7ror - Revision history

OCA at 16:34, 18 October 2023

2023-10-18T16:34:49Z

← Older revision		Revision as of 16:34, 18 October 2023
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	<StructureSection load='7ror' size='340' side='right'caption='[[7ror]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='7ror' size='340' side='right'caption='[[7ror]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ror]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROR FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ror]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=69X:5-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine'>69X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=69X:5-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine'>69X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ror OCA], [https://pdbe.org/7ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ror RCSB], [https://www.ebi.ac.uk/pdbsum/7ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ror ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ror OCA], [https://pdbe.org/7ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ror RCSB], [https://www.ebi.ac.uk/pdbsum/7ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ror ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8IAR7_PLAF7 Q8IAR7_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7ror" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7ror" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Tyrosine--tRNA ligase~~]]		[[Category: Plasmodium falciparum 3D7]]
	[[Category: Griffin~~, M D.W~~]]		[[Category: Griffin MDW]]
	[[Category: Metcalfe~~, R D~~]]		[[Category: Metcalfe RD]]
	[[Category: Morton~~, C J~~]]		[[Category: Morton CJ]]
	[[Category: Tilley, L]]		[[Category: Tilley L]]
	[[Category: Xie~~, S C]]~~		[[Category: Xie SC]]
	~~[[Category: Enzyme]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Malaria]]~~
	~~[[Category: Tyrosine-amp]]~~
	~~[[Category: Tyrosyl-trna synthetase~~]]

OCA at 07:33, 29 June 2022

2022-06-29T07:33:26Z

← Older revision		Revision as of 07:33, 29 June 2022
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	==Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP==		==Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP==
	<StructureSection load='7ror' size='340' side='right'caption='[[7ror]]' scene=''>		<StructureSection load='7ror' size='340' side='right'caption='[[7ror]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROR FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ror]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROR FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ror OCA], [https://pdbe.org/7ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ror RCSB], [https://www.ebi.ac.uk/pdbsum/7ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ror ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=69X:5-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine'>69X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ror OCA], [https://pdbe.org/7ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ror RCSB], [https://www.ebi.ac.uk/pdbsum/7ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ror ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5'-monophosphate-mimicking nucleoside sulfamates. The target enzyme catalyzes the formation of an inhibitory amino acid-sulfamate conjugate through a reaction-hijacking mechanism. We identified adenosine 5'-sulfamate as a broad-specificity compound that hijacks a range of aaRSs and ML901 as a specific reagent a specific reagent that hijacks a single aaRS in the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray crystallographic studies of plasmodium and human YRSs reveal differential flexibility of a loop over the catalytic site that underpins differential susceptibility to reaction hijacking by ML901.

			Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.,Xie SC, Metcalfe RD, Dunn E, Morton CJ, Huang SC, Puhalovich T, Du Y, Wittlin S, Nie S, Luth MR, Ma L, Kim MS, Pasaje CFA, Kumpornsin K, Giannangelo C, Houghton FJ, Churchyard A, Famodimu MT, Barry DC, Gillett DL, Dey S, Kosasih CC, Newman W, Niles JC, Lee MCS, Baum J, Ottilie S, Winzeler EA, Creek DJ, Williamson N, Parker MW, Brand S, Langston SP, Dick LR, Griffin MDW, Gould AE, Tilley L Science. 2022 Jun 3;376(6597):1074-1079. doi: 10.1126/science.abn0611. Epub 2022 , Jun 2. PMID:35653481<ref>PMID:35653481</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7ror" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Griffin ~~MDW~~]]		[[Category: Tyrosine--tRNA ligase]]
	[[Category: Metcalfe RD]]		[[Category: Griffin, M D.W]]
	[[Category: Morton CJ]]		[[Category: Metcalfe, R D]]
	[[Category: Tilley L]]		[[Category: Morton, C J]]
	[[Category: Xie SC]]		[[Category: Tilley, L]]
			[[Category: Xie, S C]]
			[[Category: Enzyme]]
			[[Category: Inhibitor]]
			[[Category: Ligase]]
			[[Category: Malaria]]
			[[Category: Tyrosine-amp]]
			[[Category: Tyrosyl-trna synthetase]]

OCA at 05:29, 8 June 2022

2022-06-08T05:29:33Z

← Older revision		Revision as of 05:29, 8 June 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7ror is ~~ON HOLD until Paper Publication~~		==Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP==
			<StructureSection load='7ror' size='340' side='right'caption='[[7ror]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROR FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ror OCA], [https://pdbe.org/7ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ror RCSB], [https://www.ebi.ac.uk/pdbsum/7ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ror ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Griffin MDW]]
			[[Category: Metcalfe RD]]
			[[Category: Morton CJ]]
			[[Category: Tilley L]]
			[[Category: Xie SC]]

OCA: Protected "7ror" [edit=sysop:move=sysop]

2021-08-11T05:11:36Z

Protected "7ror" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:11, 11 August 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7ror is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2021-08-11T05:11:35Z

New page: '''Unreleased structure''' The entry 7ror is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ror is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]