7o7a - Revision history

OCA at 12:46, 1 February 2024

2024-02-01T12:46:01Z

← Older revision		Revision as of 12:46, 1 February 2024
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	<StructureSection load='7o7a' size='340' side='right'caption='[[7o7a]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='7o7a' size='340' side='right'caption='[[7o7a]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7o7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Psesl Psesl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[7o7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudopedobacter_saltans_DSM_12145 Pseudopedobacter saltans DSM 12145]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O7A FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Pedsa_0632 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=762903 PSESL])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o7a OCA], [https://pdbe.org/7o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o7a RCSB], [https://www.ebi.ac.uk/pdbsum/7o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o7a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o7a OCA], [https://pdbe.org/7o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o7a RCSB], [https://www.ebi.ac.uk/pdbsum/7o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o7a ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/F0S7Y7_PSESL F0S7Y7_PSESL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Psesl~~]]		[[Category: Pseudopedobacter saltans DSM 12145]]
	[[Category: Aghajari, N]]		[[Category: Aghajari N]]
	[[Category: Ballut, L]]		[[Category: Ballut L]]
	[[Category: Carrique, L]]		[[Category: Carrique L]]
	[[Category: Violot, S]]		[[Category: Violot S]]
	~~[[Category: Beta helix]]~~
	~~[[Category: Lyase~~]]

OCA at 14:17, 29 December 2021

2021-12-29T14:17:43Z

← Older revision		Revision as of 14:17, 29 December 2021
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	==Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans==		==Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans==
	<StructureSection load='7o7a' size='340' side='right'caption='[[7o7a]]' scene=''>		<StructureSection load='7o7a' size='340' side='right'caption='[[7o7a]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[7o7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Psesl Psesl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O7A FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o7a OCA], [https://pdbe.org/7o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o7a RCSB], [https://www.ebi.ac.uk/pdbsum/7o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o7a ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pedsa_0632 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=762903 PSESL])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o7a OCA], [https://pdbe.org/7o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o7a RCSB], [https://www.ebi.ac.uk/pdbsum/7o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o7a ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Polysaccharide Lyase Family 6 (PL6) represents one of the 41 polysaccharide lyase families classified in the CAZy database with the vast majority of its members being alginate lyases grouped into three subfamilies, PL6_1-3. To decipher the mode of recognition and action of the enzymes belonging to subfamily PL6_1, we solved the crystal structures of Pedsa0632, Patl3640, Pedsa3628 and Pedsa3807, which all show different substrate specificities and mode of action (endo-/exo-lyase). Thorough exploration of the structures of Pedsa0632 and Patl3640 in complex with their substrates as well as docking experiments confirm that the conserved residues in subsites -1 to +3 of the catalytic site form a common platform which can accommodate various types of alginate in a very similar manner but with a series of original adaptations bringing them their specificities of action. From comparative studies with existing structures of PL6_1 alginate lyases, we observe that in the right-handed parallel beta-helix fold shared by all these enzymes, the substrate binding site harbors the same overall conserved structures and organization. Despite this apparent similarity, it appears that members of the PL6_1 subfamily specifically accommodate and catalyze the degradation of different alginates suggesting that this common platform is actually a highly adaptable and specific tool.

			Exploring molecular determinants of polysaccharide Lyase family 6-1 enzyme activity.,Violot S, Galisson F, Carrique L, Jugnarain V, Conchou L, Robert X, Thureau A, Helbert W, Aghajari N, Ballut L Glycobiology. 2021 Jul 10. pii: 6318796. doi: 10.1093/glycob/cwab073. PMID:34245266<ref>PMID:34245266</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7o7a" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Aghajari N]]		[[Category: Psesl]]
	[[Category: Ballut L]]		[[Category: Aghajari, N]]
	[[Category: Carrique L]]		[[Category: Ballut, L]]
	[[Category: Violot S]]		[[Category: Carrique, L]]
			[[Category: Violot, S]]
			[[Category: Beta helix]]
			[[Category: Lyase]]

OCA at 10:35, 28 July 2021

2021-07-28T10:35:44Z

← Older revision		Revision as of 10:35, 28 July 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7o7a is ~~ON HOLD until Paper Publication~~		==Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans==
			<StructureSection load='7o7a' size='340' side='right'caption='[[7o7a]]' scene=''>
	~~Authors~~: ~~Ballut~~, L., ~~Violot~~, S., ~~Carrique~~, L.~~, Aghajari, N~~.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O7A FirstGlance]. <br>
	~~Description: Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o7a OCA], [https://pdbe.org/7o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o7a RCSB], [https://www.ebi.ac.uk/pdbsum/7o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o7a ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Carrique, L~~]]		__TOC__
	[[Category: ~~Violot, S~~]]		</StructureSection>
	[[Category: ~~Aghajari, N~~]]		[[Category: Large Structures]]
	[[Category: ~~Ballut, L~~]]		[[Category: Aghajari N]]
			[[Category: Ballut L]]
			[[Category: Carrique L]]
			[[Category: Violot S]]

OCA at 08:20, 12 May 2021

2021-05-12T08:20:28Z

← Older revision		Revision as of 08:20, 12 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7o7a is ON HOLD		The entry 7o7a is ON HOLD until Paper Publication

	Authors: Ballut, L., Violot, S., Carrique, L., Aghajari, N.		Authors: Ballut, L., Violot, S., Carrique, L., Aghajari, N.

OCA: Protected "7o7a" [edit=sysop:move=sysop]

2021-04-21T06:40:19Z

Protected "7o7a" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:40, 21 April 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7o7a is ON HOLD Authors: Ballut, L., Violot, S., Carrique, L., Aghajari, N. Description: Structure of the PL6 family alginate lyase Pedsa0632 from ...

2021-04-21T06:40:17Z

New page: '''Unreleased structure''' The entry 7o7a is ON HOLD Authors: Ballut, L., Violot, S., Carrique, L., Aghajari, N. Description: Structure of the PL6 family alginate lyase Pedsa0632 from ...

New page

'''Unreleased structure'''

The entry 7o7a is ON HOLD

Authors: Ballut, L., Violot, S., Carrique, L., Aghajari, N.

Description: Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans
[[Category: Unreleased Structures]]
[[Category: Carrique, L]]
[[Category: Violot, S]]
[[Category: Aghajari, N]]
[[Category: Ballut, L]]