7ppa - Revision history

OCA at 13:54, 6 November 2024

2024-11-06T13:54:19Z

← Older revision		Revision as of 13:54, 6 November 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/BMPR2_HUMAN BMPR2_HUMAN] Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:[https://omim.org/entry/178600 178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.<ref>PMID:10903931</ref> <ref>PMID:11015450</ref> <ref>PMID:10973254</ref> <ref>PMID:11115378</ref> <ref>PMID:12358323</ref> <ref>PMID:15965979</ref> Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:[https://omim.org/entry/265450 265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.<ref>PMID:12446270</ref> <ref>PMID:16429395</ref>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~BMP10_HUMAN BMP10_HUMAN~~] ~~Required for maintaining the proliferative activity~~ of ~~embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C~~/~~p57KIP~~ and ~~maintaining the required expression levels of cardiogenic factors such as MEF2C~~ and ~~NKX2~~-~~5. Acts as a ligand for ACVRL1/ALK1~~, ~~BMPR1A/ALK3~~ and ~~BMPR1B/ALK6~~, ~~leading to activation of SMAD1~~, ~~SMAD5 and SMAD8 transcription factors~~. ~~Inhibits endothelial cell migration and growth~~. ~~May reduce cell migration and cell matrix adhesion in breast cancer cell lines.<ref>PMID:16049014</ref> <ref>PMID:17068149</ref> <ref>PMID:20608934</ref>~~		[https://www.uniprot.org/uniprot/BMPR2_HUMAN BMPR2_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:07, 1 February 2024

2024-02-01T13:07:11Z

← Older revision		Revision as of 13:07, 1 February 2024
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	==High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10==		==High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10==
	<StructureSection load='7ppa' size='340' side='right'caption='[[7ppa]]' scene=''>		<StructureSection load='7ppa' size='340' side='right'caption='[[7ppa]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPA FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ppa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/BMP10_HUMAN BMP10_HUMAN] Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.<ref>PMID:16049014</ref> <ref>PMID:17068149</ref> <ref>PMID:20608934</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is unknown. To elucidate the molecular basis of BMP:BMPRII interactions, we report crystal structures of binary and ternary BMPRII receptor complexes with BMP10, which contain an ensemble of seven different BMP10:BMPRII 1:1 complexes. BMPRII binds BMP10 at the knuckle epitope, with the A-loop and beta4 strand making BMPRII-specific interactions. The BMPRII binding surface on BMP10 is dynamic, and the affinity is weaker in the ternary complex than in the binary complex. Hydrophobic core and A-loop interactions are important in BMPRII-mediated signalling. Our data reveal how BMPRII is a low affinity receptor, implying that forming a signalling complex requires high concentrations of BMPRII, hence mutations will impact on tissues with highest BMPR2 expression such as the lung vasculature.

			Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.,Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, Salmon RM, Read RJ, Ten Dijke P, Morrell NW, Li W Nat Commun. 2022 May 3;13(1):2395. doi: 10.1038/s41467-022-30111-2. PMID:35504921<ref>PMID:35504921</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7ppa" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Bone morphogenetic protein 3D structures\|Bone morphogenetic protein 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Guo J]]		[[Category: Guo J]]

OCA at 14:34, 31 August 2022

2022-08-31T14:34:21Z

← Older revision		Revision as of 14:34, 31 August 2022
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	====		==High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10==
	<StructureSection load='7ppa' size='340' side='right'caption='[[7ppa]]' scene=''>		<StructureSection load='7ppa' size='340' side='right'caption='[[7ppa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Guo J]]
			[[Category: Li W]]
			[[Category: Read RJ]]
			[[Category: Yu M]]

OCA at 06:18, 12 May 2022

2022-05-12T06:18:56Z

← Older revision		Revision as of 06:18, 12 May 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7ppa is ~~ON HOLD until Paper Publication~~		====
			<StructureSection load='7ppa' size='340' side='right'caption='[[7ppa]]' scene=''>
	~~Authors:~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppa OCA], [https://pdbe.org/7ppa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppa RCSB], [https://www.ebi.ac.uk/pdbsum/7ppa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppa ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA at 07:37, 29 September 2021

2021-09-29T07:37:34Z

← Older revision		Revision as of 07:37, 29 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7ppa is ON HOLD		The entry 7ppa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ppa" [edit=sysop:move=sysop]

2021-09-22T05:31:08Z

Protected "7ppa" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:31, 22 September 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7ppa is ON HOLD Authors: Description: Category: Unreleased Structures

2021-09-22T05:31:07Z

New page: '''Unreleased structure''' The entry 7ppa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ppa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]