7g86 - Revision history

OCA at 10:34, 22 May 2024

2024-05-22T10:34:29Z

← Older revision		Revision as of 10:34, 22 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>		[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>

			==See Also==
			*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:06, 12 July 2023

2023-07-12T07:06:08Z

← Older revision		Revision as of 07:06, 12 July 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7g86 is ~~ON HOLD~~		==ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1137725943==
			<StructureSection load='7g86' size='340' side='right'caption='[[7g86]], [[Resolution\|resolution]] 1.70Å' scene=''>
	~~Authors~~: ~~Bradshaw~~, W.J., ~~Katis, V~~.L., ~~Bountra~~, C., ~~von Delft, F~~., ~~Brennan, P~~.E.		== Structural highlights ==
			<table><tr><td colspan='2'>[[7g86]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G86 FirstGlance]. <br>
	~~Description~~: ~~ARHGEF2 PanDDA analysis group deposition~~ --ARHGEF2 and ~~RhoA~~ in ~~complex with Z1137725943~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.699Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=YXB:N-[(1H-indol-4-yl)methyl]ethanamine'>YXB</scene></td></tr>
	[[Category: ~~Katis, V.L~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g86 OCA], [https://pdbe.org/7g86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g86 RCSB], [https://www.ebi.ac.uk/pdbsum/7g86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g86 ProSAT]</span></td></tr>
	[[Category: ~~Von Delft, F~~]]		</table>
	[[Category: ~~Bountra, C~~]]		== Function ==
	[[Category: ~~Brennan, P.E~~]]		[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
	[[Category: ~~Bradshaw, W.J~~]]		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Bountra C]]
			[[Category: Bradshaw WJ]]
			[[Category: Brennan PE]]
			[[Category: Katis VL]]
			[[Category: Von Delft F]]

OCA: Protected "7g86" [edit=sysop:move=sysop]

2023-06-28T19:31:10Z

Protected "7g86" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:31, 28 June 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7g86 is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E. Description: ARHGEF2 PanDDA analysis group depositi...

2023-06-28T19:31:08Z

New page: '''Unreleased structure''' The entry 7g86 is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E. Description: ARHGEF2 PanDDA analysis group depositi...

New page

'''Unreleased structure'''

The entry 7g86 is ON HOLD

Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E.

Description: ARHGEF2 PanDDA analysis group deposition --ARHGEF2 and RhoA in complex with Z1137725943
[[Category: Unreleased Structures]]
[[Category: Katis, V.L]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]
[[Category: Brennan, P.E]]
[[Category: Bradshaw, W.J]]