7vbw - Revision history

OCA at 17:22, 29 November 2023

2023-11-29T17:22:48Z

← Older revision		Revision as of 17:22, 29 November 2023
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	<StructureSection load='7vbw' size='340' side='right'caption='[[7vbw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='7vbw' size='340' side='right'caption='[[7vbw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7vbw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBW FirstGlance]. <br>		<table><tr><td colspan='2'>[[7vbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbw OCA], [https://pdbe.org/7vbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbw RCSB], [https://www.ebi.ac.uk/pdbsum/7vbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbw OCA], [https://pdbe.org/7vbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbw RCSB], [https://www.ebi.ac.uk/pdbsum/7vbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbw ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A1V2W4X9_9BURK A0A1V2W4X9_9BURK]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Burkholderia cenocepacia]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gao~~, Y G~~]]		[[Category: Gao YG]]
	[[Category: Yan~~, X F~~]]		[[Category: Yan XF]]
	[[Category: Yong, Y]]		[[Category: Yong Y]]
	~~[[Category: Aaa+ atpase]]~~
	~~[[Category: Bacterial enhancer-binding protein]]~~
	~~[[Category: Quorum sensing]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcriptional regulator~~]]

OCA at 11:13, 16 February 2022

2022-02-16T11:13:03Z

← Older revision		Revision as of 11:13, 16 February 2022
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	==Structure of the GTP-bound AAA+ ATPase domain of the transcriptional regulator GtrR in Burkholderia cenocepacia==		==Structure of the GTP-bound AAA+ ATPase domain of the transcriptional regulator GtrR in Burkholderia cenocepacia==
	<StructureSection load='7vbw' size='340' side='right'caption='[[7vbw]]' scene=''>		<StructureSection load='7vbw' size='340' side='right'caption='[[7vbw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBW FirstGlance]. <br>		<table><tr><td colspan='2'>[[7vbw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBW FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbw OCA], [https://pdbe.org/7vbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbw RCSB], [https://www.ebi.ac.uk/pdbsum/7vbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbw ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbw OCA], [https://pdbe.org/7vbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbw RCSB], [https://www.ebi.ac.uk/pdbsum/7vbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbw ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Global transcriptional regulator downstream RpfR (GtrR) is a key downstream regulator for quorum-sensing signaling molecule cis-2-dodecenoic acid (BDSF). As a bacterial enhancer-binding protein (bEBP), GtrR is composed of an N-terminal receiver domain, a central ATPases associated with diverse cellular activities (AAA+) ATPase sigma(54) -interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. In this work, we solved its AAA+ ATPase domain in both apo and GTP-bound forms. The structure revealed how GtrR specifically recognizes GTP. In addition, we also revealed that GtrR has moderate GTPase activity in vitro in the absence of its activation signal. Finally, we found the residues K170, D236, R311, and R357 in GtrR that are crucial to its biological function, any single mutation leading to completely abolishing GtrR activity.

			Structural analyses of the AAA+ ATPase domain of the transcriptional regulator GtrR in the BDSF quorum-sensing system in Burkholderia cenocepacia.,Yan XF, Yang C, Wang M, Yong Y, Deng Y, Gao YG FEBS Lett. 2021 Nov 27. doi: 10.1002/1873-3468.14244. PMID:34837384<ref>PMID:34837384</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7vbw" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gao YG]]		[[Category: Gao, Y G]]
	[[Category: Yan XF]]		[[Category: Yan, X F]]
	[[Category: Yong Y]]		[[Category: Yong, Y]]
			[[Category: Aaa+ atpase]]
			[[Category: Bacterial enhancer-binding protein]]
			[[Category: Quorum sensing]]
			[[Category: Transcription]]
			[[Category: Transcriptional regulator]]

OCA at 16:51, 15 December 2021

2021-12-15T16:51:28Z

← Older revision		Revision as of 16:51, 15 December 2021
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7vbw is ~~ON HOLD until Paper Publication~~		==Structure of the GTP-bound AAA+ ATPase domain of the transcriptional regulator GtrR in Burkholderia cenocepacia==
			<StructureSection load='7vbw' size='340' side='right'caption='[[7vbw]]' scene=''>
	~~Authors~~: ~~Yan~~, X.F., ~~Yong~~, Y., ~~Gao~~, Y.G.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBW FirstGlance]. <br>
	~~Description: Structure of GTP-bound transcriptional factor from Burkholderia cenocepacia~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbw OCA], [https://pdbe.org/7vbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbw RCSB], [https://www.ebi.ac.uk/pdbsum/7vbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbw ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Yan, X.F~~]]		__TOC__
	[[Category: ~~Yong, Y~~]]		</StructureSection>
	[[Category: ~~Gao,~~ Y.G]]		[[Category: Large Structures]]
			[[Category: Gao YG]]
			[[Category: Yan XF]]
			[[Category: Yong Y]]

OCA at 08:25, 15 September 2021

2021-09-15T08:25:34Z

← Older revision		Revision as of 08:25, 15 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7vbw is ON HOLD		The entry 7vbw is ON HOLD until Paper Publication

	Authors: Yan, X.F., Yong, Y., Gao, Y.G.		Authors: Yan, X.F., Yong, Y., Gao, Y.G.

	Description: ~~AAA+ ATPase domain~~ of ~~GtrR~~ from Burkholderia cenocepacia ~~bound to GTP~~		Description: Structure of GTP-bound transcriptional factor from Burkholderia cenocepacia
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yan, X.F]]		[[Category: Yan, X.F]]
	[[Category: Yong, Y]]		[[Category: Yong, Y]]
	[[Category: Gao, Y.G]]		[[Category: Gao, Y.G]]

OCA: Protected "7vbw" [edit=sysop:move=sysop]

2021-09-08T08:03:55Z

Protected "7vbw" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:03, 8 September 2021
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7vbw is ON HOLD Authors: Yan, X.F., Yong, Y., Gao, Y.G. Description: AAA+ ATPase domain of GtrR from Burkholderia cenocepacia bound to GTP [[Catego...

2021-09-08T08:03:54Z

New page: '''Unreleased structure''' The entry 7vbw is ON HOLD Authors: Yan, X.F., Yong, Y., Gao, Y.G. Description: AAA+ ATPase domain of GtrR from Burkholderia cenocepacia bound to GTP [[Catego...

New page

'''Unreleased structure'''

The entry 7vbw is ON HOLD

Authors: Yan, X.F., Yong, Y., Gao, Y.G.

Description: AAA+ ATPase domain of GtrR from Burkholderia cenocepacia bound to GTP
[[Category: Unreleased Structures]]
[[Category: Yan, X.F]]
[[Category: Yong, Y]]
[[Category: Gao, Y.G]]