8a10 - Revision history

OCA at 06:24, 19 June 2024

2024-06-19T06:24:23Z

← Older revision		Revision as of 06:24, 19 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8a10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A10 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A10 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a10 OCA], [https://pdbe.org/8a10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a10 RCSB], [https://www.ebi.ac.uk/pdbsum/8a10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a10 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a10 OCA], [https://pdbe.org/8a10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a10 RCSB], [https://www.ebi.ac.uk/pdbsum/8a10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a10 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]		[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]

			==See Also==
			*[[Brachyury\|Brachyury]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:58, 8 September 2022

2022-09-08T05:58:32Z

← Older revision		Revision as of 05:58, 8 September 2022
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	==Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143==		==Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143==
	<StructureSection load='8a10' size='340' side='right'caption='[[8a10]]' scene=''>		<StructureSection load='8a10' size='340' side='right'caption='[[8a10]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A10 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A10 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a10 OCA], [https://pdbe.org/8a10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a10 RCSB], [https://www.ebi.ac.uk/pdbsum/8a10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a10 ProSAT]</span></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a10 OCA], [https://pdbe.org/8a10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a10 RCSB], [https://www.ebi.ac.uk/pdbsum/8a10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a10 ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
			== Function ==
			[[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Aitkenhead H]]		[[Category: Aitkenhead H]]

OCA at 05:19, 13 July 2022

2022-07-13T05:19:51Z

← Older revision		Revision as of 05:19, 13 July 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8a10 is ~~ON HOLD~~		==Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143==
			<StructureSection load='8a10' size='340' side='right'caption='[[8a10]]' scene=''>
	~~Authors~~: ~~Newman~~, J.A., ~~Gavard, A~~., ~~Aitkenhead, H~~.~~, Imprachim, N~~.~~, Sherestha, L~~., ~~Burgess-Brown, N~~.A.~~, von Delft, F~~., ~~Bountra, C~~.~~, Gileadi, O~~.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A10 FirstGlance]. <br>
	~~Description: Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a10 OCA], [https://pdbe.org/8a10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a10 RCSB], [https://www.ebi.ac.uk/pdbsum/8a10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a10 ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Burgess-Brown, N.A~~]]		__TOC__
	[[Category: ~~Von Delft, F~~]]		</StructureSection>
	[[Category: ~~Aitkenhead, H~~]]		[[Category: Large Structures]]
	[[Category: ~~Sherestha, L~~]]		[[Category: Aitkenhead H]]
	[[Category: Gileadi, O]]		[[Category: Bountra C]]
	[[Category: ~~Newman, J.A~~]]		[[Category: Burgess-Brown NA]]
	[[Category: ~~Imprachim, N~~]]		[[Category: Gavard A]]
	[[Category: ~~Gavard, A~~]]		[[Category: Gileadi O]]
	[[Category: ~~Bountra, C~~]]		[[Category: Imprachim N]]
			[[Category: Newman JA]]
			[[Category: Sherestha L]]
			[[Category: Von Delft F]]

OCA at 07:16, 22 June 2022

2022-06-22T07:16:01Z

← Older revision		Revision as of 07:16, 22 June 2022
Line 7:		Line 7:
	Description: Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143		Description: Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Burgess-Brown, N.A]]
			[[Category: Von Delft, F]]
			[[Category: Aitkenhead, H]]
	[[Category: Sherestha, L]]		[[Category: Sherestha, L]]
	[[Category: Gileadi, O]]		[[Category: Gileadi, O]]
	[[Category: Newman, J.A]]		[[Category: Newman, J.A]]
	~~[[Category: Burgess-Brown, N.A]]~~
	[[Category: Imprachim, N]]		[[Category: Imprachim, N]]
	[[Category: Gavard, A]]		[[Category: Gavard, A]]
	~~[[Category: Von Delft, F]]~~
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	~~[[Category: Aitkenhead, H]]~~

OCA: Protected "8a10" [edit=sysop:move=sysop]

2022-06-08T04:22:10Z

Protected "8a10" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:22, 8 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a10 is ON HOLD Authors: Newman, J.A., Gavard, A., Aitkenhead, H., Imprachim, N., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Bountra, C., Gi...

2022-06-08T04:22:09Z

New page: '''Unreleased structure''' The entry 8a10 is ON HOLD Authors: Newman, J.A., Gavard, A., Aitkenhead, H., Imprachim, N., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Bountra, C., Gi...

New page

'''Unreleased structure'''

The entry 8a10 is ON HOLD

Authors: Newman, J.A., Gavard, A., Aitkenhead, H., Imprachim, N., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Bountra, C., Gileadi, O.

Description: Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
[[Category: Unreleased Structures]]
[[Category: Sherestha, L]]
[[Category: Gileadi, O]]
[[Category: Newman, J.A]]
[[Category: Burgess-Brown, N.A]]
[[Category: Imprachim, N]]
[[Category: Gavard, A]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]
[[Category: Aitkenhead, H]]