br>		<table><tr><td colspan='2'>[[7dpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bruab Bruab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DPY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dpy OCA], [https://pdbe.org/7dpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dpy RCSB], [https://www.ebi.ac.uk/pdbsum/7dpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dpy ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BruAb1_0102 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262698 BRUAB])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dpy OCA], [https://pdbe.org/7dpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dpy RCSB], [https://www.ebi.ac.uk/pdbsum/7dpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dpy ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A recent genetic study with Brucella abortus revealed the secretion activator gene A (SagA) as an autolysin component creating pores in the peptidoglycan (PGN) layer for the type IV secretion system (T4SS) and peptidoglycan hydrolase inhibitor A (PhiA) as an inhibitor of SagA. In this study, we determined the crystal structures of both SagA and PhiA. Notably, the SagA structure contained a PGN fragment in a space between the N- and C-terminal domains, showing the substrate-dependent hinge motion of the domains. The purified SagA fully hydrolyzed the meso-diaminopimelic acid (DAP)-type PGN, showing a higher activity than hen egg-white lysozyme. The PhiA protein exhibiting tetrameric assembly failed to inhibit SagA activity in our experiments. Our findings provide implications for the molecular basis of the SagA-PhiA system of B. abortus. The development of inhibitors of SagA would further contribute to controlling brucellosis by attenuating the function of T4SS, the major virulence factor of Brucella.

			Structure and Function of the Autolysin SagA in the Type IV Secretion System of Brucella abortus.,Hyun Y, Baek Y, Lee C, Ki N, Ahn J, Ryu S, Ha NC Mol Cells. 2021 Jun 11. pii: molcells.2021.0011. doi:, 10.14348/molcells.2021.0011. PMID:34112742<ref>PMID:34112742</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7dpy" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bruab]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ha N-C]]		[[Category: Ha, N C]]
	[[Category: Hyun Y]]		[[Category: Hyun, Y]]
			[[Category: Lysozyme inhibitor]]
			[[Category: Plic]]
			[[Category: T4ss]]
			[[Category: Unknown function]]

OCA at 07:30, 25 June 2021

2021-06-25T07:30:39Z

← Older revision		Revision as of 07:30, 25 June 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7dpy is ~~ON HOLD until Paper Publication~~		==Structure of Brucella abortus PhiA==
			<StructureSection load='7dpy' size='340' side='right'caption='[[7dpy]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DPY FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dpy OCA], [https://pdbe.org/7dpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dpy RCSB], [https://www.ebi.ac.uk/pdbsum/7dpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dpy ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Ha N-C]]
			[[Category: Hyun Y]]

OCA: Protected "7dpy" [edit=sysop:move=sysop]

2020-12-30T05:23:02Z

Protected "7dpy" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:23, 30 December 2020
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7dpy is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2020-12-30T05:23:01Z

New page: '''Unreleased structure''' The entry 7dpy is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7dpy is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]