7sys - Revision history

OCA at 14:02, 6 November 2024

2024-11-06T14:02:03Z

← Older revision		Revision as of 14:02, 6 November 2024
Line 3:		Line 3:
	<StructureSection load='7sys' size='340' side='right'caption='[[7sys]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='7sys' size='340' side='right'caption='[[7sys]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7sys]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7sys]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_(isolate_1) Hepatitis C virus (isolate 1)], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SYS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~G1TJW1_RABIT G1TJW1_RABIT~~]]		[https://www.uniprot.org/uniprot/RS27_RABIT RS27_RABIT] Component of the small ribosomal subunit (PubMed:23873042, PubMed:25601755, PubMed:26245381, PubMed:27863242). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23873042, PubMed:25601755, PubMed:26245381, PubMed:27863242). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:23873042, PubMed:25601755, PubMed:26245381, PubMed:27863242). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit (PubMed:23873042, PubMed:25601755, PubMed:26245381, PubMed:27863242). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).[UniProtKB:P42677]<ref>PMID:23873042</ref> <ref>PMID:25601755</ref> <ref>PMID:26245381</ref> <ref>PMID:27863242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 7sys" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7sys" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA at 04:16, 8 September 2022

2022-09-08T04:16:09Z

← Older revision		Revision as of 04:16, 8 September 2022
Line 1:		Line 1:

	==Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII).==		==Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII).==
	<StructureSection load='7sys' size='340' side='right'caption='[[7sys]]' scene=''>		<StructureSection load='7sys' size='340' side='right'caption='[[7sys]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7sys]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SYS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/G1TJW1_RABIT G1TJW1_RABIT]]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hepatitis C virus mRNA contains an internal ribosome entry site (IRES) that mediates end-independent translation initiation, requiring a subset of eukaryotic initiation factors (eIFs). Biochemical studies revealed that direct binding of the IRES to the 40S ribosomal subunit places the initiation codon into the P site, where it base pairs with eIF2-bound Met-tRNAiMet forming a 48S initiation complex. Subsequently, eIF5 and eIF5B mediate subunit joining, yielding an elongation-competent 80S ribosome. Initiation can also proceed without eIF2, in which case Met-tRNAiMet is recruited directly by eIF5B. However, the structures of initiation complexes assembled on the HCV IRES, the transitions between different states, and the accompanying conformational changes have remained unknown. To fill these gaps, we now obtained cryo-EM structures of IRES initiation complexes, at resolutions up to 3.5 A, that cover all major stages from the initial ribosomal association, through eIF2-containing 48S initiation complexes, to eIF5B-containing complexes immediately prior to subunit joining. These structures provide insights into the dynamic network of 40S/IRES contacts, highlight the role of IRES domain II, and reveal conformational changes that occur during the transition from eIF2- to eIF5B-containing 48S complexes and prepare them for subunit joining.

			Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.,Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J EMBO J. 2022 Aug 16;41(16):e110581. doi: 10.15252/embj.2022110581. Epub 2022 Jul , 13. PMID:35822879<ref>PMID:35822879</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7sys" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
			[[Category: Oryctolagus cuniculus]]
	[[Category: Abaeva IS]]		[[Category: Abaeva IS]]
	[[Category: Brown ZP]]		[[Category: Brown ZP]]

OCA at 11:08, 31 August 2022

2022-08-31T11:08:36Z

← Older revision		Revision as of 11:08, 31 August 2022
Line 1:		Line 1:

	====		==Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII).==
	<StructureSection load='7sys' size='340' side='right'caption='[[7sys]]' scene=''>		<StructureSection load='7sys' size='340' side='right'caption='[[7sys]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SYS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>
	</table>		</table>
Line 9:		Line 9:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Abaeva IS]]
			[[Category: Brown ZP]]
			[[Category: De S]]
			[[Category: Frank J]]
			[[Category: Hellen CUT]]
			[[Category: Pestova TV]]

OCA at 18:04, 27 July 2022

2022-07-27T18:04:54Z

← Older revision		Revision as of 18:04, 27 July 2022
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 7sys is ~~ON HOLD~~		====
			<StructureSection load='7sys' size='340' side='right'caption='[[7sys]]' scene=''>
	~~Authors:~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sys OCA], [https://pdbe.org/7sys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sys RCSB], [https://www.ebi.ac.uk/pdbsum/7sys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sys ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA: Protected "7sys" [edit=sysop:move=sysop]

2021-12-01T05:16:22Z

Protected "7sys" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:16, 1 December 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7sys is ON HOLD Authors: Description: Category: Unreleased Structures

2021-12-01T05:16:21Z

New page: '''Unreleased structure''' The entry 7sys is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7sys is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]