7tsk - Revision history

OCA at 14:42, 13 August 2026

2026-08-13T14:42:28Z

← Older revision		Revision as of 14:42, 13 August 2026
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	<table><tr><td colspan='2'>[[7tsk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tsk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.049Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.049Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K9C:4-methyl-6-[3-(methylamino)prop-1-~~yn-1-yl~~]pyridin-2-amine'>K9C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K9C:4-methyl-6-[3-(methylamino)prop-1-ynyl]pyridin-2-amine'>K9C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:07, 18 October 2023

2023-10-18T17:07:38Z

← Older revision		Revision as of 17:07, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tsk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tsk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K9C:4-methyl-6-[3-(methylamino)prop-1-yn-1-yl]pyridin-2-amine'>K9C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.049Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K9C:4-methyl-6-[3-(methylamino)prop-1-yn-1-yl]pyridin-2-amine'>K9C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>		[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>

			==See Also==
			*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:51, 8 September 2022

2022-09-08T05:51:39Z

← Older revision		Revision as of 05:51, 8 September 2022
Line 1:		Line 1:

	==Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine==		==Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine==
	<StructureSection load='7tsk' size='340' side='right'caption='[[7tsk]]' scene=''>		<StructureSection load='7tsk' size='340' side='right'caption='[[7tsk]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tsk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K9C:4-methyl-6-[3-(methylamino)prop-1-yn-1-yl]pyridin-2-amine'>K9C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li H]]		[[Category: Li H]]
	[[Category: Poulos TL]]		[[Category: Poulos TL]]

OCA at 05:17, 13 July 2022

2022-07-13T05:17:40Z

← Older revision		Revision as of 05:17, 13 July 2022
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	~~'''Unreleased structure'''~~

	~~The entry 7tsk is ON HOLD until Paper Publication~~		==Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine==
			<StructureSection load='7tsk' size='340' side='right'caption='[[7tsk]]' scene=''>
	~~Authors: Li, H., Poulos, T.L.~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSK FirstGlance]. <br>
	~~Description:~~ Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsk OCA], [https://pdbe.org/7tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsk RCSB], [https://www.ebi.ac.uk/pdbsum/7tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsk ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Li, H]]		__TOC__
	[[Category: Poulos~~, T.L~~]]		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Li H]]
			[[Category: Poulos TL]]

OCA at 09:08, 16 February 2022

2022-02-16T09:08:47Z

← Older revision		Revision as of 09:08, 16 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7tsk is ON HOLD		The entry 7tsk is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

OCA: Protected "7tsk" [edit=sysop:move=sysop]

2022-02-09T06:19:43Z

Protected "7tsk" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:19, 9 February 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7tsk is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methy...

2022-02-09T06:19:42Z

New page: '''Unreleased structure''' The entry 7tsk is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methy...

New page

'''Unreleased structure'''

The entry 7tsk is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine
[[Category: Unreleased Structures]]
[[Category: Li, H]]
[[Category: Poulos, T.L]]