7uvb - Revision history

OCA at 14:45, 13 August 2026

2026-08-13T14:45:51Z

← Older revision		Revision as of 14:45, 13 August 2026
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	<table><tr><td colspan='2'>[[7uvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7uvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UVB FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OHF:2-~~hydroxy-6-~~({~~(3S~~)-4-[2-(2-hydroxyethyl)~~pyridine~~-3-~~carbonyl~~]~~morpholin~~-3-yl}methoxy)benzaldehyde'>OHF</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OHF:2-[[(3~{S})-4-[2-(2-hydroxyethyl)pyridin-3-yl]carbonylmorpholin-3-yl]methoxy]-6-oxidanyl-benzaldehyde'>OHF</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uvb OCA], [https://pdbe.org/7uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uvb RCSB], [https://www.ebi.ac.uk/pdbsum/7uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uvb OCA], [https://pdbe.org/7uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uvb RCSB], [https://www.ebi.ac.uk/pdbsum/7uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uvb ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/HBA_HUMAN HBA_HUMAN] Involved in oxygen transport from the lung to the various peripheral tissues.		[https://www.uniprot.org/uniprot/HBA_HUMAN HBA_HUMAN] Involved in oxygen transport from the lung to the various peripheral tissues.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The pathophysiologic mechanism of sickle cell disease (SCD) involves polymerization of deoxygenated haemoglobin S (HbS), leading to red blood cell (RBC) sickling, decreased RBC deformability, microvascular obstruction, haemolysis, anaemia and downstream clinical complications. Pharmacological increase in the concentration of oxygenated HbS in RBCs has been shown to be a novel approach to inhibit HbS polymerization and reduce RBC sickling and haemolysis. We report that GBT021601, a small molecule that increases HbS-oxygen affinity, inhibits HbS polymerization and prevents RBC sickling in blood from patients with SCD. Moreover, in a murine model of SCD (SS mice), GBT021601 reduces RBC sickling, improves RBC deformability, prolongs RBC half-life and restores haemoglobin levels to the normal range, while improving oxygen delivery and increasing tolerance to severe hypoxia. Notably, oral dosing of GBT021601 in animals results in higher levels of Hb occupancy than voxelotor and suggests the feasibility of once-daily dosing in humans. In summary, GBT021601 improves RBC health and normalizes haemoglobin in SS mice, suggesting that it may be useful for the treatment of SCD. These data are being used as a foundation for clinical research and development of GBT021601.

	GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model.,Dufu K, Alt C, Strutt S, Partridge J, Tang T, Siu V, Liao-Zou H, Rademacher P, Williams AT, Muller CR, Geng X, Pochron MP, Dang AN, Cabrales P, Li Z, Oksenberg D, Cathers BE Br J Haematol. 2023 Mar 24. doi: 10.1111/bjh.18771. PMID:36960712<ref>PMID:36960712</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 7uvb" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 05:51, 5 July 2023

2023-07-05T05:51:16Z

← Older revision		Revision as of 05:51, 5 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7uvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7uvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OHF:2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde'>OHF</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OHF:2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde'>OHF</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uvb OCA], [https://pdbe.org/7uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uvb RCSB], [https://www.ebi.ac.uk/pdbsum/7uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uvb OCA], [https://pdbe.org/7uvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uvb RCSB], [https://www.ebi.ac.uk/pdbsum/7uvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uvb ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 7uvb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7uvb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:22, 7 April 2023

2023-04-07T06:22:20Z

@@ Line 1: / Line 1: @@
-The entry 7uvb is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601==
-Authors:
+GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model.,Dufu K, Alt C, Strutt S, Partridge J, Tang T, Siu V, Liao-Zou H, Rademacher P, Williams AT, Muller CR, Geng X, Pochron MP, Dang AN, Cabrales P, Li Z, Oksenberg D, Cathers BE Br J Haematol. 2023 Mar 24. doi: 10.1111/bjh.18771. PMID:36960712<ref>PMID:36960712</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 03:24, 18 August 2022

2022-08-18T03:24:18Z

← Older revision		Revision as of 03:24, 18 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7uvb is ON HOLD		The entry 7uvb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7uvb" [edit=sysop:move=sysop]

2022-05-12T04:47:57Z

Protected "7uvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:47, 12 May 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7uvb is ON HOLD Authors: Description: Category: Unreleased Structures

2022-05-12T04:47:55Z

New page: '''Unreleased structure''' The entry 7uvb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7uvb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]