7tml - Revision history

OCA at 05:22, 25 September 2024

2024-09-25T05:22:00Z

← Older revision		Revision as of 05:22, 25 September 2024
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	<StructureSection load='7tml' size='340' side='right'caption='[[7tml]], [[Resolution\|resolution]] 0.93Å' scene=''>		<StructureSection load='7tml' size='340' side='right'caption='[[7tml]], [[Resolution\|resolution]] 0.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[7tml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.93Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.93Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=I6W:ethyl+5-formyl[2,2-bipyridine]-5-carboxylate'>I6W</scene>, <scene name='pdbligand=I77:5-(hydrazinecarbonyl)[2,2-bipyridine]-5-carboxamide'>I77</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=I6W:ethyl+5-formyl[2,2-bipyridine]-5-carboxylate'>I6W</scene>, <scene name='pdbligand=I77:5-(hydrazinecarbonyl)[2,2-bipyridine]-5-carboxamide'>I77</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Synthetic construct]]~~
	[[Category: Nguyen AI]]		[[Category: Nguyen AI]]

OCA at 17:05, 18 October 2023

2023-10-18T17:05:48Z

← Older revision		Revision as of 17:05, 18 October 2023
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	<StructureSection load='7tml' size='340' side='right'caption='[[7tml]], [[Resolution\|resolution]] 0.93Å' scene=''>		<StructureSection load='7tml' size='340' side='right'caption='[[7tml]], [[Resolution\|resolution]] 0.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tml]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=I6W:ethyl+5-formyl[2,2-bipyridine]-5-carboxylate'>I6W</scene>, <scene name='pdbligand=I77:5-(hydrazinecarbonyl)[2,2-bipyridine]-5-carboxamide'>I77</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH~~</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.93Å</td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB~~</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=I6W:ethyl+5-formyl[2,2-bipyridine]-5-carboxylate'>I6W</scene>, <scene name='pdbligand=I77:5-(hydrazinecarbonyl)[2,2-bipyridine]-5-carboxamide'>I77</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tml OCA], [https://pdbe.org/7tml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tml RCSB], [https://www.ebi.ac.uk/pdbsum/7tml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tml OCA], [https://pdbe.org/7tml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tml RCSB], [https://www.ebi.ac.uk/pdbsum/7tml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tml ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Nguyen, A I~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Alpha]]~~		[[Category: Nguyen AI]]
	~~[[Category: Assembly]]~~
	~~[[Category: Bipyridine]]~~
	~~[[Category: De novo protein]]~~
	~~[[Category: Framework]]~~
	~~[[Category: Helix]]~~
	~~[[Category: Porous]]~~
	~~[[Category: Uic-1~~]]

OCA at 11:55, 27 April 2022

2022-04-27T11:55:40Z

← Older revision		Revision as of 11:55, 27 April 2022
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	==Porous framework formed by assembly of a bipyridyl-conjugated helical peptide==		==Porous framework formed by assembly of a bipyridyl-conjugated helical peptide==
	<StructureSection load='7tml' size='340' side='right'caption='[[7tml]]' scene=''>		<StructureSection load='7tml' size='340' side='right'caption='[[7tml]], [[Resolution\|resolution]] 0.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tml]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tml OCA], [https://pdbe.org/7tml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tml RCSB], [https://www.ebi.ac.uk/pdbsum/7tml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tml ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=I6W:ethyl+5-formyl[2,2-bipyridine]-5-carboxylate'>I6W</scene>, <scene name='pdbligand=I77:5-(hydrazinecarbonyl)[2,2-bipyridine]-5-carboxamide'>I77</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tml OCA], [https://pdbe.org/7tml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tml RCSB], [https://www.ebi.ac.uk/pdbsum/7tml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tml ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The evolution of proteins from simpler, self-assembled peptides provides a powerful blueprint for the design of complex synthetic materials. Previously, peptide-metal frameworks using short sequences (</=3 residues) have shown great promise as proteomimetic materials that exhibit sophisticated capabilities. However, their development has been hindered due to few variable residues and restricted choice of side-chains that are compatible with metal ions. Herein, we developed a noncovalent strategy featuring pi-stacking bipyridyl residues to assemble much longer peptides into crystalline frameworks that tolerate even previously incompatible acidic and basic functionalities and allow an unprecedented level of pore variations. Single-crystal X-ray structures are provided for all variants to guide and validate rational design. These materials exhibit hallmark proteomimetic behaviors such as guest-selective induced fit and assembly of multimetallic units. Significantly, we demonstrate facile optimization of the framework design to substantially increase affinity toward a complex organic molecule.

			Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework.,Heinz-Kunert SL, Pandya A, Dang VT, Tran PN, Ghosh S, McElheny D, Santarsiero BD, Ren Z, Nguyen AI J Am Chem Soc. 2022 Apr 20;144(15):7001-7009. doi: 10.1021/jacs.2c02146. Epub, 2022 Apr 7. PMID:35390261<ref>PMID:35390261</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7tml" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Nguyen AI]]		[[Category: Nguyen, A I]]
			[[Category: Alpha]]
			[[Category: Assembly]]
			[[Category: Bipyridine]]
			[[Category: De novo protein]]
			[[Category: Framework]]
			[[Category: Helix]]
			[[Category: Porous]]
			[[Category: Uic-1]]

OCA at 02:57, 21 April 2022

2022-04-21T02:57:24Z

← Older revision		Revision as of 02:57, 21 April 2022
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	~~'''Unreleased structure'''~~

	~~The entry 7tml is ON HOLD until Paper Publication~~		==Porous framework formed by assembly of a bipyridyl-conjugated helical peptide==
			<StructureSection load='7tml' size='340' side='right'caption='[[7tml]]' scene=''>
	~~Authors: Nguyen, A.I.~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TML FirstGlance]. <br>
	~~Description:~~ Porous framework formed by assembly of a bipyridyl-conjugated helical peptide		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tml OCA], [https://pdbe.org/7tml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tml RCSB], [https://www.ebi.ac.uk/pdbsum/7tml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tml ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Nguyen~~, A.I~~]]		__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Nguyen AI]]

OCA at 05:36, 2 February 2022

2022-02-02T05:36:49Z

← Older revision		Revision as of 05:36, 2 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7tml is ON HOLD		The entry 7tml is ON HOLD until Paper Publication

	Authors: Nguyen, A.I.		Authors: Nguyen, A.I.

OCA: Protected "7tml" [edit=sysop:move=sysop]

2022-01-27T05:36:26Z

Protected "7tml" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:36, 27 January 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7tml is ON HOLD Authors: Nguyen, A.I. Description: Porous framework formed by assembly of a bipyridyl-conjugated helical peptide [[Category: Unrele...

2022-01-27T05:36:25Z

New page: '''Unreleased structure''' The entry 7tml is ON HOLD Authors: Nguyen, A.I. Description: Porous framework formed by assembly of a bipyridyl-conjugated helical peptide [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 7tml is ON HOLD

Authors: Nguyen, A.I.

Description: Porous framework formed by assembly of a bipyridyl-conjugated helical peptide
[[Category: Unreleased Structures]]
[[Category: Nguyen, A.I]]