7emo - Revision history

OCA at 14:12, 13 August 2026

2026-08-13T14:12:49Z

← Older revision		Revision as of 14:12, 13 August 2026
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	<StructureSection load='7emo' size='340' side='right'caption='[[7emo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='7emo' size='340' side='right'caption='[[7emo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[7emo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	~~[https://www.uniprot.org/uniprot/G3XD33_PSEAE G3XD33_PSEAE]~~
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene.

	Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.,Shisaka Y, Sakakibara E, Suzuki K, Stanfield JK, Onoda H, Ueda G, Hatano M, Sugimoto H, Shoji O Chembiochem. 2022 Jul 19;23(14):e202200095. doi: 10.1002/cbic.202200095. Epub, 2022 Apr 13. PMID:35352458<ref>PMID:35352458</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 7emo" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Pseudomonas aeruginosa PAO1]]~~
	[[Category: Shisaka Y]]		[[Category: Shisaka Y]]
	[[Category: Shoji O]]		[[Category: Shoji O]]
	[[Category: Sugimoto H]]		[[Category: Sugimoto H]]

OCA at 16:56, 29 November 2023

2023-11-29T16:56:46Z

← Older revision		Revision as of 16:56, 29 November 2023
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	<StructureSection load='7emo' size='340' side='right'caption='[[7emo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='7emo' size='340' side='right'caption='[[7emo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7emo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[7emo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/G3XD33_PSEAE G3XD33_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Shisaka, Y~~]]		[[Category: Pseudomonas aeruginosa PAO1]]
	[[Category: ~~Shoji, O~~]]		[[Category: Shisaka Y]]
	[[Category: ~~Sugimoto, H~~]]		[[Category: Shoji O]]
	[[Category: ~~Heme acquisition protein]]~~		[[Category: Sugimoto H]]
	~~[[Category: Transport protein~~]]

OCA at 06:31, 18 August 2022

2022-08-18T06:31:32Z

← Older revision		Revision as of 06:31, 18 August 2022
Line 1:		Line 1:

	==Crystal Structure of HasAp Capturing Iron Tetraphenylporphyrin==		==Crystal Structure of HasAp Capturing Iron Tetraphenylporphyrin==
	<StructureSection load='7emo' size='340' side='right'caption='[[7emo]]' scene=''>		<StructureSection load='7emo' size='340' side='right'caption='[[7emo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[7emo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene.

			Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.,Shisaka Y, Sakakibara E, Suzuki K, Stanfield JK, Onoda H, Ueda G, Hatano M, Sugimoto H, Shoji O Chembiochem. 2022 Jul 19;23(14):e202200095. doi: 10.1002/cbic.202200095. Epub, 2022 Apr 13. PMID:35352458<ref>PMID:35352458</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7emo" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Shisaka Y]]		[[Category: Shisaka, Y]]
	[[Category: Shoji O]]		[[Category: Shoji, O]]
	[[Category: Sugimoto H]]		[[Category: Sugimoto, H]]
			[[Category: Heme acquisition protein]]
			[[Category: Transport protein]]

OCA at 02:49, 21 April 2022

2022-04-21T02:49:26Z

← Older revision		Revision as of 02:49, 21 April 2022
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 7emo is ~~ON HOLD until Paper Publication~~		==Crystal Structure of HasAp Capturing Iron Tetraphenylporphyrin==
			<StructureSection load='7emo' size='340' side='right'caption='[[7emo]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMO FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emo OCA], [https://pdbe.org/7emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emo RCSB], [https://www.ebi.ac.uk/pdbsum/7emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emo ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Shisaka Y]]
			[[Category: Shoji O]]
			[[Category: Sugimoto H]]

OCA at 15:27, 15 December 2021

2021-12-15T15:27:19Z

← Older revision		Revision as of 15:27, 15 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7emo is ON HOLD		The entry 7emo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7emo" [edit=sysop:move=sysop]

2021-04-21T06:08:26Z

Protected "7emo" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:08, 21 April 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7emo is ON HOLD Authors: Description: Category: Unreleased Structures

2021-04-21T06:08:25Z

New page: '''Unreleased structure''' The entry 7emo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7emo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]