7xml - Revision history

OCA at 07:27, 3 July 2024

2024-07-03T07:27:36Z

← Older revision		Revision as of 07:27, 3 July 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7xml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168] and [https://en.wikipedia.org/wiki/Bacillus_virus_SPO1 Bacillus virus SPO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[7xml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168] and [https://en.wikipedia.org/wiki/Bacillus_virus_SPO1 Bacillus virus SPO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xml OCA], [https://pdbe.org/7xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xml RCSB], [https://www.ebi.ac.uk/pdbsum/7xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xml OCA], [https://pdbe.org/7xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xml RCSB], [https://www.ebi.ac.uk/pdbsum/7xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xml ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ENO_BACSU ENO_BACSU]] Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.[HAMAP-Rule:MF_00318]		[https://www.uniprot.org/uniprot/ENO_BACSU ENO_BACSU] Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.[HAMAP-Rule:MF_00318]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7xml" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7xml" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Enolase 3D structures\|Enolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:19, 8 September 2022

2022-09-08T04:19:04Z

← Older revision		Revision as of 04:19, 8 September 2022
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	====		==Cryo-EM structure of PEIP-Bs_enolase complex==
	<StructureSection load='7xml' size='340' side='right'caption='[[7xml]]' scene=''>		<StructureSection load='7xml' size='340' side='right'caption='[[7xml]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[7xml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168] and [https://en.wikipedia.org/wiki/Bacillus_virus_SPO1 Bacillus virus SPO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XML FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xml OCA], [https://pdbe.org/7xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xml RCSB], [https://www.ebi.ac.uk/pdbsum/7xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xml ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xml OCA], [https://pdbe.org/7xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xml RCSB], [https://www.ebi.ac.uk/pdbsum/7xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xml ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/ENO_BACSU ENO_BACSU]] Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.[HAMAP-Rule:MF_00318]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Enolase is a highly conserved enzyme that presents in all organisms capable of glycolysis or fermentation. Its immediate product phosphoenolpyruvate is essential for other important processes like peptidoglycan synthesis and the phosphotransferase system in bacteria. Therefore, enolase inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP) of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth attenuation, thinner cell walls, and safranin color in Gram staining owing to impaired peptidoglycan synthesis. We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting the basic dimer unit. The structure reveals that PEIP does not compete for substrate binding but induces a cascade of conformational changes that limit accessibility to the enolase catalytic site. This phage-inspired disassembly of enolase represents an alternative strategy for the development of anti-microbial drugs.

			Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor.,Zhang K, Li S, Wang Y, Wang Z, Mulvenna N, Yang H, Zhang P, Chen H, Li Y, Wang H, Gao Y, Wigneshweraraj S, Matthews S, Zhang K, Liu B Cell Rep. 2022 Jul 5;40(1):111026. doi: 10.1016/j.celrep.2022.111026. PMID:35793626<ref>PMID:35793626</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 7xml" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus subtilis subsp. subtilis str. 168]]
			[[Category: Bacillus virus SPO1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Li S]]
			[[Category: Zhang K]]

OCA at 18:06, 27 July 2022

2022-07-27T18:06:44Z

← Older revision		Revision as of 18:06, 27 July 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 7xml is ~~ON HOLD until Paper Publication~~		====
			<StructureSection load='7xml' size='340' side='right'caption='[[7xml]]' scene=''>
	~~Authors:~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xml OCA], [https://pdbe.org/7xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xml RCSB], [https://www.ebi.ac.uk/pdbsum/7xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xml ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA at 03:54, 15 June 2022

2022-06-15T03:54:20Z

← Older revision		Revision as of 03:54, 15 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 7xml is ON HOLD		The entry 7xml is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xml" [edit=sysop:move=sysop]

2022-05-04T11:41:47Z

Protected "7xml" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:41, 4 May 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 7xml is ON HOLD Authors: Description: Category: Unreleased Structures

2022-05-04T11:41:46Z

New page: '''Unreleased structure''' The entry 7xml is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xml is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]