OCA at 16:49, 29 November 2023

2023-11-29T16:49:23Z

← Older revision		Revision as of 16:49, 29 November 2023
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	====		==Crystal structure of TCR-017 ectodomain==
	<StructureSection load='7ea6' size='340' side='right'caption='[[7ea6]]' scene=''>		<StructureSection load='7ea6' size='340' side='right'caption='[[7ea6]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ea6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EA6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ea6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ea6 OCA], [https://pdbe.org/7ea6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ea6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ea6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ea6 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1800025Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ea6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ea6 OCA], [https://pdbe.org/7ea6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ea6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ea6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ea6 ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Adaptive immunity is a fundamental component in controlling COVID-19. In this process, follicular helper T (Tfh) cells are a subset of CD4+ T cells that mediate the production of protective antibodies; however, the SARS-CoV-2 epitopes activating Tfh cells are not well characterized. Here, we identified and crystallized TCRs of public circulating Tfh (cTfh) clonotypes that are expanded in patients who have recovered from mild symptoms. These public clonotypes recognized the SARS-CoV-2 spike (S) epitopes conserved across emerging variants. The epitope of the most prevalent cTfh clonotype, S864-882, was presented by multiple HLAs and activated T cells in most healthy donors, suggesting that this S region is a universal T cell epitope useful for booster antigen. SARS-CoV-2-specific public cTfh clonotypes also cross-reacted with specific commensal bacteria. In this study, we identified conserved SARS-CoV-2 S epitopes that activate public cTfh clonotypes associated with mild symptoms.

			Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.,Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S J Exp Med. 2021 Dec 6;218(12):e20211327. doi: 10.1084/jem.20211327. Epub 2021 Oct , 14. PMID:34647971<ref>PMID:34647971</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7ea6" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Nagae M]]
			[[Category: Yamasaki S]]

OCA at 11:40, 13 October 2021

2021-10-13T11:40:55Z

← Older revision		Revision as of 11:40, 13 October 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7ea6 is ~~ON HOLD~~		====
			<StructureSection load='7ea6' size='340' side='right'caption='[[7ea6]]' scene=''>
	~~Authors:~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ea6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ea6 OCA], [https://pdbe.org/7ea6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ea6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ea6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ea6 ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA: Protected "7ea6" [edit=sysop:move=sysop]

2021-03-17T05:16:57Z

Protected "7ea6" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:16, 17 March 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7ea6 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-03-17T05:16:55Z

New page: '''Unreleased structure''' The entry 7ea6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ea6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ea6 - Revision history

OCA at 16:49, 29 November 2023

OCA at 11:40, 13 October 2021

OCA: Protected "7ea6" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ea6 is ON HOLD Authors: Description: Category: Unreleased Structures