7uce - Revision history

OCA at 17:13, 18 October 2023

2023-10-18T17:13:55Z

← Older revision		Revision as of 17:13, 18 October 2023
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	==Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment==		==Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment==
	<StructureSection load='7uce' size='340' side='right'caption='[[7uce]]' scene=''>		<StructureSection load='7uce' size='340' side='right'caption='[[7uce]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[7uce]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UCE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uce OCA], [https://pdbe.org/7uce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uce RCSB], [https://www.ebi.ac.uk/pdbsum/7uce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uce ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uce OCA], [https://pdbe.org/7uce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uce RCSB], [https://www.ebi.ac.uk/pdbsum/7uce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uce ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The induction of broadly neutralizing antibodies (bNAbs) is a potential strategy for a vaccine against HIV-1. However, most bNAbs exhibit features such as unusually high somatic hypermutation, including insertions and deletions, which make their induction challenging. VRC01-class bNAbs not only exhibit extraordinary breadth and potency but also rank among the most highly somatically mutated bNAbs. Here, we describe a VRC01-class antibody isolated from a viremic controller, BG24, that is much less mutated than most relatives of its class while achieving comparable breadth and potency. A 3.8-A x-ray crystal structure of a BG24-BG505 Env trimer complex revealed conserved contacts at the gp120 interface characteristic of the VRC01-class Abs, despite lacking common CDR3 sequence motifs. The existence of moderately mutated CD4-binding site (CD4bs) bNAbs such as BG24 provides a simpler blueprint for CD4bs antibody induction by a vaccine, raising the prospect that such an induction might be feasible with a germline-targeting approach.

			A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.,Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP Jr, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ Sci Adv. 2022 Aug 12;8(32):eabp8155. doi: 10.1126/sciadv.abp8155. Epub 2022 Aug, 12. PMID:35960796<ref>PMID:35960796</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7uce" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Antibody 3D structures\|Antibody 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barnes CO]]		[[Category: Barnes CO]]
	[[Category: Bjorkman PJ]]		[[Category: Bjorkman PJ]]

OCA at 11:10, 31 August 2022

2022-08-31T11:10:44Z

← Older revision		Revision as of 11:10, 31 August 2022
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	====		==Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment==
	<StructureSection load='7uce' size='340' side='right'caption='[[7uce]]' scene=''>		<StructureSection load='7uce' size='340' side='right'caption='[[7uce]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UCE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uce OCA], [https://pdbe.org/7uce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uce RCSB], [https://www.ebi.ac.uk/pdbsum/7uce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uce ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uce OCA], [https://pdbe.org/7uce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uce RCSB], [https://www.ebi.ac.uk/pdbsum/7uce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uce ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Barnes CO]]
			[[Category: Bjorkman PJ]]

OCA at 06:20, 18 August 2022

2022-08-18T06:20:21Z

← Older revision		Revision as of 06:20, 18 August 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7uce ~~is ON HOLD until Paper Publication~~		====
			<StructureSection load='7uce' size='340' side='right'caption='[[7uce]]' scene=''>
	~~Authors~~: ~~Barnes, C~~.O.~~, Bjorkman, P~~.J.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~: ~~Structure of the anti~~-~~HIV-1 neutralizing antibody BG24 Fab fragment~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uce OCA], [https://pdbe.org/7uce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uce RCSB], [https://www.ebi.ac.uk/pdbsum/7uce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uce ProSAT]</span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		</table>
	[[Category: ~~Barnes, C.O~~]]		__TOC__
	[[Category: ~~Bjorkman, P.J~~]]		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA at 09:02, 6 April 2022

2022-04-06T09:02:24Z

← Older revision		Revision as of 09:02, 6 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7uce is ON HOLD		The entry 7uce is ON HOLD until Paper Publication

	Authors: Barnes, C.O., Bjorkman, P.J.		Authors: Barnes, C.O., Bjorkman, P.J.

OCA: Protected "7uce" [edit=sysop:move=sysop]

2022-03-23T09:53:36Z

Protected "7uce" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:53, 23 March 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7uce is ON HOLD Authors: Barnes, C.O., Bjorkman, P.J. Description: Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment [[Category: ...

2022-03-23T09:53:35Z

New page: '''Unreleased structure''' The entry 7uce is ON HOLD Authors: Barnes, C.O., Bjorkman, P.J. Description: Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment [[Category: ...

New page

'''Unreleased structure'''

The entry 7uce is ON HOLD

Authors: Barnes, C.O., Bjorkman, P.J.

Description: Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment
[[Category: Unreleased Structures]]
[[Category: Barnes, C.O]]
[[Category: Bjorkman, P.J]]