7env - Revision history

OCA at 16:57, 29 November 2023

2023-11-29T16:57:23Z

← Older revision		Revision as of 16:57, 29 November 2023
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	<StructureSection load='7env' size='340' side='right'caption='[[7env]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='7env' size='340' side='right'caption='[[7env]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7env]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ENV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ENV FirstGlance]. <br>		<table><tr><td colspan='2'>[[7env]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ENV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ENV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUX:7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione'>BUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUX:7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione'>BUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7env FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7env OCA], [https://pdbe.org/7env PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7env RCSB], [https://www.ebi.ac.uk/pdbsum/7env PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7env ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7env FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7env OCA], [https://pdbe.org/7env PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7env RCSB], [https://www.ebi.ac.uk/pdbsum/7env PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7env ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>		[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7env" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7env" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arole, A]]		[[Category: Arole A]]
	[[Category: Ashok, S]]		[[Category: Ashok S]]
	[[Category: Deshmukh, P]]		[[Category: Deshmukh P]]
	[[Category: Padmanabhan, B]]		[[Category: Padmanabhan B]]
	~~[[Category: Bet family]]~~
	~~[[Category: Bet inhibitor]]~~
	~~[[Category: Brd2-bd1 inhibitor]]~~
	~~[[Category: Bromodomain inhibitor]]~~
	~~[[Category: Transcription-inhibitor complex~~]]

OCA at 07:14, 16 March 2022

2022-03-16T07:14:36Z

← Older revision		Revision as of 07:14, 16 March 2022
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	==crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2 (BRD2-BD1).==		==crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2 (BRD2-BD1).==
	<StructureSection load='7env' size='340' side='right'caption='[[7env]]' scene=''>		<StructureSection load='7env' size='340' side='right'caption='[[7env]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ENV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ENV FirstGlance]. <br>		<table><tr><td colspan='2'>[[7env]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ENV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ENV FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7env FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7env OCA], [https://pdbe.org/7env PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7env RCSB], [https://www.ebi.ac.uk/pdbsum/7env PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7env ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUX:7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione'>BUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7env FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7env OCA], [https://pdbe.org/7env PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7env RCSB], [https://www.ebi.ac.uk/pdbsum/7env PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7env ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The BET (bromodomain and extra-terminal) family of proteins recognize the acetylated histone code on chromatin and play important roles in transcriptional co-regulation. BRD2 and BRD4, which belong to the BET family, are promising drug targets for the management of chronic diseases. The discovery of new scaffold molecules, a pyrano-1,3-oxazine derivative (NSC 328111; NS5) and phenanthridinone-based derivatives (L10 and its core moiety L10a), as inhibitors of BRD2 bromodomains BD1 and BD2, respectively, has recently been reported. The compound NS5 has a significant inhibitory effect on BRD2 in glioblastoma. Here, the crystal structure of BRD2 BD2 in complex with NS5, refined to 2.0 A resolution, is reported. Moreover, as the previously reported crystal structures of the BD1-NS5 complex and the BD2-L10a complex possess moderate electron density corresponding to the respective ligands, the crystal structures of these complexes were re-evaluated using new X-ray data. Together with biochemical studies using wild-type BRD2 BD1 and BD2 and various mutants, it is confirmed that the pyrano-1,3-oxazine and phenanthridinone derivatives are indeed potent inhibitors of BRD2 bromodomains.

			Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains.,Arole AH, Deshmukh P, Sridhar A, Padmanabhan B Acta Crystallogr F Struct Biol Commun. 2022 Mar 1;78(Pt 3):119-127. doi:, 10.1107/S2053230X22001066. Epub 2022 Feb 23. PMID:35234137<ref>PMID:35234137</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7env" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arole A]]		[[Category: Arole, A]]
	[[Category: Ashok S]]		[[Category: Ashok, S]]
	[[Category: Deshmukh P]]		[[Category: Deshmukh, P]]
	[[Category: Padmanabhan B]]		[[Category: Padmanabhan, B]]
			[[Category: Bet family]]
			[[Category: Bet inhibitor]]
			[[Category: Brd2-bd1 inhibitor]]
			[[Category: Bromodomain inhibitor]]
			[[Category: Transcription-inhibitor complex]]

OCA at 06:04, 9 March 2022

2022-03-09T06:04:58Z

← Older revision		Revision as of 06:04, 9 March 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7env is ~~ON HOLD until Apr 19 2023~~		==crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2 (BRD2-BD1).==
			<StructureSection load='7env' size='340' side='right'caption='[[7env]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ENV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ENV FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7env FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7env OCA], [https://pdbe.org/7env PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7env RCSB], [https://www.ebi.ac.uk/pdbsum/7env PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7env ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Arole A]]
			[[Category: Ashok S]]
			[[Category: Deshmukh P]]
			[[Category: Padmanabhan B]]

OCA at 06:01, 25 June 2021

2021-06-25T06:01:56Z

← Older revision		Revision as of 06:01, 25 June 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7env is ON HOLD		The entry 7env is ON HOLD until Apr 19 2023

	Authors:		Authors:

OCA: Protected "7env" [edit=sysop:move=sysop]

2021-04-28T04:12:31Z

Protected "7env" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:12, 28 April 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7env is ON HOLD Authors: Description: Category: Unreleased Structures

2021-04-28T04:12:31Z

New page: '''Unreleased structure''' The entry 7env is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7env is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]