OCA at 16:49, 29 November 2023

2023-11-29T16:49:23Z

← Older revision		Revision as of 16:49, 29 November 2023
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	====		==crystal structure of NAP1 LIR in complex with GABARAP==
	<StructureSection load='7ea7' size='340' side='right'caption='[[7ea7]]' scene=''>		<StructureSection load='7ea7' size='340' side='right'caption='[[7ea7]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ea7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EA7 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ea7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ea7 OCA], [https://pdbe.org/7ea7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ea7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ea7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ea7 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.69Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ea7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ea7 OCA], [https://pdbe.org/7ea7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ea7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ea7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ea7 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The recruitment of Unc-51-like kinase and TANK-binding kinase 1 complexes is essential for Nuclear dot protein 52-mediated selective autophagy and relies on the specific association of NDP52, RB1-inducible coiled-coil protein 1, and Nak-associated protein 1 (5-azacytidine-induced protein 2, AZI2). However, the underlying molecular mechanism remains elusive. Here, we find that except for the NDP52 SKIP carboxyl homology (SKICH)/RB1CC1 coiled-coil interaction, the LC3-interacting region of NDP52 can directly interact with the RB1CC1 Claw domain, as that of NAP1 FIP200-binding region (FIR). The determined crystal structures of NDP52 SKICH/RB1CC1 complex, NAP1 FIR/RB1CC1 complex, and the related NAP1 FIR/Gamma-aminobutyric acid receptor-associated protein complex not only elucidate the molecular bases underpinning the interactions of RB1CC1 with NDP52 and NAP1 but also reveal that RB1CC1 Claw and Autophagy-related protein 8 family proteins are competitive in binding to NAP1 and NDP52. Overall, our findings provide mechanistic insights into the interactions of NDP52, NAP1 with RB1CC1 and ATG8 family proteins.

			Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52.,Fu T, Zhang M, Zhou Z, Wu P, Peng C, Wang Y, Gong X, Li Y, Wang Y, Xu X, Li M, Shen L, Pan L Sci Adv. 2021 Aug 13;7(33). pii: 7/33/eabi6582. doi: 10.1126/sciadv.abi6582., Print 2021 Aug. PMID:34389544<ref>PMID:34389544</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7ea7" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Fu T]]
			[[Category: Pan L]]

OCA at 15:25, 22 December 2021

2021-12-22T15:25:06Z

← Older revision		Revision as of 15:25, 22 December 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7ea7 is ~~ON HOLD~~		====
			<StructureSection load='7ea7' size='340' side='right'caption='[[7ea7]]' scene=''>
	~~Authors~~: Fu, T., ~~Pan~~, L.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~: ~~crystal structure of NAP1 LIR in complex with GABARAP~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ea7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ea7 OCA], [https://pdbe.org/7ea7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ea7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ea7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ea7 ProSAT]</span></td></tr>
	[~~[Category~~: ~~Unreleased Structures]~~]		</table>
	[[Category: ~~Pan, L~~]]		__TOC__
	[[Category: ~~Fu, T~~]]		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA: Protected "7ea7" [edit=sysop:move=sysop]

2021-03-17T05:16:59Z

Protected "7ea7" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:16, 17 March 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7ea7 is ON HOLD Authors: Fu, T., Pan, L. Description: crystal structure of NAP1 LIR in complex with GABARAP Category: Unreleased Structures [[C...

2021-03-17T05:16:58Z

New page: '''Unreleased structure''' The entry 7ea7 is ON HOLD Authors: Fu, T., Pan, L. Description: crystal structure of NAP1 LIR in complex with GABARAP Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 7ea7 is ON HOLD

Authors: Fu, T., Pan, L.

Description: crystal structure of NAP1 LIR in complex with GABARAP
[[Category: Unreleased Structures]]
[[Category: Pan, L]]
[[Category: Fu, T]]

7ea7 - Revision history

OCA at 16:49, 29 November 2023

OCA at 15:25, 22 December 2021

OCA: Protected "7ea7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ea7 is ON HOLD Authors: Fu, T., Pan, L. Description: crystal structure of NAP1 LIR in complex with GABARAP Category: Unreleased Structures [[C...