7req - Revision history

OCA at 14:32, 13 August 2026

2026-08-13T14:32:20Z

← Older revision		Revision as of 14:32, 13 August 2026
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REQ FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CP:2-CARBOXYPROPYL-COENZYME+A'>2CP~~</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12~~</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CP:2-CARBOXYPROPYL-COENZYME+A'>2CP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [https://pdbe.org/7req PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [https://www.ebi.ac.uk/pdbsum/7req PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7req ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [https://pdbe.org/7req PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [https://www.ebi.ac.uk/pdbsum/7req PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7req ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/7req_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/7req_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 18:10, 20 September 2023

2023-09-20T18:10:01Z

← Older revision		Revision as of 18:10, 20 September 2023
Line 1:		Line 1:

	==METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX==		==METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX==
	<StructureSection load='7req' size='340' side='right' caption='[[7req]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='7req' size='340' side='right'caption='[[7req]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"propionibacterium_shermanii"_van_niel_1928 "propionibacterium~~ shermanii~~" van niel 1928~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=7REQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REQ FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=2CP:2~~-~~CARBOXYPROPYL-COENZYME+A'>2CP</scene>~~, ~~<scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MUTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1752~~ "~~Propionibacterium shermanii~~" ~~van Niel 1928]), MUTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CP:2-CARBOXYPROPYL-COENZYME+A'>2CP</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [https://pdbe.org/7req PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [https://www.ebi.ac.uk/pdbsum/7req PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7req ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [~~http~~://pdbe.org/7req PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7req PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7req ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/MUTB_PROFR MUTB_PROFR~~]] Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. [[http://www.uniprot.org/uniprot/MUTA_PROFR MUTA_PROFR]~~] Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.		[https://www.uniprot.org/uniprot/MUTB_PROFR MUTB_PROFR] Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/7req_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/7req_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Propionibacterium shermanii van niel 1928~~]]		[[Category: Large Structures]]
	[[Category: ~~Methylmalonyl-CoA mutase~~]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]
	[[Category: Evans~~, P R~~]]		[[Category: Evans PR]]
	[[Category: Mancia, F]]		[[Category: Mancia F]]
	~~[[Category: Intramolecular transferase]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Mutase~~]]

OCA at 07:09, 5 August 2016

2016-08-05T07:09:42Z

← Older revision		Revision as of 07:09, 5 August 2016
Line 1:		Line 1:

	==METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX==		==METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX==
	<StructureSection load='7req' size='340' side='right' caption='[[7req]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='7req' size='340' side='right' caption='[[7req]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp.~~ shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7REQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"propionibacterium_shermanii"_van_niel_1928 "propionibacterium shermanii" van niel 1928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7REQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CP:2-CARBOXYPROPYL-COENZYME+A'>2CP</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CP:2-CARBOXYPROPYL-COENZYME+A'>2CP</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium ~~freudenreichii subsp.~~ shermanii]), MUTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium ~~freudenreichii subsp.~~ shermanii])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928]), MUTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [http://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [http://www.ebi.ac.uk/pdbsum/7req PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [http://pdbe.org/7req PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [http://www.ebi.ac.uk/pdbsum/7req PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7req ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=7req ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 7req" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Propionibacterium shermanii van niel 1928]]
	[[Category: Methylmalonyl-CoA mutase]]		[[Category: Methylmalonyl-CoA mutase]]
	~~[[Category: Propionibacterium freudenreichii subsp. shermanii]]~~
	[[Category: Evans, P R]]		[[Category: Evans, P R]]
	[[Category: Mancia, F]]		[[Category: Mancia, F]]

OCA at 16:45, 25 December 2014

2014-12-25T16:45:41Z

← Older revision		Revision as of 16:45, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [http://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [http://www.ebi.ac.uk/pdbsum/7req PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [http://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [http://www.ebi.ac.uk/pdbsum/7req PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MUTB_PROFR MUTB_PROFR]] Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. [[http://www.uniprot.org/uniprot/MUTA_PROFR MUTA_PROFR]] Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:01, 10 December 2014

2014-12-10T17:01:47Z

← Older revision		Revision as of 17:01, 10 December 2014
Line 1:		Line 1:
	[[Image:~~7req~~.~~png~~\|~~left~~\|~~200px~~]]		==METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX==
			<StructureSection load='7req' size='340' side='right' caption='[[7req]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[7req]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7REQ FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CP:2-CARBOXYPROPYL-COENZYME+A'>2CP</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii]), MUTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7req OCA], [http://www.rcsb.org/pdb/explore.do?structureId=7req RCSB], [http://www.ebi.ac.uk/pdbsum/7req PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/7req_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			X-ray crystal structures of methylmalonyl-CoA mutase in complexes with substrate methylmalonyl-CoA and inhibitors 2-carboxypropyl-CoA and 3-carboxypropyl-CoA (substrate and product analogues) show that the enzyme-substrate interactions change little during the course of the rearrangement reaction, in contrast to the large conformational change on substrate binding. The substrate complex shows a 5'-deoxyadenine molecule in the active site, bound weakly and not attached to the cobalt atom of coenzyme B12, rotated and shifted from its position in the substrate-free adenosylcobalamin complex. The position of Tyralpha89 close to the substrate explains the stereochemical selectivity of the enzyme for (2R)-methylmalonyl-CoA.

	~~{{STRUCTURE_7req\| PDB=7req \| SCENE= }}~~		Crystal structure of substrate complexes of methylmalonyl-CoA mutase.,Mancia F, Smith GA, Evans PR Biochemistry. 1999 Jun 22;38(25):7999-8005. PMID:10387043<ref>PMID:10387043</ref>

	~~===METHYLMALONYL-COA MUTASE~~, ~~2-CARBOXYPROPYL-COA INHIBITOR COMPLEX===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_10387043}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[7req]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Propionibacterium_freudenreichii_subsp~~.~~_shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:010387043<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Methylmalonyl-CoA mutase]]		[[Category: Methylmalonyl-CoA mutase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]
	[[Category: Evans, P R.]]		[[Category: Evans, P R]]
	[[Category: Mancia, F.]]		[[Category: Mancia, F]]
	[[Category: Intramolecular transferase]]		[[Category: Intramolecular transferase]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Mutase]]		[[Category: Mutase]]

OCA: Protected "7req" [edit=sysop:move=sysop]

2012-10-24T06:35:56Z

Protected "7req" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:35, 24 October 2012
(No difference)

OCA at 06:35, 24 October 2012

2012-10-24T06:35:55Z

← Older revision		Revision as of 06:35, 24 October 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:7req.png\|left\|200px]]		[[Image:7req.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_7req", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_7req\| PDB=7req \| SCENE= }}		{{STRUCTURE_7req\| PDB=7req \| SCENE= }}

	===METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX===		===METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_10387043}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 10387043 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_10387043}}		{{ABSTRACT_PUBMED_10387043}}

	==About this Structure==		==About this Structure==
	~~7REQ~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA].		[[7req]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~10387043~~</ref><references group="xtra"/>		<ref group="xtra">PMID:010387043</ref><references group="xtra"/>
	[[Category: Methylmalonyl-CoA mutase]]		[[Category: Methylmalonyl-CoA mutase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]
Line 31:		Line 19:
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Mutase]]		[[Category: Mutase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:07:31 2009''~~

OCA at 20:07, 17 February 2009

2009-02-17T20:07:33Z

← Older revision		Revision as of 20:07, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	7REQ is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA].		7REQ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REQ OCA].

	==Reference==		==Reference==
	~~Crystal structure of substrate complexes of methylmalonyl-CoA mutase., Mancia F, Smith GA, Evans PR, Biochemistry. 1999 Jun 22;38(25):7999-8005.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10387043 10387043]~~		<ref group="xtra">PMID:10387043</ref><references group="xtra"/>
	[[Category: Methylmalonyl-CoA mutase]]		[[Category: Methylmalonyl-CoA mutase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]
	~~[[Category: Protein complex]]~~
	[[Category: Evans, P R.]]		[[Category: Evans, P R.]]
	[[Category: Mancia, F.]]		[[Category: Mancia, F.]]
Line 33:		Line 32:
	[[Category: Mutase]]		[[Category: Mutase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 14~~:56:~~09 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:07:31 2009''

OCA at 11:56, 3 July 2008

2008-07-03T11:56:16Z

← Older revision		Revision as of 11:56, 3 July 2008
Line 1:		Line 1:
	[[Image:7req.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:7req.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_7req\| PDB=7req \| SCENE= }}		{{STRUCTURE_7req\| PDB=7req \| SCENE= }}

	~~'''~~METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX~~'''~~		===METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX===


	~~==Overview==~~		<!--
	X-~~ray crystal structures of methylmalonyl~~-~~CoA mutase in complexes with substrate methylmalonyl-CoA and inhibitors 2-carboxypropyl-CoA and 3-carboxypropyl-CoA (substrate and product analogues) show that~~ the ~~enzyme-substrate interactions change little during the course of the rearrangement reaction, in contrast~~ to the ~~large conformational change~~ on ~~substrate binding~~. ~~The substrate complex shows a 5'-deoxyadenine molecule in the active site~~, ~~bound weakly and not attached to~~ the ~~cobalt atom of coenzyme B12, rotated and shifted from its position in the substrate-free adenosylcobalamin complex~~. ~~The position of Tyralpha89 close to the substrate explains the stereochemical selectivity of the enzyme for (2R)~~-~~methylmalonyl~~-~~CoA.~~		The line below this paragraph, {{ABSTRACT_PUBMED_10387043}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 10387043 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_10387043}}

	==About this Structure==		==About this Structure==
Line 28:		Line 32:
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Mutase]]		[[Category: Mutase]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:47:35 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:56:09 2008''

OCA at 19:47, 4 May 2008

2008-05-04T19:47:35Z

← Older revision		Revision as of 19:47, 4 May 2008
Line 1:		Line 1:
	[[Image:7req.gif\|left\|200px]]		[[Image:7req.gif\|left\|200px]]

	~~{{Structure~~		<!--
	~~\|PDB= 7req \|SIZE=350\|CAPTION=~~ <~~scene name='initialview01'>7req</scene>, resolution 2.20Å~~		The line below this paragraph, containing "STRUCTURE_7req", creates the "Structure Box" on the page.
	~~\|SITE=~~		You may change the PDB parameter (which sets the PDB file loaded into the applet)
	~~\|LIGAND= <scene name='pdbligand=2CP:2~~-~~CARBOXYPROPYL~~-~~COENZYME+A'>2CP</scene>~~, ~~<scene name='pdbligand=B12:COBALAMIN'>B12</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~		or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
	\|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.~~2] </span>~~		or leave the SCENE parameter empty for the default display.
	~~\|GENE= MUTB~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii]~~)~~, MUTA~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii]~~)		-->
	~~\|DOMAIN=~~		{{STRUCTURE_7req\| PDB=7req \| SCENE= }}
	~~\|RELATEDENTRY=~~
	\|~~RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol~~=7req ~~FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id~~=~~7req OCA], [http://www.ebi.ac.uk/pdbsum/7req PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=7req RCSB]</span>~~
	}}

	'''METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX'''		'''METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX'''
Line 28:		Line 25:
	[[Category: Evans, P R.]]		[[Category: Evans, P R.]]
	[[Category: Mancia, F.]]		[[Category: Mancia, F.]]
	[[Category: ~~intramolecular~~ transferase]]		[[Category: Intramolecular transferase]]
	[[Category: ~~isomerase~~]]		[[Category: Isomerase]]
	[[Category: ~~mutase~~]]		[[Category: Mutase]]
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:47:35 2008''
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:44:42 2008''