8a34 - Revision history

OCA at 08:56, 4 March 2026

2026-03-04T08:56:02Z

← Older revision		Revision as of 08:56, 4 March 2026
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	<table><tr><td colspan='2'>[[8a34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A34 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KYI:5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione'>KYI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KYI:5-(2-phenylphenyl)-1~{H}-pyrimidine-2,4-dione'>KYI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a34 OCA], [https://pdbe.org/8a34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a34 RCSB], [https://www.ebi.ac.uk/pdbsum/8a34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a34 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a34 OCA], [https://pdbe.org/8a34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a34 RCSB], [https://www.ebi.ac.uk/pdbsum/8a34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a34 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:51, 27 September 2023

2023-09-27T06:51:20Z

← Older revision		Revision as of 06:51, 27 September 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8a34 is ~~ON HOLD until Paper Publication~~		==MTH1 in complex with TH013071==
			<StructureSection load='8a34' size='340' side='right'caption='[[8a34]], [[Resolution\|resolution]] 1.90Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8a34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A34 FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KYI:5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione'>KYI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a34 OCA], [https://pdbe.org/8a34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a34 RCSB], [https://www.ebi.ac.uk/pdbsum/8a34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a34 ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Liu H]]
			[[Category: Scaletti E]]
			[[Category: Stenmark P]]

OCA at 04:10, 20 July 2022

2022-07-20T04:10:23Z

← Older revision		Revision as of 04:10, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a34 is ON HOLD		The entry 8a34 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8a34" [edit=sysop:move=sysop]

2022-06-15T04:06:40Z

Protected "8a34" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:06, 15 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a34 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-15T04:06:39Z

New page: '''Unreleased structure''' The entry 8a34 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8a34 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]