7q04 - Revision history

OCA at 19:13, 8 September 2026

2026-09-08T19:13:56Z

← Older revision		Revision as of 19:13, 8 September 2026
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	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~LYSC_CHICK LYSC_CHICK~~] ~~Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with~~ the ~~monocyte~~-~~macrophage~~ system ~~and enhance~~ the ~~activity~~ of ~~immunoagents~~. ~~Has bacteriolytic activity against M.luteus~~.<ref>PMID:~~22044478~~</ref>		[https://www.uniprot.org/uniprot/TPDB1_COMSP TPDB1_COMSP] Component of the terephthalate 1,2-dioxygenase multicomponent enzyme system which catalyzes the dioxygenation of terephthalate (TER/TPA) to 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid (DCD). It can also use 2,5-dicarboxypyridine (PDC) and 1,4-napthalenedicarboxylic acid (NDC) as substrates, and preferentially uses NADPH which is the physiological electron donor.<ref>PMID:16517628</ref> <ref>PMID:18776687</ref> <ref>PMID:7961417</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	SignificanceMore than 400 million tons of plastic waste is produced each year, the overwhelming majority of which ends up in landfills. Bioconversion strategies aimed at plastics have emerged as important components of enabling a circular economy for synthetic plastics, especially those that exhibit chemically similar linkages to those found in nature, such as polyesters. The enzyme system described in this work is essential for mineralization of the xenobiotic components of poly(ethylene terephthalate) (PET) in the biosphere. Our description of its structure and substrate preferences lays the groundwork for in vivo or ex vivo engineering of this system for PET upcycling.		SignificanceMore than 400 million tons of plastic waste is produced each year, the overwhelming majority of which ends up in landfills. Bioconversion strategies aimed at plastics have emerged as important components of enabling a circular economy for synthetic plastics, especially those that exhibit chemically similar linkages to those found in nature, such as polyesters. The enzyme system described in this work is essential for mineralization of the xenobiotic components of poly(ethylene terephthalate) (PET) in the biosphere. Our description of its structure and substrate preferences lays the groundwork for in vivo or ex vivo engineering of this system for PET upcycling.

	Biochemical and structural characterization of an aromatic ring-hydroxylating dioxygenase for terephthalic acid catabolism.,Kincannon WM, Zahn M, Clare R, Lusty Beech J, Romberg A, Larson J, Bothner B, Beckham GT, McGeehan JE, DuBois JL Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2121426119. doi:, 10.1073/pnas.2121426119. Epub 2022 Mar 21. PMID:35312352<ref>PMID:35312352</ref>		Biochemical and structural characterization of an aromatic ring-hydroxylating dioxygenase for terephthalic acid catabolism.,Kincannon WM, Zahn M, Clare R, Lusty Beech J, Romberg A, Larson J, Bothner B, Beckham GT, McGeehan JE, DuBois JL Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2121426119. doi: , 10.1073/pnas.2121426119. Epub 2022 Mar 21. PMID:35312352<ref>PMID:35312352</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

OCA at 13:11, 1 February 2024

2024-02-01T13:11:44Z

← Older revision		Revision as of 13:11, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7q04]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_sp. Comamonas sp.] and [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7q04]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_sp. Comamonas sp.] and [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.281Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q04 OCA], [https://pdbe.org/7q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q04 RCSB], [https://www.ebi.ac.uk/pdbsum/7q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q04 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q04 OCA], [https://pdbe.org/7q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q04 RCSB], [https://www.ebi.ac.uk/pdbsum/7q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q04 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>		[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:56, 7 September 2022

2022-09-07T18:56:21Z

← Older revision		Revision as of 18:56, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>		[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			SignificanceMore than 400 million tons of plastic waste is produced each year, the overwhelming majority of which ends up in landfills. Bioconversion strategies aimed at plastics have emerged as important components of enabling a circular economy for synthetic plastics, especially those that exhibit chemically similar linkages to those found in nature, such as polyesters. The enzyme system described in this work is essential for mineralization of the xenobiotic components of poly(ethylene terephthalate) (PET) in the biosphere. Our description of its structure and substrate preferences lays the groundwork for in vivo or ex vivo engineering of this system for PET upcycling.

			Biochemical and structural characterization of an aromatic ring-hydroxylating dioxygenase for terephthalic acid catabolism.,Kincannon WM, Zahn M, Clare R, Lusty Beech J, Romberg A, Larson J, Bothner B, Beckham GT, McGeehan JE, DuBois JL Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2121426119. doi:, 10.1073/pnas.2121426119. Epub 2022 Mar 21. PMID:35312352<ref>PMID:35312352</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7q04" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:48, 7 September 2022

2022-09-07T16:48:07Z

← Older revision		Revision as of 16:48, 7 September 2022
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	====		==Crystal structure of TPADO in a substrate-free state==
	<StructureSection load='7q04' size='340' side='right'caption='[[7q04]]' scene=''>		<StructureSection load='7q04' size='340' side='right'caption='[[7q04]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7q04]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_sp. Comamonas sp.] and [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q04 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q04 OCA], [https://pdbe.org/7q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q04 RCSB], [https://www.ebi.ac.uk/pdbsum/7q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q04 ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q04 OCA], [https://pdbe.org/7q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q04 RCSB], [https://www.ebi.ac.uk/pdbsum/7q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q04 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Comamonas sp]]
			[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: DuBois JL]]
			[[Category: Kincannon WM]]
			[[Category: McGeehan JE]]
			[[Category: Zahn M]]

OCA at 10:24, 6 April 2022

2022-04-06T10:24:47Z

← Older revision		Revision as of 10:24, 6 April 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7q04 is ~~ON HOLD~~		====
			<StructureSection load='7q04' size='340' side='right'caption='[[7q04]]' scene=''>
	~~Authors:~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q04 OCA], [https://pdbe.org/7q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q04 RCSB], [https://www.ebi.ac.uk/pdbsum/7q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q04 ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA: Protected "7q04" [edit=sysop:move=sysop]

2021-10-20T15:01:36Z

Protected "7q04" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:01, 20 October 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7q04 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-10-20T15:01:35Z

New page: '''Unreleased structure''' The entry 7q04 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7q04 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]