7ejs - Revision history

OCA at 16:55, 29 November 2023

2023-11-29T16:55:23Z

← Older revision		Revision as of 16:55, 29 November 2023
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	<StructureSection load='7ejs' size='340' side='right'caption='[[7ejs]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='7ejs' size='340' side='right'caption='[[7ejs]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ejs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ejs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJS FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~pid~~-3, ~~pics-1, Y23H5A.3 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=6239 CAEEL])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.387Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ejs OCA], [https://pdbe.org/7ejs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ejs RCSB], [https://www.ebi.ac.uk/pdbsum/7ejs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ejs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ejs OCA], [https://pdbe.org/7ejs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ejs RCSB], [https://www.ebi.ac.uk/pdbsum/7ejs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ejs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ERH2_CAEEL ERH2_CAEEL]] Required for chromosome segregation and cell division in early embryos (PubMed:31216475). Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing (PubMed:31147388). Promotes the biogenesis of 21U-RNAs (PubMed:31216475).<ref>PMID:31147388</ref> <ref>PMID:31216475</ref> <ref>PMID:31216475</ref>		[https://www.uniprot.org/uniprot/PID3_CAEEL PID3_CAEEL] Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the pid-1 variant of the PETISCO complex may stabilize 21U-RNA precursor molecules (PubMed:31147388). Promotes the biogenesis of 21U-RNAs (PubMed:31216475). Required for chromosome segregation and cell division in early embryos (PubMed:31216475).<ref>PMID:31147388</ref> <ref>PMID:31216475</ref> <ref>PMID:31216475</ref> [https://www.uniprot.org/uniprot/ERH2_CAEEL ERH2_CAEEL] Required for chromosome segregation and cell division in early embryos (PubMed:31216475). Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing (PubMed:31147388). Promotes the biogenesis of 21U-RNAs (PubMed:31216475).<ref>PMID:31147388</ref> <ref>PMID:31216475</ref> <ref>PMID:31216475</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Caeel~~]]		[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Wang, X]]		[[Category: Wang X]]
	[[Category: Xu, C]]		[[Category: Xu C]]
	~~[[Category: Peptide binding protein]]~~
	~~[[Category: Pics complex~~]]

OCA at 05:52, 6 October 2021

2021-10-06T05:52:51Z

← Older revision		Revision as of 05:52, 6 October 2021
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	==Structure of ERH-2 bound to PICS-1==		==Structure of ERH-2 bound to PICS-1==
	<StructureSection load='7ejs' size='340' side='right'caption='[[7ejs]]' scene=''>		<StructureSection load='7ejs' size='340' side='right'caption='[[7ejs]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ejs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ejs OCA], [https://pdbe.org/7ejs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ejs RCSB], [https://www.ebi.ac.uk/pdbsum/7ejs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ejs ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pid-3, pics-1, Y23H5A.3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ejs OCA], [https://pdbe.org/7ejs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ejs RCSB], [https://www.ebi.ac.uk/pdbsum/7ejs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ejs ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/ERH2_CAEEL ERH2_CAEEL]] Required for chromosome segregation and cell division in early embryos (PubMed:31216475). Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing (PubMed:31147388). Promotes the biogenesis of 21U-RNAs (PubMed:31216475).<ref>PMID:31147388</ref> <ref>PMID:31216475</ref> <ref>PMID:31216475</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			By incorporating two mutually exclusive factors, PID-1 and TOST-1, C. elegans PICS complex plays important roles in piRNA biogenesis, chromosome segregation and cell division. We firstly map the interaction network between PICS subunits, then uncover the mechanisms underlying the interactions between PICS subunits by solving several complex structures, including those of TOFU-6/PICS-1, ERH-2/PICS-1, and ERH-2/TOST-1. Our biochemical experiment also demonstrates that PICS exists as an octamer consisting of two copies of each subunit. Combining structural analyses with mutagenesis experiments, we identify interfacial residues of PICS subunits that are critical for maintaining intact PICS complex in vitro. Furthermore, using genetics, cell biology and imaging experiments, we find that those mutants impairing the in vitro interaction network within PICS, also lead to dysfunction of PICS in vivo, including mislocalization of PICS, and reduced levels of piRNAs or aberrant chromosome segregation and cell division. Therefore, our work provides structural insights into understanding the PICS-mediated piRNA biogenesis and cell division.

			Molecular basis for PICS-mediated piRNA biogenesis and cell division.,Wang X, Zeng C, Liao S, Zhu Z, Zhang J, Tu X, Yao X, Feng X, Guang S, Xu C Nat Commun. 2021 Sep 22;12(1):5595. doi: 10.1038/s41467-021-25896-7. PMID:34552083<ref>PMID:34552083</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7ejs" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Caeel]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Wang X]]		[[Category: Wang, X]]
	[[Category: Xu C]]		[[Category: Xu, C]]
			[[Category: Peptide binding protein]]
			[[Category: Pics complex]]

OCA at 06:18, 25 August 2021

2021-08-25T06:18:40Z

← Older revision		Revision as of 06:18, 25 August 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7ejs is ~~ON HOLD until Apr 02 2023~~		==Structure of ERH-2 bound to PICS-1==
			<StructureSection load='7ejs' size='340' side='right'caption='[[7ejs]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJS FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ejs OCA], [https://pdbe.org/7ejs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ejs RCSB], [https://www.ebi.ac.uk/pdbsum/7ejs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ejs ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Wang X]]
			[[Category: Xu C]]

OCA at 08:40, 19 May 2021

2021-05-19T08:40:02Z

← Older revision		Revision as of 08:40, 19 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7ejs is ON HOLD		The entry 7ejs is ON HOLD until Apr 02 2023

	Authors:		Authors:

OCA: Protected "7ejs" [edit=sysop:move=sysop]

2021-04-07T04:34:10Z

Protected "7ejs" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:34, 7 April 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7ejs is ON HOLD Authors: Description: Category: Unreleased Structures

2021-04-07T04:34:10Z

New page: '''Unreleased structure''' The entry 7ejs is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ejs is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]