7wit - Revision history

OCA at 06:21, 3 July 2025

2025-07-03T06:21:46Z

← Older revision		Revision as of 06:21, 3 July 2025
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7wit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[7wit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9I0:(2S)-4-[(~~3aR~~,~~7aS~~)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic+acid'>9I0</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.21Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9I0:(2~{S})-4-[(3~{a}~{R},7~{a}~{S})-1,3,3~{a},4,5,6,7,7~{a}-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic+acid'>9I0</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wit OCA], [https://pdbe.org/7wit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wit RCSB], [https://www.ebi.ac.uk/pdbsum/7wit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wit ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wit OCA], [https://pdbe.org/7wit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wit RCSB], [https://www.ebi.ac.uk/pdbsum/7wit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wit ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	~~[https://www.uniprot.org/uniprot/A0A1U8CME7_MESAU A0A1U8CME7_MESAU] [https://www.uniprot.org/uniprot/A2VDS4_BOVIN A2VDS4_BOVIN]~~
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Mitiglinide is a highly selective fast-acting anti-diabetic drug that induces insulin secretion by inhibiting pancreatic KATP channels. However, how mitiglinide binds KATP channels remains unknown. Here, we show the cryo-EM structure of the SUR1 subunit complexed with mitiglinide. The structure reveals that mitiglinide binds inside the common insulin secretagogue-binding site of SUR1, which is surrounded by TM7, TM8, TM16, and TM17. Mitiglinide locks SUR1 in the NBD-separated inward-facing conformation. The detailed structural analysis of the mitiglinide-binding site uncovers the molecular basis of its high selectivity.

	Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide.,Wang M, Wu JX, Chen L Front Pharmacol. 2022 Jun 30;13:929684. doi: 10.3389/fphar.2022.929684., eCollection 2022. PMID:35847046<ref>PMID:35847046</ref>		==See Also==
			*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 7wit" style="background-color:#fffaf0;"></div>~~
	== ~~References~~ ==
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:07, 16 November 2022

2022-11-16T20:07:20Z

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-The entry 7wit is ON HOLD  until Paper Publication
+==Structure of SUR1 in complex with mitiglinide==
-Authors:
+Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide.,Wang M, Wu JX, Chen L Front Pharmacol. 2022 Jun 30;13:929684. doi: 10.3389/fphar.2022.929684., eCollection 2022. PMID:35847046<ref>PMID:35847046</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 06:04, 29 June 2022

2022-06-29T06:04:46Z

← Older revision		Revision as of 06:04, 29 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7wit is ON HOLD		The entry 7wit is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 03:55, 8 June 2022

2022-06-08T03:55:05Z

← Older revision		Revision as of 03:55, 8 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7wit is ON HOLD ~~until Paper Publication~~		The entry 7wit is ON HOLD

	Authors:		Authors:

OCA at 09:16, 16 February 2022

2022-02-16T09:16:34Z

← Older revision		Revision as of 09:16, 16 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7wit is ON HOLD		The entry 7wit is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7wit" [edit=sysop:move=sysop]

2022-01-12T08:46:48Z

Protected "7wit" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:46, 12 January 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7wit is ON HOLD Authors: Description: Category: Unreleased Structures

2022-01-12T08:46:47Z

New page: '''Unreleased structure''' The entry 7wit is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7wit is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]