OCA at 13:03, 1 February 2024

2024-02-01T13:03:51Z

← Older revision		Revision as of 13:03, 1 February 2024
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	==The PDZ domain of SNX27 fused with ANXA2==		==The PDZ domain of SNX27 fused with ANXA2==
	<StructureSection load='7pcb' size='340' side='right'caption='[[7pcb]]' scene=''>		<StructureSection load='7pcb' size='340' side='right'caption='[[7pcb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7pcb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PCB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pcb OCA], [https://pdbe.org/7pcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pcb RCSB], [https://www.ebi.ac.uk/pdbsum/7pcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pcb ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pcb OCA], [https://pdbe.org/7pcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pcb RCSB], [https://www.ebi.ac.uk/pdbsum/7pcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pcb ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/SNX27_HUMAN SNX27_HUMAN] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).<ref>PMID:17351151</ref> [https://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The human PDZome represents one of the largest globular domain families in the human proteome, with 266 instances. These globular domains typically interact with C-terminal peptide motifs found in thousands of human proteins. Despite previous efforts, not all PDZ domains have experimentally solved structures and most of their complexes remain to be solved. Here, a simple and cost-effective strategy is proposed for the crystallization of PDZ domains and their complexes. A human annexin A2 fusion tag was used as a crystallization chaperone and the structures of nine PDZ domains were solved, including five domains that had not yet been solved. Finally, these novel experimental structures were compared with AlphaFold predictions and it is speculated how predictions and experimental methods could cooperate in order to investigate the structural landscapes of entire domain families and interactomes.

			A scalable strategy to solve structures of PDZ domains and their complexes.,Cousido-Siah A, Carneiro L, Kostmann C, Ecsedi P, Nyitray L, Trave G, Gogl G Acta Crystallogr D Struct Biol. 2022 Apr 1;78(Pt 4):509-516. doi:, 10.1107/S2059798322001784. Epub 2022 Mar 11. PMID:35362473<ref>PMID:35362473</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7pcb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cousido-Siah A]]		[[Category: Cousido-Siah A]]
	[[Category: Gogl G]]		[[Category: Gogl G]]
	[[Category: Trave G]]		[[Category: Trave G]]

OCA at 02:54, 21 April 2022

2022-04-21T02:54:50Z

← Older revision		Revision as of 02:54, 21 April 2022
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	~~'''Unreleased structure'''~~

	The ~~entry~~ 7pcb ~~is ON HOLD until Paper Publication~~		==The PDZ domain of SNX27 fused with ANXA2==
			<StructureSection load='7pcb' size='340' side='right'caption='[[7pcb]]' scene=''>
	~~Authors~~: ~~Cousido~~-~~Siah~~, A., ~~Trave~~, G., ~~Gogl~~, G.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PCB FirstGlance]. <br>
	~~Description: The PDZ domain of SNX27 fused with ANXA2~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pcb OCA], [https://pdbe.org/7pcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pcb RCSB], [https://www.ebi.ac.uk/pdbsum/7pcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pcb ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Cousido-Siah, A]]		__TOC__
	[[Category: Gogl, G]]		</StructureSection>
	[[Category: Trave, G]]		[[Category: Large Structures]]
			[[Category: Cousido-Siah A]]
			[[Category: Gogl G]]
			[[Category: Trave G]]

OCA: Protected "7pcb" [edit=sysop:move=sysop]

2021-08-11T05:05:52Z

Protected "7pcb" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:05, 11 August 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7pcb is ON HOLD until Paper Publication Authors: Cousido-Siah, A., Trave, G., Gogl, G. Description: The PDZ domain of SNX27 fused with ANXA2 [[Cate...

2021-08-11T05:05:51Z

New page: '''Unreleased structure''' The entry 7pcb is ON HOLD until Paper Publication Authors: Cousido-Siah, A., Trave, G., Gogl, G. Description: The PDZ domain of SNX27 fused with ANXA2 [[Cate...

New page

'''Unreleased structure'''

The entry 7pcb is ON HOLD until Paper Publication

Authors: Cousido-Siah, A., Trave, G., Gogl, G.

Description: The PDZ domain of SNX27 fused with ANXA2
[[Category: Unreleased Structures]]
[[Category: Cousido-Siah, A]]
[[Category: Gogl, G]]
[[Category: Trave, G]]

7pcb - Revision history

OCA at 13:03, 1 February 2024

OCA at 02:54, 21 April 2022

OCA: Protected "7pcb" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7pcb is ON HOLD until Paper Publication Authors: Cousido-Siah, A., Trave, G., Gogl, G. Description: The PDZ domain of SNX27 fused with ANXA2 [[Cate...