7won - Revision history

OCA at 11:46, 30 October 2024

2024-10-30T11:46:59Z

← Older revision		Revision as of 11:46, 30 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7won]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WON FirstGlance]. <br>		<table><tr><td colspan='2'>[[7won]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WON FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.9Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7won FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7won OCA], [https://pdbe.org/7won PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7won RCSB], [https://www.ebi.ac.uk/pdbsum/7won PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7won ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7won FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7won OCA], [https://pdbe.org/7won PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7won RCSB], [https://www.ebi.ac.uk/pdbsum/7won PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7won ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]		[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]

			==See Also==
			*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[Spike protein 3D structures\|Spike protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:54, 8 September 2022

2022-09-08T05:54:22Z

← Older revision		Revision as of 05:54, 8 September 2022
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	====		==Cryo-EM structure of SARS-CoV-2 S2P trimer in complex with neutralizing antibody VacW-209 (local refinement)==
	<StructureSection load='7won' size='340' side='right'caption='[[7won]]' scene=''>		<StructureSection load='7won' size='340' side='right'caption='[[7won]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7won]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WON FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7won FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7won OCA], [https://pdbe.org/7won PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7won RCSB], [https://www.ebi.ac.uk/pdbsum/7won PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7won ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7won FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7won OCA], [https://pdbe.org/7won PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7won RCSB], [https://www.ebi.ac.uk/pdbsum/7won PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7won ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Z~~-disk~~]]		[[Category: Severe acute respiratory syndrome coronavirus 2]]
			[[Category: Ju B]]
			[[Category: Li S]]
			[[Category: Sun H]]
			[[Category: Xia N]]
			[[Category: Zhang Z]]
			[[Category: Zheng Q]]

OCA at 05:18, 13 July 2022

2022-07-13T05:18:34Z

← Older revision		Revision as of 05:18, 13 July 2022
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 7won ~~is ON HOLD until Paper Publication~~		====
			<StructureSection load='7won' size='340' side='right'caption='[[7won]]' scene=''>
	~~Authors~~: ~~Zheng, Q~~.~~, Sun, H~~.~~, Ju, B~~.~~, Zhang, Z~~.~~, Li, S~~.~~, Xia, N~~.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~: ~~Cryo-EM structure of SARS-CoV-2 S2P trimer in complex with neutralizing antibody VacW-209 (local refinement)~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7won FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7won OCA], [https://pdbe.org/7won PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7won RCSB], [https://www.ebi.ac.uk/pdbsum/7won PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7won ProSAT]</span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		</table>
	[~~[Category~~: Li, ~~S]]~~		__TOC__
	[~~[Category~~: ~~Zhang~~, ~~Z]]~~		</StructureSection>
	[~~[Category~~: Ju, ~~B]]~~		[[Category: Large Structures]]
	[[~~Category~~: ~~Zheng, Q]~~]		[[Category: Z-disk]]
	[[Category: ~~Sun, H~~]]
	[[Category: ~~Xia, N~~]]

OCA at 05:12, 2 March 2022

2022-03-02T05:12:03Z

← Older revision		Revision as of 05:12, 2 March 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7won is ON HOLD		The entry 7won is ON HOLD until Paper Publication

	Authors: Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N.		Authors: Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N.
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	[[Category: Li, S]]		[[Category: Li, S]]
	[[Category: Zhang, Z]]		[[Category: Zhang, Z]]
	~~[[Category: Xia, N]]~~
	[[Category: Ju, B]]		[[Category: Ju, B]]
	[[Category: Zheng, Q]]		[[Category: Zheng, Q]]
	[[Category: Sun, H]]		[[Category: Sun, H]]
			[[Category: Xia, N]]

OCA: Protected "7won" [edit=sysop:move=sysop]

2022-02-02T05:47:13Z

Protected "7won" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:47, 2 February 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7won is ON HOLD Authors: Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. Description: Cryo-EM structure of SARS-CoV-2 S2P trimer in complex ...

2022-02-02T05:47:12Z

New page: '''Unreleased structure''' The entry 7won is ON HOLD Authors: Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. Description: Cryo-EM structure of SARS-CoV-2 S2P trimer in complex ...

New page

'''Unreleased structure'''

The entry 7won is ON HOLD

Authors: Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N.

Description: Cryo-EM structure of SARS-CoV-2 S2P trimer in complex with neutralizing antibody VacW-209 (local refinement)
[[Category: Unreleased Structures]]
[[Category: Li, S]]
[[Category: Zhang, Z]]
[[Category: Xia, N]]
[[Category: Ju, B]]
[[Category: Zheng, Q]]
[[Category: Sun, H]]