OCA at 11:00, 23 October 2024

2024-10-23T11:00:22Z

← Older revision		Revision as of 11:00, 23 October 2024
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	====		==Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901 bound state==
	<StructureSection load='7eor' size='340' side='right'caption='[[7eor]]' scene=''>		<StructureSection load='7eor' size='340' side='right'caption='[[7eor]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7eor]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EOR FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eor OCA], [https://pdbe.org/7eor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eor RCSB], [https://www.ebi.ac.uk/pdbsum/7eor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eor ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RM:7-[(4-FLUORANYLPHENOXY)METHYL]-3-[(1~{R},2~{R})-2-(HYDROXYMETHYL)CYCLOPROPYL]-2-METHYL-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE'>6RM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eor OCA], [https://pdbe.org/7eor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eor RCSB], [https://www.ebi.ac.uk/pdbsum/7eor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eor ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2). GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			N-methyl-D-aspartate (NMDA) receptors are glutamate-gated calcium-permeable ion channels that are widely implicated in synaptic transmission and plasticity. Here, we report a gallery of cryo-electron microscopy (cryo-EM) structures of the human GluN1-GluN2A NMDA receptor at an overall resolution of 4 A in complex with distinct ligands or modulators. In the full-length context of GluN1-GluN2A receptors, we visualize the competitive antagonists bound to the ligand-binding domains (LBDs) of GluN1 and GluN2A subunits, respectively. We reveal that the binding of positive allosteric modulator shortens the distance between LBDs and the transmembrane domain (TMD), which further stretches the opening of the gate. In addition, we unexpectedly visualize the binding cavity of the "foot-in-the-door" blocker 9-aminoacridine within the LBD-TMD linker region, differing from the conventional "trapping" blocker binding site at the vestibule within the TMD. Our study provides molecular insights into the crosstalk between LBDs and TMD during channel activation, inhibition, and allosteric transition.

			Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors.,Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S Neuron. 2021 Aug 4;109(15):2443-2456.e5. doi: 10.1016/j.neuron.2021.05.031. Epub , 2021 Jun 28. PMID:34186027<ref>PMID:34186027</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7eor" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Wang H]]
			[[Category: Zhu S]]

OCA at 03:33, 2 July 2021

2021-07-02T03:33:32Z

← Older revision		Revision as of 03:33, 2 July 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7eor is ~~ON HOLD until Paper Publication~~		====
			<StructureSection load='7eor' size='340' side='right'caption='[[7eor]]' scene=''>
	~~Authors:~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eor OCA], [https://pdbe.org/7eor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eor RCSB], [https://www.ebi.ac.uk/pdbsum/7eor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eor ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA at 08:40, 19 May 2021

2021-05-19T08:40:56Z

← Older revision		Revision as of 08:40, 19 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7eor is ON HOLD		The entry 7eor is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7eor" [edit=sysop:move=sysop]

2021-04-28T04:13:49Z

Protected "7eor" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:13, 28 April 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7eor is ON HOLD Authors: Description: Category: Unreleased Structures

2021-04-28T04:13:48Z

New page: '''Unreleased structure''' The entry 7eor is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7eor is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7eor - Revision history

OCA at 11:00, 23 October 2024

OCA at 03:33, 2 July 2021

OCA at 08:40, 19 May 2021

OCA: Protected "7eor" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7eor is ON HOLD Authors: Description: Category: Unreleased Structures