7lib - Revision history

OCA at 10:59, 15 November 2023

2023-11-15T10:59:51Z

← Older revision		Revision as of 10:59, 15 November 2023
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	<StructureSection load='7lib' size='340' side='right'caption='[[7lib]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='7lib' size='340' side='right'caption='[[7lib]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7lib]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7lib]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIB FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene>, <scene name='pdbligand=Y1V:'>Y1V</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene>, <scene name='pdbligand=Y1V:(4R)-5-amino-L-leucine'>Y1V</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lib OCA], [https://pdbe.org/7lib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lib RCSB], [https://www.ebi.ac.uk/pdbsum/7lib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lib ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lib OCA], [https://pdbe.org/7lib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lib RCSB], [https://www.ebi.ac.uk/pdbsum/7lib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lib ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Li, X~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Nowick, J S~~]]		[[Category: Li X]]
	[[Category: ~~Wierzbicki, M~~]]		[[Category: Nowick JS]]
	[[Category: ~~Beta-2-microglobulin]]~~		[[Category: Wierzbicki M]]
	~~[[Category: De novo protein]]~~
	~~[[Category: Turn unit~~]]

OCA at 20:14, 20 October 2021

2021-10-20T20:14:46Z

← Older revision		Revision as of 20:14, 20 October 2021
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	==X-ray crystal structure of a cyclic peptide containing beta-2-microglobulin (63-69) and a gamma-methylornithine turn unit==		==X-ray crystal structure of a cyclic peptide containing beta-2-microglobulin (63-69) and a gamma-methylornithine turn unit==
	<StructureSection load='7lib' size='340' side='right'caption='[[7lib]]' scene=''>		<StructureSection load='7lib' size='340' side='right'caption='[[7lib]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7lib]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lib OCA], [https://pdbe.org/7lib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lib RCSB], [https://www.ebi.ac.uk/pdbsum/7lib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lib ProSAT]</span></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene>, <scene name='pdbligand=Y1V:'>Y1V</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lib OCA], [https://pdbe.org/7lib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lib RCSB], [https://www.ebi.ac.uk/pdbsum/7lib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lib ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Although beta-hairpins are widespread in proteins, there is still no universal tool to coax any small peptide to adopt a beta-hairpin conformation, regardless of sequence. Here, we report that delta-linked gamma( R )-methyl-ornithine ( delta MeOrn) provides an improved beta-turn template for inducing a beta-hairpin conformation in peptides. We have developed a synthesis of protected delta MeOrn as a building block suitable for use in Fmoc-based solid-phase peptide synthesis. The synthesis begins with l -leucine and affords gram quantities of the N alpha -Boc- N delta -Fmoc-gamma( R )-methyl-ornithine building block. X-ray crystallography confirms that the delta MeOrn turn unit adopts a folded structure in a macrocyclic beta-hairpin peptide. CD and NMR spectroscopic experiments allow comparison of the delta MeOrn turn template to the delta-linked ornithine ( delta Orn) turn template that our laboratory has previously introduced and also to the popular d -Pro-Gly turn template. Collectively, these studies demonstrate that the folding of the delta MeOrn turn template is substantially better than that of delta Orn and is comparable to d -Pro-Gly.

			An Improved Turn Structure for Inducing beta-Hairpin Formation in Peptides.,Nowick JS, Li X, Sabol AL, Wierzbicki M, Salveson PJ Angew Chem Int Ed Engl. 2021 Jul 13. doi: 10.1002/anie.202105559. PMID:34258835<ref>PMID:34258835</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7lib" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li X]]		[[Category: Li, X]]
	[[Category: Nowick JS]]		[[Category: Nowick, J S]]
	[[Category: Wierzbicki M]]		[[Category: Wierzbicki, M]]
			[[Category: Beta-2-microglobulin]]
			[[Category: De novo protein]]
			[[Category: Turn unit]]

OCA at 06:07, 11 August 2021

2021-08-11T06:07:16Z

← Older revision		Revision as of 06:07, 11 August 2021
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	~~'''Unreleased structure'''~~

	~~The entry 7lib is ON HOLD until Paper Publication~~		==X-ray crystal structure of a cyclic peptide containing beta-2-microglobulin (63-69) and a gamma-methylornithine turn unit==
			<StructureSection load='7lib' size='340' side='right'caption='[[7lib]]' scene=''>
	~~Authors: Wierzbicki, M., Nowick, J.S., Li, X.~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIB FirstGlance]. <br>
	~~Description:~~ X-ray crystal structure of a cyclic peptide containing beta-2-microglobulin (63-69) and a gamma-methylornithine turn unit		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lib OCA], [https://pdbe.org/7lib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lib RCSB], [https://www.ebi.ac.uk/pdbsum/7lib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lib ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Wierzbicki, M~~]]		__TOC__
	[[Category: Nowick~~, J.S~~]]		</StructureSection>
	[[Category: ~~Li, X~~]]		[[Category: Large Structures]]
			[[Category: Li X]]
			[[Category: Nowick JS]]
			[[Category: Wierzbicki M]]

OCA at 08:44, 17 February 2021

2021-02-17T08:44:08Z

← Older revision		Revision as of 08:44, 17 February 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7lib is ON HOLD		The entry 7lib is ON HOLD until Paper Publication

	Authors: Wierzbicki, M., Nowick, J.S., Li, X.		Authors: Wierzbicki, M., Nowick, J.S., Li, X.

OCA: Protected "7lib" [edit=sysop:move=sysop]

2021-02-03T09:30:58Z

Protected "7lib" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:30, 3 February 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7lib is ON HOLD Authors: Wierzbicki, M., Nowick, J.S., Li, X. Description: X-ray crystal structure of a cyclic peptide containing beta-2-microglobu...

2021-02-03T09:30:57Z

New page: '''Unreleased structure''' The entry 7lib is ON HOLD Authors: Wierzbicki, M., Nowick, J.S., Li, X. Description: X-ray crystal structure of a cyclic peptide containing beta-2-microglobu...

New page

'''Unreleased structure'''

The entry 7lib is ON HOLD

Authors: Wierzbicki, M., Nowick, J.S., Li, X.

Description: X-ray crystal structure of a cyclic peptide containing beta-2-microglobulin (63-69) and a gamma-methylornithine turn unit
[[Category: Unreleased Structures]]
[[Category: Wierzbicki, M]]
[[Category: Nowick, J.S]]
[[Category: Li, X]]