7ps3 - Revision history

OCA at 13:08, 1 February 2024

2024-02-01T13:08:24Z

← Older revision		Revision as of 13:08, 1 February 2024
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	====		==Crystal structure of antibody Beta-32 Fab==
	<StructureSection load='7ps3' size='340' side='right'caption='[[7ps3]]' scene=''>		<StructureSection load='7ps3' size='340' side='right'caption='[[7ps3]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ps3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PS3 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ps3 OCA], [https://pdbe.org/7ps3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ps3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ps3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ps3 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ps3 OCA], [https://pdbe.org/7ps3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ps3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ps3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ps3 ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the antigenic structure of S, causing escape from natural or vaccine-induced immunity. Beta is particularly difficult to neutralize using serum induced by early pandemic SARS-CoV-2 strains and is most antigenically separated from Delta. To understand this, we generated 674 mAbs from Beta-infected individuals and performed a detailed structure-function analysis of the 27 most potent mAbs: one binding the spike N-terminal domain (NTD), the rest the receptor-binding domain (RBD). Two of these RBD-binding mAbs recognize a neutralizing epitope conserved between SARS-CoV-1 and -2, while 18 target mutated residues in Beta: K417N, E484K, and N501Y. There is a major response to N501Y, including a public IgVH4-39 sequence, with E484K and K417N also targeted. Recognition of these key residues underscores why serum from Beta cases poorly neutralizes early pandemic and Delta viruses.

			The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.,Liu C, Zhou D, Nutalai R, Duyvesteyn HME, Tuekprakhon A, Ginn HM, Dejnirattisai W, Supasa P, Mentzer AJ, Wang B, Case JB, Zhao Y, Skelly DT, Chen RE, Johnson SA, Ritter TG, Mason C, Malik T, Temperton N, Paterson NG, Williams MA, Hall DR, Clare DK, Howe A, Goulder PJR, Fry EE, Diamond MS, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR Cell Host Microbe. 2022 Jan 12;30(1):53-68.e12. doi: 10.1016/j.chom.2021.11.013. , Epub 2021 Nov 27. PMID:34921776<ref>PMID:34921776</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7ps3" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Antibody 3D structures\|Antibody 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Ren J]]
			[[Category: Stuart DI]]
			[[Category: Zhou D]]

OCA at 16:49, 15 December 2021

2021-12-15T16:49:24Z

← Older revision		Revision as of 16:49, 15 December 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7ps3 ~~is ON HOLD until Paper Publication~~		====
			<StructureSection load='7ps3' size='340' side='right'caption='[[7ps3]]' scene=''>
	~~Authors~~: ~~Zhou, D~~.~~, Ren, J~~.~~, Stuart, D~~.I.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~: ~~Crystal structure of antibody Beta-32 Fab~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ps3 OCA], [https://pdbe.org/7ps3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ps3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ps3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ps3 ProSAT]</span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		</table>
	[[~~Category~~: ~~Ren~~, J]]		__TOC__
	[[Category: ~~Stuart, D.I~~]]		</StructureSection>
	[[Category: ~~Zhou, D~~]]		[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA at 14:54, 20 October 2021

2021-10-20T14:54:00Z

← Older revision		Revision as of 14:54, 20 October 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7ps3 is ON HOLD		The entry 7ps3 is ON HOLD until Paper Publication

	Authors: Zhou, D., Ren, J., Stuart, D.I.		Authors: Zhou, D., Ren, J., Stuart, D.I.
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	Description: Crystal structure of antibody Beta-32 Fab		Description: Crystal structure of antibody Beta-32 Fab
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Zhou, D]]~~
	[[Category: Ren, J]]		[[Category: Ren, J]]
	[[Category: Stuart, D.I]]		[[Category: Stuart, D.I]]
			[[Category: Zhou, D]]

OCA: Protected "7ps3" [edit=sysop:move=sysop]

2021-09-29T07:40:41Z

Protected "7ps3" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:40, 29 September 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7ps3 is ON HOLD Authors: Zhou, D., Ren, J., Stuart, D.I. Description: Crystal structure of antibody Beta-32 Fab Category: Unreleased Structures...

2021-09-29T07:40:40Z

New page: '''Unreleased structure''' The entry 7ps3 is ON HOLD Authors: Zhou, D., Ren, J., Stuart, D.I. Description: Crystal structure of antibody Beta-32 Fab Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 7ps3 is ON HOLD

Authors: Zhou, D., Ren, J., Stuart, D.I.

Description: Crystal structure of antibody Beta-32 Fab
[[Category: Unreleased Structures]]
[[Category: Zhou, D]]
[[Category: Ren, J]]
[[Category: Stuart, D.I]]