8a3b - Revision history

OCA at 06:43, 24 July 2024

2024-07-24T06:43:43Z

← Older revision		Revision as of 06:43, 24 July 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8a3b]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A3B FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a3b]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A3B FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a3b OCA], [https://pdbe.org/8a3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a3b RCSB], [https://www.ebi.ac.uk/pdbsum/8a3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a3b ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a3b OCA], [https://pdbe.org/8a3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a3b RCSB], [https://www.ebi.ac.uk/pdbsum/8a3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a3b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PANX1_MOUSE PANX1_MOUSE] ~~Structural component~~ of ~~the gap junctions~~ and ~~the hemichannels. May play a role as a Ca~~(2+)-~~leak channel to regulate ER Ca~~(2+) ~~homeostasis~~ (~~By similarity~~)~~. Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation~~. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis~~. Plays a critical role in oogenesis~~.[UniProtKB:Q96RD7]		[https://www.uniprot.org/uniprot/PANX1_MOUSE PANX1_MOUSE] Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:30814251). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (PubMed:22311122). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity).[UniProtKB:Q96RD7]<ref>PMID:22311122</ref> <ref>PMID:30814251</ref> <ref>PMID:32238926</ref> During apoptosis and after cleavage by caspases of the C-terminal tail, acts as a plasma membrane channel which mediates the regulated release of find-me signals, such as nucleotides ATP and UTP, and selective plasme membrane permeability.<ref>PMID:32238926</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 8a3b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 8a3b" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Pannexin\|Pannexin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:45, 8 February 2023

2023-02-08T06:45:13Z

@@ Line 1: / Line 1: @@
-The entry 8a3b is ON HOLD  until Paper Publication
+==Cryo-EM structure of mouse Pannexin 1 purified in Salipro nanoparticles==
-Authors: Drulyte, I.
+Direct cell extraction of membrane proteins for structure-function analysis.,Drulyte I, Gutgsell AR, Lloris-Garcera P, Liss M, Geschwindner S, Radjainia M, Frauenfeld J, Loving R Sci Rep. 2023 Jan 25;13(1):1420. doi: 10.1038/s41598-023-28455-w. PMID:36697499<ref>PMID:36697499</ref>
-Description: Cryo-EM structure of mouse Pannexin 1 purified in Salipro nanoparticles
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Drulyte, I]]
+<div class="pdbe-citations 8a3b" style="background-color:#fffaf0;"></div>

OCA at 04:06, 13 July 2022

2022-07-13T04:06:06Z

← Older revision		Revision as of 04:06, 13 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a3b is ON HOLD		The entry 8a3b is ON HOLD until Paper Publication

	Authors: Drulyte, I.		Authors: Drulyte, I.

OCA: Protected "8a3b" [edit=sysop:move=sysop]

2022-06-15T04:06:55Z

Protected "8a3b" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:06, 15 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a3b is ON HOLD Authors: Drulyte, I. Description: Cryo-EM structure of mouse Pannexin 1 purified in Salipro nanoparticles [[Category: Unreleased St...

2022-06-15T04:06:54Z

New page: '''Unreleased structure''' The entry 8a3b is ON HOLD Authors: Drulyte, I. Description: Cryo-EM structure of mouse Pannexin 1 purified in Salipro nanoparticles [[Category: Unreleased St...

New page

'''Unreleased structure'''

The entry 8a3b is ON HOLD

Authors: Drulyte, I.

Description: Cryo-EM structure of mouse Pannexin 1 purified in Salipro nanoparticles
[[Category: Unreleased Structures]]
[[Category: Drulyte, I]]